{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:14:23Z","timestamp":1776194063415,"version":"3.50.1"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"03","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: This study aimed to investigate the distribution and drug resistance of clinically isolated Non-tuberculous Mycobacteria (NTM) strains in Lishui City, and to provide a basis for the development of NTM disease prevention and control strategies in the region.\nMethodology: This retrospective cross-sectional study was performed using NTM-positive clinical specimens collected from patients at a sentinel tuberculosis hospital in Lishui City, Zhejiang Province, China, between January 2023 and December 2024. The isolated NTM strains were identified using a gene chip\u2013based method. Antimicrobial susceptibility testing was conducted using the microbroth dilution method. Statistical analyses were applied to evaluate the isolation rate, species distribution, and drug-resistance patterns of the strains.\nResults: The isolation rate of NTM among clinical patients at the sentinel hospital was 18.09% (157\/868); The rate was significantly higher in women (26.97%, 72\/267) than in men (14.14%, 85\/601) (\u03c72 trend = 20.518, p &lt; 0.001); Nine common NTM species were identified, with Mycobacterium intracellulare being the most prevalent (68.79%, 108\/157), followed by Mycobacterium avium (11.46%, 18\/157) and Mycobacterium chelonae\/abscessus (8.28%, 13\/157). Antimicrobial susceptibility testing revealed high resistance rates to several drugs, including imipenem (94.27%, 148\/157), doxycycline (94.27%, 148\/157), rifampicin (91.72%, 144\/157), amoxicillin\/clavulanic acid (91.08%, 143\/157), meropenem (89.81%, 141\/157), cefoxitin (87.90%, 138\/157), minocycline (85.99%, 135\/157), and ciprofloxacin (85.99%, 135\/157). Species-specific differences in resistance patterns were observed.\nConclusions: The distribution of clinically isolated NTM strains in Lishui City was dominated by Mycobacterium intracellular, Mycobacterium avium, and Mycobacterium chelonae\/abscessus. These isolates demonstrated high levels of resistance to commonly used antimicrobial agents, highlighting the need for improved treatment and control strategies.<\/jats:p>","DOI":"10.3855\/jidc.21596","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:24:29Z","timestamp":1776191069000},"page":"435-444","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of non-tuberculous Mycobacteria strains and analysis of drug resistance in Lishui City, China"],"prefix":"10.3855","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2638-3551","authenticated-orcid":false,"given":"Henan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongda","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congjuan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2026,3,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21596\/3853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21596\/3853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:24:29Z","timestamp":1776191069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21596","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}