{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:37:12Z","timestamp":1769629032027,"version":"3.49.0"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with benzathine penicillin compared with doxycycline or tetracycline. Methodology: We examined rapid plasma regain (RPR) serological test results of all first-time early syphilis patients in Peking Union Medical College Hospital between 2000 and 2011, comparing treatment with two doses of penicillin to 14-day course of oral doxycycline (100 mg twice daily) or oral tetracycline (500 mg 4 times a day). Results: Of the 641 early syphilis cases with available treatment outcome data, 606 (94.5%) received penicillin and 35 (5.5%) received doxycycline\/tetracycline. More than half (52.1%) had secondary syphilis, 13.4% had primary syphilis, and 34.5% had early latent syphilis. A statistically similar serological treatment success rate (p = 0.157) was observed in penicillin-treated patients 91.4% (554\/606), when compared with patients treated with doxycycline\/tetracycline 82.9% (29\/35). Conclusion: Doxycycline\/tetracycline had a similar serological treatment success rate when compared to penicillin in the treatment of early syphilis.<\/jats:p>","DOI":"10.3855\/jidc.3013","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T08:35:53Z","timestamp":1392194153000},"page":"228-232","source":"Crossref","is-referenced-by-count":18,"title":["Early syphilis: serological treatment response to doxycycline\/tetracycline versus benzathine penicillin"],"prefix":"10.3855","volume":"8","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2014,2,13]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/24518634\/1007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/24518634\/1007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T04:16:16Z","timestamp":1562645776000},"score":1,"resource":{"primary":{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/view\/24518634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2014,2,12]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.3013","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]}}}