{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:35:44Z","timestamp":1765200944230,"version":"3.46.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"11","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The effectiveness of remdesivir (RDV) and interferon beta-1a (IFN\u03b2-1a) was assessed and compared in patients hospitalized with coronavirus disease of 2019 (COVID-19).\nMethodology: A total of 162 hospitalized COVID-19 patients were divided into two groups: the RDV group and the IFN\u03b2-1a group. Through laboratory tests and a physical examination, the patient's clinical condition was evaluated.\nResults: RDV and IFN\u03b2-1a treatments significantly decreased fever, cough, shortness of breath, and weakness in COVID-19 patients (All p &lt; 0.001). RDV treatment significantly decreased shortness of breath, erythrocyte sedimentation rate (ESR), and creatinine, relative to IFN\u03b2-1a treatment (p &lt; 0.03, p = 0.001, and p &lt; 0.004, respectively). RDV treatment significantly decreased Lactate Dehydrogenase (LDH) in COVID-19 patients (p = 0.006). The mean time of hospitalization was 8.9 days in the RDV group and 8.2 days in the IFN\u03b2-1a group. There was no statistical difference between the two groups. The IFN\u03b2-1a group had a considerably lower rate of intensive care unit (ICU) admission than the RDV group (p = 0.006).\nConclusions: No difference in clinical outcomes was found between RDV and IFN\u03b2-1a treatments. RDV was more effective than IFN\u03b2-1a in moderating the inflammatory response in COVID-19 patients by reducing LDH and ESR. The IFN\u03b2-1a group had a considerably lower rate of ICU admission than the RDV group.<\/jats:p>","DOI":"10.3855\/jidc.20584","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:33:20Z","timestamp":1765200800000},"page":"1606-1614","source":"Crossref","is-referenced-by-count":0,"title":["Comparing the clinical outcomes of Remdesivir and Interferon beta-1a in hospitalized COVID-19 patients: A cross-sectional retrospective single-center study"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-1883","authenticated-orcid":false,"given":"Mehrdad","family":"Asgari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Kousha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8301-8710","authenticated-orcid":false,"given":"Mohammad Ebrahim","family":"Ghaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tofigh","family":"Yaghubi Kalurazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Zaminy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2025,11,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20584\/3765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20584\/3765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:33:20Z","timestamp":1765200800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20584","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]}}}