{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:44:42Z","timestamp":1747223082562,"version":"3.40.5"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"05","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Studies in different populations have shown that single-nucleotide polymorphisms (SNPs) of tumor necrosis factor-alpha (TNF\u03b1) and TNF receptors 1 and 2 (TNFR1 and TNFR2) may be involved in the pathogenesis of lepromatous leprosy (LL). To further explore the results in a Mexican population, we compared the frequencies of the polymorphisms in - 308 G&gt;A TNFA (rs1800629), - 383 A&gt;C TNFRS1A (rs2234649), and + 196 T &gt;G TNFSR1B (rs1061622) genes in LL patients (n = 133) and healthy subjects (n = 198).\nMethodology: The genotyping was performed with the polymerase chain reaction-based restriction fragment length polymorphism (PCR\u2013RFLP) technique. Statistical analysis was performed using the \u03c72 test, within the 95% confidence interval. Odds ratios (OR) were calculated and Hardy-Weinberg equilibrium was verified for all control subjects and patients.\nResults: We found an association between the TNFSR1 -383 A&gt;C genotype and the risk of lepromatous leprosy when leprosy patients were compared to controls (OR = 1.71, CI: 1.08-2.69, p = 0.02). Furthermore, it was also associated with the risk of LL in a dominant model (AC + CC vs AA, OR: 1.65, 95% CI: 1.05-2.057, p = 0.02). Similar genotype and allele frequencies for the SNPs TNFA - 308 G&gt;A and TNFSR2 + 196 T&gt;G were observed between leprosy patients and healthy subjects.\nConclusions: The TNFSR1 -383 A&gt;C could be a potential marker for the identification of high-risk populations. However, additional studies, using larger samples of different ethnic populations, are required.<\/jats:p>","DOI":"10.3855\/jidc.17658","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T17:57:21Z","timestamp":1718128641000},"page":"770-778","source":"Crossref","is-referenced-by-count":0,"title":["Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients"],"prefix":"10.3855","volume":"18","author":[{"given":"Margarita","family":"Montoya-Buelna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-1712","authenticated-orcid":false,"given":"Anabell","family":"Alvarado-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose F","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-4108","authenticated-orcid":false,"given":"Rocio I","family":"Lopez-Roa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-8810","authenticated-orcid":false,"given":"Celia","family":"Guerrero-Velazquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Fafutis-Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2024,5,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/38865403\/3352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/38865403\/3352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T23:23:48Z","timestamp":1721345028000},"score":1,"resource":{"primary":{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/view\/38865403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2024,5,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.17658","relation":{},"ISSN":["1972-2680"],"issn-type":[{"type":"electronic","value":"1972-2680"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}