{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:13:39Z","timestamp":1751516019150,"version":"3.41.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"06","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The aim of this study was to explore the impact of empiric antibiotic de-escalation for suspected early onset neonatal sepsis (EONS) on clinical and economic outcomes. This was a multicenter prospective cohort study. Newborns were recruited from 3 neonatal intensive care units (NICUs) in Klang Valley, Malaysia.\nMethodology: All newborns in the NICU, and prescribed with empiric antibiotics within 72 hours for EONS over 4 months were included. Data on newborns\u2019 characteristics, clinical outcomes, cost-effectiveness in 7 days, and mortality in 28 days were recorded. Antibiotic usage was divided into de-escalation and non-de-escalation groups, with 1:1 data matching for gestational age (weeks) and birth weight (\u00b1 0.1 kg). Time to treatment success, 28-days all-cause mortality, and cost-effectiveness were analyzed.\nResults: A total of 687 newborns were included. Data matching was conducted for grouping into de-escalation and non-de-escalation groups (n = 262 per group) for comparative analysis. There was no significant difference in the treatment failure rate (p = 0.742) and all-cause mortality in 28-days of life (p = 0.052) between the groups. However, a significant difference in terms of time to treatment success (median 3 days in the de-escalation group vs. 5 days in the non-de-escalation group; p &lt; 0.001)) was observed. Cost-effectiveness analysis showed cost-saving of USD 47.80 per newborn per day for the de-escalation group.\nConclusions: Early empiric antibiotic de-escalation should be considered in all newborns with a low risk of EONS. This practice did not increase the treatment failure rate and provided a beneficial outcome.<\/jats:p>","DOI":"10.3855\/jidc.20654","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:11:17Z","timestamp":1751476277000},"page":"896-903","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the potential impact of empiric antibiotic de-escalation for suspected early onset neonatal sepsis"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-6985","authenticated-orcid":false,"given":"Nazedah","family":"Ain Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd","family":"Makmor Bakry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shareena","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurul Ain","family":"Mohd Tahir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noraida","family":"Mohamed Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2025,6,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20654\/3675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20654\/3675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:11:17Z","timestamp":1751476277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20654","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}