{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:51:53Z","timestamp":1783644713062,"version":"3.55.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"02","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created significant challenges in predicting severe disease outcomes. This study evaluates the combined prognostic performance of serum ferritin, national early warning score (NEWS), and computed tomography severity score (CT-SS) in predicting intensive care unit (ICU) admission and 30-day mortality.\nMethodology: This retrospective study included 693 COVID-19 patients with confirmed RT-PCR results and complete medical records. Demographic, clinical, and laboratory data, including ferritin levels, NEWS, and CT-SS, were analyzed. Statistical analyses were conducted to evaluate their individual and combined predictive capabilities.\nResults: Elevated ferritin levels, higher NEWS, and greater CT-SS were significantly associated with increased ICU admission and mortality risks. Receiver operating characteristic (ROC) analysis revealed excellent predictive accuracy for mortality: ferritin (area under the receiver operating characteristic curve [AUROC]: 0.916), NEWS (AUROC: 0.927), and CT-SS (AUROC: 0.881). Integrating ferritin into NEWS and CT-SS models enhanced predictive precision, with combined scoring systems yielding the highest odds ratios for adverse outcomes. Patients with a NEWS \u2265 5 and ferritin level \u2265 275.8 had a 151-fold increased risk of mortality, while those with a CT-SS \u2265 9 and ferritin level \u2265 275.8 had a 72-fold increased risk.\nConclusions: Combining ferritin with NEWS and CT-SS improves the prognostic accuracy for predicting severe outcomes in COVID-19 patients. This study emphasizes the value of integrating laboratory markers with established scoring systems to optimize clinical decision-making. The findings can guide early interventions, reduce mortality, and improve resource utilization during pandemics.<\/jats:p>","DOI":"10.3855\/jidc.21452","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:26:20Z","timestamp":1772821580000},"page":"167-174","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic performance of ferritin in combination with CT-SS and NEWS, to predict ICU admission and mortality in COVID-19"],"prefix":"10.3855","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-6084","authenticated-orcid":false,"given":"Murat","family":"Da\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-6090","authenticated-orcid":false,"given":"Fatma","family":"Beyaz\u0131t","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Bardakc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"\u00dcnal \u00c7etin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-0301","authenticated-orcid":false,"given":"G\u00f6khan","family":"Akdur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-5649","authenticated-orcid":false,"given":"Canan","family":"Akman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okhan","family":"Akdur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-2714","authenticated-orcid":false,"given":"Yavuz","family":"Beyaz\u0131t","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2026,2,28]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21452\/3820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21452\/3820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:26:20Z","timestamp":1772821580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,2,28]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21452","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}