{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:35:38Z","timestamp":1765200938931,"version":"3.46.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"11","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Dengue remains a public health concern in Paraguay. Paraguay\u00b4s 2023\u20132024 epidemic was examined, emphasizing on the Itapua department in the southern region bordering Argentina.\nMethodology: This retrospective, cross-sectional observational study analyzed confirmed dengue cases from 17 September 2023, to 4 May 2024. Demographic and clinical data of the participants were gathered from Paraguay\u2019s national surveillance system.\nResults: Among the 307,058 suspected dengue cases reported, 77,675 were confirmed through laboratory testing. The Itapua department contributed 8,310 (2.7%) and 1,910 (2.5%) of the suspected and confirmed cases; pediatric cases comprised 33% nationwide and 35% in Itapua. Intensive care needs were higher in Itapua (n = 18, 11.2%) than in other Paraguayan regions (n = 152, 2.0%). Mortality rates were also elevated in Itapua (n = 11, 0.6%) compared to the national average (n = 95, 0.13%). DENV-1 and DENV-2 were responsible for this epidemic. Encarnacion, the capital of Itapua State and a neighboring city to Posadas, Argentina, was the most severely affected (1,262 reported cases).\nConclusions: The elevated rates of pediatric cases, intensive care admissions, and mortality in Itapua highlight the need for multicomponent health strategies, including enhanced vector control through community-led Aedes aegypti elimination programs and insecticide residual spraying in high-incidence zones, vaccination campaigns targeting high-risk pediatric populations with World Health Organization (WHO)-approved dengue vaccines (e.g., TAK-003), and cross-border collaboration with Argentina (e.g., Posadas-Encarnacion) to synchronize outbreak surveillance, share real-time epidemiological data, and coordinate vaccine deployment in binational hotspots.<\/jats:p>","DOI":"10.3855\/jidc.21624","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:33:04Z","timestamp":1765200784000},"page":"1694-1704","source":"Crossref","is-referenced-by-count":0,"title":["Dengue on the rise in Encarnaci\u00f3n, Paraguay (2023\u20132024): an emerging threat to regional transmission dynamics"],"prefix":"10.3855","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-358X","authenticated-orcid":false,"given":"Diana P","family":"Dressler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica M","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"G\u00f3mez de la Fuente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar A","family":"Cantero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania M","family":"Alfonzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-0776","authenticated-orcid":false,"given":"Victor H","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2025,11,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21624\/3776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21624\/3776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:33:04Z","timestamp":1765200784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21624","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]}}}