{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:06:43Z","timestamp":1780913203949,"version":"3.54.1"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"05","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The Streptococcus anginosus group (SAG) is emerging as a significant cause of invasive infections, yet data from Vietnam remain scarce. This study characterized the clinical features and outcomes of SAG infections in Ho Chi Minh City.\nMethodology: We retrospectively reviewed patients with culture-confirmed SAG infections at the Hospital for Tropical Diseases (January 2017\u2013August 2023). Demographics, clinical, and microbiological data were analyzed.\nResults: A total of 82 patients (mean age 50.6\u202f\u00b1\u202f16.8 years; 64.6% male) with culture-confirmed SAG infections were included. Comorbidities were present in 56.1% of patients, with diabetes mellitus being the most common (23.2%). S. anginosus was the most frequently isolated species (43.9%), followed by S. constellatus (34.1%) and S. intermedius (22.0%). Bacteremia (35.4%) and intra-abdominal infections (31.7%, mainly hepatic abscesses) were the predominant clinical presentations. Polymicrobial infections occurred in 14.6% of cases, primarily among patients with bacteremia and skin or soft tissue infections. All isolates remained susceptible to ceftriaxone and vancomycin, and 94.3% to ampicillin, but susceptibilities were lower to penicillin (84.3%), erythromycin (65.7%), clindamycin (54.3%), and tetracycline (54.3%). Despite a 92.7% cure rate, 19.5% required drainage procedures, and the 28-day mortality rate was 6.1%.\nConclusions: In this cohort, SAG infection most often present as occult bacteremia or hepatobiliary abscess, frequently in patients with comorbidities, but not restricted to immunocompromised hosts. Empirical \u03b2-lactam therapy (ampicillin or ceftriaxone) remains appropriate, although rising penicillin and macrolide resistance and the 15% polymicrobial rate, may warrant broader initial coverage when deep soft-tissue foci are suspected.<\/jats:p>","DOI":"10.3855\/jidc.21557","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:23:18Z","timestamp":1780910598000},"page":"678-686","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and microbiological features of Streptococcus anginosus group infections: a 7-year retrospective study in Vietnam"],"prefix":"10.3855","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7000-5338","authenticated-orcid":false,"given":"Kim-Thu","family":"Le-Thai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0712-3524","authenticated-orcid":false,"given":"Buu Chau","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang-Anh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-3767","authenticated-orcid":false,"given":"Quoc-Khanh","family":"Tran-Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-2199","authenticated-orcid":false,"given":"Quang Minh","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2026,5,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21557\/3884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21557\/3884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:23:18Z","timestamp":1780910598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,5,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21557","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]}}}