{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:48Z","timestamp":1786119348690,"version":"build-2736575974"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"07","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: The aim of this study was to analyze the clinical characteristics and risk factors of bloodstream infections (BSI) caused by extended-spectrum \u03b2-lactamase (ESBL)-producing Klebsiella pneumoniae (KP).\nMethodology: A retrospective study was conducted by enrolling clinically confirmed KP-BSI cases (2019\u20132023). Clinical data were collected and analyzed through review of the electronic medical records. Patients with ESBL-positive KP-BSI were compared to those with ESBL-negative KP-BSI. Multivariate logistic regression analysis was used to identify risk factors associated with ESBL-producing KP-BSI.\nResults: A total of 199 patients were included, among whom 47 (23.6%) had ESBL-producing KP-BSI. Univariate analysis revealed that the proportion of patients undergoing surgery within 48 hours before blood sampling was higher in the ESBL-positive group than in the ESBL-negative group (40.4% vs. 23.0%, p &lt; 0.05). Regarding infection source, liver-origin infections were less frequent in the ESBL-positive group compared to the ESBL-negative group (6.4% vs. 24.3%, p &lt; 0.05), while urinary tract-origin infections were significantly more frequent in the ESBL-positive group (38.3% vs. 18.4%, p &lt; 0.05). Hospital-acquired infection was more common in the ESBL-positive group than in the ESBL-negative group (40.4% vs. 23.7%, p &lt; 0.05). Multivariate analysis identified urinary tract origin (adjusted odds ratio [aOR], 2.162; 95% confidence interval [CI], 1.003\u20134.661) as an independent risk factor for ESBL-producing KP-BSI.\nConclusions: Primary urinary tract infections constitute an independent risk factor for ESBL-producing KP-BSI. Given the therapeutic complexity of ESBL-producing strains, KP-BSI of urinary tract origin warrant heightened clinical vigilance among clinicians.<\/jats:p>","DOI":"10.3855\/jidc.22258","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:57:38Z","timestamp":1786039058000},"page":"1021-1030","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors and clinical characteristics of bloodstream infection caused by ESBL-producing Klebsiella pneumoniae"],"prefix":"10.3855","volume":"20","author":[{"given":"Panpan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2026,7,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/22258\/3925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/22258\/3925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:57:38Z","timestamp":1786039058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/22258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2026,7,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.22258","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}