{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:36:24Z","timestamp":1788777384575,"version":"build-2803163510"},"reference-count":45,"publisher":"Korean Society for Therapeutic Radiology and Oncology","issue":"3","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-roj.org"],"crossmark-restriction":true},"short-container-title":["Radiat Oncol J"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Purpose: The study aims to report late toxicities in locally advanced head-and-neck squamous cell carcinoma (LAHNSCC) treated with intensity-modulated radiation therapy (IMRT).Materials and Methods: A retrospective study was conducted on 103 patients of LAHNSCC treated with IMRT. We analyzed the cumulative incidence of late xerostomia, dysphagia, and aspiration at an interval of 6-month, 1-year, 2-year, and 3-year from the start of IMRT.Results: At a median follow up of 4.2 years (interquartile range, 3.5 to 6 years), the cumulative incidence of grade \u22652 late xerostomia was 5.5%, dysphagia was 6.9%, and aspiration was 11.1%. Logistic regression showed that Dmean of \u226526 Gy to parotids had higher risk of xerostomia (hazard ratio [HR] = 5.19; 95% confidence interval [CI], 1.90\u201314.22; p = 0.001). Late dysphagia was associated with Dmean of \u226545 Gy to pharyngeal constrictors (PC) (HR = 7; 95% CI, 1.84\u201326.61; p =0.004),  \u226555 Gy to larynx (HR = 3.25; 95% CI, 1.15\u20139.11; p = 0.025), and adjuvant RT (HR = 5.26; 95% CI, 1.85\u201314.87; p = 0.002). Aspiration was associated with Dmean of \u226545 Gy to larynx (HR = 6.5; 95% CI, 1.93\u201321.88; p = 0.003), Dmean of \u226555 Gy to PC (HR = 3.54; 95% CI, 1.25\u20139.98; p = 0.017), and patients having late dysphagia (HR = 4.37; 95% CI, 1.55\u201312.31; p = 0.005).Conclusions: IMRT is a feasible radiation delivery technique in LAHNSCC with a decreased late toxicity profile.<\/jats:p>","DOI":"10.3857\/roj.2020.00913","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T06:57:46Z","timestamp":1631516266000},"page":"184-192","update-policy":"https:\/\/doi.org\/10.3857\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Late toxicities in locally advanced head and neck squamous cell carcinoma treated with intensity modulated radiation therapy"],"prefix":"10.3857","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-9087","authenticated-orcid":true,"given":"Sandeep","family":"Muzumder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Srikantia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash H.","family":"Udayashankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth Bhat","family":"Kainthaje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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