{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:02Z","timestamp":1760955722063},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: To evaluate the relationship between seropositivity to herpes virus family and liver function parameters in children from southwest China. Methodology: A 2-year cross-sectional retrospective study of 6,396 children aged 6 months to 12 years was performed. All participants underwent physical examination and liver function tests. Results: Of the children, 622 were positive for EBV, HSV, or CMV IgM, with dramatic changes in liver function parameters. Aspartate aminotransferase and alanine aminotransferase levels were negatively correlated with EBV-IgM and hepatocellular injuries in children &lt; 3 years of age, whereas a positive correlation between lactate dehydrogenase (LDH) and EBV-IgM and hepatocellular injuries was documented in children &lt; 1 year of age. In those &lt; 1 year and 3\u20136 years of age, HSV-IgM seropositivity was positively correlated with indirect bilirubin and \u03b3-glutamyl transferase. The percentage of children &lt; 1 year of age with positive CMV-IgM was 72.8% (158\/217), approximately five times higher than that in those 1\u20133 years. Sixty-three children were infected with two pathogens simultaneously. Abnormal levels of LDH were observed in 85.71% of children simultaneously infected with CMV and HSV, 77.78% for CMV and EBV, 83.33% for EBV and HSV, and irregular levels of AST were noted in 69.19% of children infected with CMV and HSV, 77.78% for CMV and EBV, and 83.33% for EBV and HSV. Conclusions: Seropositivity to herpes virus family was correlated with abnormal liver function parameters across years of age. Clinicians should aim to protect the liver function of children infected with herpes viruses.<\/jats:p>","DOI":"10.3855\/jidc.8089","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T19:05:16Z","timestamp":1493579116000},"page":"320-325","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between infection of herpes virus family and liver function parameters: a population-based cross-sectional study"],"prefix":"10.3855","volume":"11","author":[{"given":"Yali","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2017,4,30]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/28459223\/1688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/28459223\/1688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T04:15:57Z","timestamp":1561176957000},"score":1,"resource":{"primary":{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/view\/28459223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,30]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,4,30]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.8089","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,30]]}}}