{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:37:41Z","timestamp":1788824261001,"version":"build-2803163510"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"10","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The aim of this study was to evaluate the diagnostic and prognostic values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), monocyte-to-lymphocyte ratio (MLR), neutrophils-to-lymphocytes and platelets ratio (N\/LPR), mean platelet volume-to-platelet count ratio (MPV\/PC), red blood cell distribution width-to-platelet count ratio (RDW\/PC), and platelet volume distribution width-to-platelet count ratio (PDW\/PC) in patients with sepsis.\nMethodology: A total of 203 patients with sepsis admitted to an emergent intensive care unit (EICU) were enrolled in this retrospective study. Basic data, inflammatory factors, NLR, PLR, PNR, MLR, N\/LPR, MPV\/PC, RDW\/PC, PDW\/PC were compared between survival and non-survival groups. Receiver operating characteristic (ROC) curve was used to assess the diagnostic values. The univariate and multivariate regression analyses were used for constructing a prognostic model for sepsis.\nResults: There were significant differences in acute physiology and chronic health evaluation (APACHEII) score, mechanical ventilation, use of vasopressors, acute kidney injury (AKI), continuous renal replacement therapy (CRRT), long-term antiplatelet drug use, lymphocyte, monocyte, hemoglobin, procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP)*PCT, and N\/LPR. APACHE II had the highest diagnostic value [Area Under Curve (AUC) = 0.999], followed by CRP*PCT (AUC = 0.718). The prognoses were different between patients stratified according to CRP, IL-6, lactic acid (Lac), PNR, PLR, PDW\/PC, and APACHEII. Lac, CRP*PCT, PDW\/PC, MPV\/PC and APACHE II were independent prognostic factors of sepsis.\nConclusions: Both N\/LPR and CRP*PCT had high values to predict mortality in sepsis patients. CRP*PCT, PDW\/PC and MPV\/PC were independent factors to predict the prognosis of sepsis.<\/jats:p>","DOI":"10.3855\/jidc.17907","type":"journal-article","created":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:07:38Z","timestamp":1699787258000},"page":"1362-1372","source":"Crossref","is-referenced-by-count":24,"title":["Diagnostic and prognostic values of immunocyte ratios in patients with sepsis in the intensive care unit"],"prefix":"10.3855","volume":"17","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2023,10,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/17907\/3183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/17907\/3183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:07:38Z","timestamp":1699787258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/17907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.17907","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]}}}