{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:32:45Z","timestamp":1770733965240,"version":"3.49.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"01","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: This study investigated the epidemiological characteristics, subtype distribution, and clinical correlations of cervical human papillomavirus (HPV) infection in Jingmen, China.\nMethodology: A retrospective study of 5,155 women screened at Jingmen Central Hospital (2022\u20132024). The participants were categorized into 6 age groups: \u2264 20 years (n = 54), 21-30 years (n = 791), 31-40 years (n = 1,757), 41-50 years (n = 1,371), 51-60 years (n = 968), and \u2265 61 years (n = 214). HPV genotyping and histopathology were used to assess infection patterns and lesion correlations.\nResults The infection rates of high-risk HPV (HR-HPV), low-risk HPV (LR-HPV), and mixed infections were 18.10% (933\/5,155), 3.38% (174\/5,155), and 3.38% (174\/5,155), respectively. HR-HPV infections exhibited a bimodal age distribution, with peak prevalence in women aged \u2264 20 years (33.33%) and \u2265 61 years (39.25%). This age-related difference was statistically significant (\u03c7\u00b2 = 81.430, p &lt; 0.001). The dominant subtypes were HPV52 (23.5%), HPV16 (13.9%), and HPV58 (13.3%). Notably, HPV16 was significantly more prevalent in high-grade squamous intraepithelial lesions (HSIL; 44.3%) and cervical cancer (CC; 55.5%), compared with low-grade lesions (p &lt; 0.01).\nConclusions: This study identified both adolescent\/young women (\u2264 20 years) and older women (\u2265 61 years) as high-risk populations for HR-HPV infection. Notably, HPV16 (55.5%) exhibited significantly higher detection rates in cervical cancer cases, emphasizing the importance of prioritizing this subtype in region-specific vaccine-based prevention strategies. These findings underscore the need for tailored clinical management approaches based on viral subtype distribution and lesion severity.<\/jats:p>","DOI":"10.3855\/jidc.21716","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:07:38Z","timestamp":1770660458000},"page":"129-133","source":"Crossref","is-referenced-by-count":0,"title":["Cervical HPV in central China: regional prevalence, subtypes and pathology"],"prefix":"10.3855","volume":"20","author":[{"given":"Jin","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3615-1174","authenticated-orcid":false,"given":"Hongliu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jilan","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuolin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7575-6131","authenticated-orcid":false,"given":"Xuan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2026,1,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21716\/3814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21716\/3814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:07:38Z","timestamp":1770660458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21716","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}