{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:14:22Z","timestamp":1776194062498,"version":"3.50.1"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"03","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Recent research indicates that individuals with inflammatory bowel disease (IBD) exhibit distinct intestinal fungal communities compared with healthy individuals. This study examined the relationship among anti-Saccharomyces cerevisiae antibodies (ASCA), perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), and Candida spp. colonization to assess their utility in diagnosing IBD, differentiating subtypes, and predicting disease localization.\nMethodology: Serum samples from 240 patients with IBD and 61 healthy controls were tested for ASCA and p-ANCA using indirect immunofluorescence assay (IIFA). Fecal samples were cultured to identify Candida species.\nResults: ASCA positivity was significantly higher in Crohn\u2019s disease (CD) (61.7%), whereas p-ANCA positivity was more frequent in ulcerative colitis (UC) (51.6%) (p = 0.005 and p = 0.002, respectively). Fluorescence intensity showed stronger ASCA reactivity in CD and higher p-ANCA intensity in UC. Candida colonization (\u2265 5 CFU) was detected in 64.2% of IBD patients, with Candida albicans the most common species. Saccharomyces cerevisiae was detected exclusively in IBD patients (3.7%, p = 0.038). Higher colonization rates were observed in UC with pancolitis (78.9%) and in CD with colonic involvement (80%). ASCA intensity inversely correlated with Candida load in CD (p = 0.021), whereas p-ANCA intensity positively correlated with Candida load in UC (p = 0.038). No significant differences in Candida species diversity were observed between subtypes.\nConclusions: These findings support the diagnostic value of ASCA and p-ANCA in distinguishing IBD subtypes and highlight their association with Candida colonization. Further studies are warranted to elucidate fungal antigen\u2013antibody interactions and to refine subtype-specific diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.3855\/jidc.21755","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:24:28Z","timestamp":1776191068000},"page":"464-471","source":"Crossref","is-referenced-by-count":0,"title":["Fungal colonization and ASCA\/p-ANCA positivity in inflammatory bowel disease: a cross-sectional study from Turkey"],"prefix":"10.3855","volume":"20","author":[{"given":"Z\u00fclal A\u015f\u00e7\u0131","family":"Toraman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"\u00d6ner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ber\u00e7em","family":"Af\u015far Karatepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-9492","authenticated-orcid":false,"given":"Abdurrahman","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-5510","authenticated-orcid":false,"given":"Yasemin","family":"\u00dcst\u00fcnda\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Akbulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2026,3,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21755\/3856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/21755\/3856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:24:28Z","timestamp":1776191068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/21755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.21755","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}