{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:59:10Z","timestamp":1791568750011,"version":"4.3.4"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"09","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The problem of carbapenem resistance in Enterobacteriaceae is becoming increasingly serious, and Carbapenem-Resistant Enterobacteriaceae (CRE) has become a major problem in clinical infection, especially in intensive care units (ICU). The purpose of the study is to explore the impact of the occurrence of COVID-19 on the bloodstream infection of CRE (CRE-BSI) and carbapenem resistance.\nMethodology: In this study, adult patients with CRE-BSI from January 2019 to January 2023 were collected to perform a single-center cross-sectional study, who were divided into pre-COVID-19, COVID-19 until \\\"New Ten\\\" (only accept non-COVID-19 patients), and post-\\\"New Ten\\\" group (accept COVID-19 and non-COVID-19 patients), according to the epidemic prevention and control policy.\nResults: Among 184 CRE-BSI cases confirmed during pre-COVID-19, COVID-19 until \\\"New Ten\\\" and post-\\\"New Ten\\\" periods, the CRE-BSI rates were 7.81, 8.13, and 9.63 cases per 100,000 hospitalization days. Correspondingly, the carbapenem resistance rates in Enterobacteriaceae were 18.6%,16.4%, and 19.0%, respectively, although no significant statistical differences were noted between the examined periods. The intensity of antimicrobial use increased significantly (p &lt; 0.001) after the outbreak of the epidemic, and even increased to 1.5 times after the implementation of the \\\"New Ten\\\" compared to the pre-COVID-19 period. Notably, the utilization of third- and fourth-generation cephalosporins experienced a significant increase in CRE-BSI patients during the COVID-19 epidemic (p = 0.013).\nConclusions: During the epidemic, an increased broad-spectrum antimicrobial use happened in CRE-BSI patients.<\/jats:p>","DOI":"10.3855\/jidc.21495","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:47:26Z","timestamp":1791568046000},"page":"1290-1297","source":"Crossref","is-referenced-by-count":0,"title":["Impact of COVID-19 Pandemic on carbapenem-resistant Enterobacteriaceae bloodstream infection: a single-center study in China"],"prefix":"10.3855","volume":"20","author":[{"given":"Lian","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2026,9,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21495\/3958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21495\/3958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:47:26Z","timestamp":1791568046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21495","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}