{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:41:00Z","timestamp":1792554060760,"version":"4.5.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"10","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Majority of patients admitted to intensive care units (ICUs) succumb to sepsis and its complications. However, currently available predictors fail to reliably gauge the severity of organ damage. There is a pressing need to identify biomarkers that can accurately forecast outcomes. Interleukin-6 (IL-6) has emerged as a potential biomarker, with some studies suggesting its utility as an early predictor of multi-organ failure in sepsis. This study evaluated the role of IL-6 in predicting mortality in an Indian ICU setting.\nMethodology: This prospective observational study included adult patients diagnosed with sepsis and a quick SOFA score \u2265 2. IL-6 levels, SOFA scores, and other clinical parameters were measured within 24 hours of admission. Univariate and multivariate analyses identified factors associated with mortality.\nResults: The overall ICU mortality rate was 39%. Multivariate analyses indicated that IL-6 levels, total SOFA scores, and number of antibiotics used were independently associated with mortality. The IL-6 levels showed strong positive correlations with the total SOFA score (r = 0.77, p &lt; 0.001) and individual organ dysfunction scores; particularly in cardiovascular (r = 0.61, p &lt; 0.001), renal (r = 0.64, p &lt; 0.001), and central nervous system (r = 0.6, p &lt; 0.001).\nConclusions: IL-6 levels, in combination with SOFA scores, provide a robust predictor of mortality in sepsis patients. The strong correlation between IL-6 levels and organ dysfunction scores suggests its potential as a biomarker for sepsis severity and progression.<\/jats:p>","DOI":"10.3855\/jidc.20800","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:57:58Z","timestamp":1762279078000},"page":"1470-1478","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin-6 as a biomarker of sepsis and its clinical utility in predicting mortality: a prospective observational study"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-4334","authenticated-orcid":false,"given":"Syed S","family":"Ameen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-1427","authenticated-orcid":false,"given":"Shreya","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0486-9331","authenticated-orcid":false,"given":"Amrita","family":"Parida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-591X","authenticated-orcid":false,"given":"Ramya","family":"Kateel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"V","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2025,10,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20800\/3747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20800\/3747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:57:58Z","timestamp":1762279078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20800","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}