{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T07:14:47Z","timestamp":1673594087704},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"08","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Class 1 integrons are mobile genetic elements considered to be responsible for the transfer of multidrug resistance. This study aimed to investigate the distribution of type 1 integrons in multidrug-resistantEscherichiacolifrom hospital-acquired lower respiratory tract infections.&#x0D;\nMethodology: Clinical strains of E. coli were isolated from patients with hospital-acquired lower respiratory tract infections in the emergency intensive care unit from January to December 2014. Drug sensitivity testing was performed using the Kirby-Bauer method. The combination disk method was used to detect extended-spectrum \u03b2-lactamase (ESBL), and polymerase chain reaction (PCR) amplification was used to detect the intI1 gene.&#x0D;\nResults: Among 58 E. coli strains, resistance to \u03b2-lactam antibiotics ranked as follows: imipenem (0.0%), cefoperazone\/sulbactam sodium (25.9%), ceftazidime (37.9%), and cefepime (39.7%); other \u03b2-lactam antibiotic resistance rates were all &gt; 50%. The resistance rates to amikacin, ciprofloxacin, gentamicin, and cotrimoxazole were32.8%, 63.8%, 70.7%, and 81.0%, respectively. In total, 31 (53.4%) isolates were positive for class 1 integron and carried 4 different sizes of amplification fragments: 800, 1,600, 1,900, and 2,600 bp. Among 43 ESBL-positive isolates, 27 (62.8%) also carried class 1 integron; among 15 ESBL-negative isolates, 4 carried class 1 integron (26.7%). The positive rate for class 1 integron in ESBL-producing strains was significantly higher than that in non-ESBL-producing strains. The rates of resistance of integron-positive isolates to ceftriaxone, cefotaxime, amikacin, ciprofloxacin, and cotrimoxazole were significantly higher than those in integron-negative isolates.&#x0D;\nConclusions: Class 1 integrons are widely distributed in E. coli and are associated with multidrug resistance.<\/jats:p>","DOI":"10.3855\/jidc.8247","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T07:18:55Z","timestamp":1504682335000},"page":"604-610","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between class 1 integron of Escherichia coli and multidrug resistance in lower respiratory tract infection"],"prefix":"10.3855","volume":"11","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingbing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2222","published-online":{"date-parts":[[2017,9,5]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/8247\/1733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/download\/8247\/1733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T04:27:12Z","timestamp":1561004832000},"score":1,"resource":{"primary":{"URL":"https:\/\/jidc.org\/index.php\/journal\/article\/view\/8247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2017,9,5]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.8247","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}