{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:32:00Z","timestamp":1770618720122,"version":"3.49.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"03","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The eradication rates of Helicobacter pylori (H. pylori) in Vietnam, with both triple therapy and non-bismuth quadruple therapy, have significantly declined due to increasing antibiotic resistance. This prospective study aimed to evaluate the eradication efficacy of high-dose dual therapy (HDDT) with esomeprazole and amoxicillin in a region with high resistance rates to clarithromycin, metronidazole, and levofloxacin.\nMethodology: A total of 82 patients with active H. pylori infection, confirmed by either a rapid urease test or a \u00b9\u00b3C urea breath test, were enrolled at our hospital. All participants received esomeprazole (40 mg) and amoxicillin (1,000 mg), 3 times daily for 14 days. Treatment success was assessed using a \u00b9\u00b3C urea breath test 4\u20136 weeks post-treatment. Safety was evaluated based on reported adverse effects.\nResults: Gastritis, gastric ulcer, and duodenal ulcer were present in 80.5%, 10.4%, and 9.1% of cases, respectively. The eradication rates according to intention-to-treat (ITT) and per-protocol (PP) analyses were 76.8% (63\/82) and 81.8% (63\/77), respectively. In the PP analysis, the eradication rate was 86.0% (49\/57) in first-line treatment, and 70.0% (14\/20) in patients with prior H. pylori treatment failure. Mild side effects, including nausea, abdominal discomfort, pruritus, diarrhea, and fatigue, were reported in 22.1% (17\/77) of patients.\nConclusions: This study demonstrates that a 14-day HDDT regimen provides relatively high efficacy and a favorable safety profile for first-line H. pylori eradication. Given the widespread resistance to clarithromycin, levofloxacin, and metronidazole in Vietnam; HDDT may serve as an alternative first-line therapy for H. pylori eradication in this region.<\/jats:p>","DOI":"10.3855\/jidc.20820","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:29:31Z","timestamp":1743427771000},"page":"404-408","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of 14-day high-dose dual therapy for Helicobacter pylori infection in Vietnam"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7668-8058","authenticated-orcid":false,"given":"Nam T","family":"Phan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long H","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2025,3,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20820\/3610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/20820\/3610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:29:32Z","timestamp":1743427772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/20820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,3,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.20820","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]}}}