{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:13:38Z","timestamp":1751516018434,"version":"3.41.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"06","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Prediction of HBeAg loss is crucial for understanding the prognosis of chronic hepatitis B (CHB) and determining when to discontinue treatment. We aimed to identify factors predicting HBeAg clearance in patients undergoing antiviral treatment for HBeAg-positive CHB\nMethodology: This retrospective study included patients who started antiviral treatment for HBeAg-positive CHB from January 1, 2008, to December 31, 2022, with at least one year of follow-up. We evaluated age, platelet count, treatment duration, ALT \u00d7 Upper limit of normal (ULN), AST \u00d7 ULN, AST\/ALT ratio, Albumin-Bilirubin grade (ALBI), Platelet-Albumin-Bilirubin grade (PALBI), AST-Platelet ratio index (APRI), and Fibrosis-4 (FIB-4) parameters. ROC analysis was used to assess these parameter's ability to predict HBeAg loss.\nResults: Ninety-four patients were included, 43 (45.7%) of whom were female. HBeAg clearance occurred in 32 (34%) patients. Treatment duration was significantly longer in patients with HBeAg clearance (p = 0.003). Patients with HBeAg clearance had significantly higher median age, fibrosis score (FS), APRI, and FIB-4 values (p = 0.028, p = 0.024, p = 0.008, and p = 0.003, respectively) and lower mean platelet count (p = 0.010) at treatment initiation. ROC analysis identified age, FS, APRI, FIB-4, and platelet count as significant predictors, with APRI having the highest area under the curve (AUC = 0.771, p = 0.007, sensitivity 65%, specificity 66.7% for the cut-off value of 0.71).\nConclusions: This study highlights the potential of FIB-4, platelet count, and particularly APRI in predicting HBeAg clearance. These findings can aid clinicians in optimizing treatment strategies and improving patient outcomes.<\/jats:p>","DOI":"10.3855\/jidc.20784","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:11:10Z","timestamp":1751476270000},"page":"941-947","source":"Crossref","is-referenced-by-count":0,"title":["HBeAg clearance in chronic Hepatitis B: is it predictable?"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-8295","authenticated-orcid":false,"given":"Tuba","family":"\u0130lgar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-8594","authenticated-orcid":false,"given":"Aybeg\u00fcm","family":"\u00d6z\u015fahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudem","family":"Mahmuto\u011flu \u00c7olak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lknur Esen","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"Kostako\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Ert\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2025,6,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20784\/3680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20784\/3680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:11:10Z","timestamp":1751476270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20784","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}