{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:12:24Z","timestamp":1785247944267,"version":"3.55.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"03","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: This study evaluated the prognostic value of serum cytokines tumor necrosis factor-alpha (TNF-\u03b1), procalcitonin (PCT), interleukin-8 (IL-8), and heparin binding protein (HBP); combined with acute physiology and chronic health evaluation II (APACHE II) score in sepsis patients.\nMethodology: Patients were divided into sepsis and septic shock groups based on sepsis-3 criteria, with non-sepsis individuals as controls. Serum TNF-\u03b1, PCT, IL-8, and HBP levels; and APACHE II scores were recorded upon intensive care unit (ICU) admission. The diagnostic value was evaluated using receiver operating characteristic (ROC) curves and areas under the curves (AUCs).\nResults: Correlation analysis revealed that serum TNF-\u03b1 (r = 0.701), PCT (r = 0.623), IL-8 (r = 0.617), and HBP (r = 0.721) were positively correlated with the APACHE II score (p &lt; 0.05). Serum TNF-\u03b1, PCT, IL-8, HBP levels, and APACHE II scores were significantly higher in non-survivors than survivors (p &lt; 0.05). The AUC for combined indicators in predicting mortality was 0.913 (confidence interval, CI: 0.861\u20130.912), significantly higher than individual indicators. HBP showed AUC of 0.798 (CI: 0.707\u20130.879) and APACHE II 0.769 (CI: 0.782\u20130.892). The combined prediction demonstrated 96.21% sensitivity and 79.34% specificity.\nConclusions: Serum TNF-\u03b1, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes.<\/jats:p>","DOI":"10.3855\/jidc.20383","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:29:42Z","timestamp":1743427782000},"page":"439-445","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic value of TNF-\u03b1, PCT, IL-8, and HBP, combined with APACHE II score in patients with sepsis"],"prefix":"10.3855","volume":"19","author":[{"given":"Shuping","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2025,3,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20383\/3615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20383\/3615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:29:43Z","timestamp":1743427783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,3,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20383","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]}}}