{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:06:30Z","timestamp":1791547590915,"version":"4.3.4"},"reference-count":24,"publisher":"Korean Society for Therapeutic Radiology and Oncology","issue":"3","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-roj.org"],"crossmark-restriction":true},"short-container-title":["Radiat Oncol J"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Purpose: To evaluate correlation of single photon emission computed tomography-computed tomography (SPECT-CT) data on lymph flow (LF) from oral tongue cancer (OC) and the topography of lymph nodes (LN) metastases; to determine the clinical value of lymph flow guided radiotherapy (LFGRT).Materials and methods: SPECT-CT visualization of LF from the OC lesions was performed after peritumoral injection of 99mTc-phytate in 26 primary patients with clinical stage cT1-2N0M0 disease. We determined the individual drainage (unilateral\/bilateral) from the tumor, and localization of sentinel LNs according to the neck levels. Metastases in LNs were verified with histology and a 2-year follow-up.Results: SPECT-CT detected bilateral LF in 10 (38.5%) of 26 patients; in 16 (61.5%) cases the drainage was unilateral. Histology revealed LNs metastases in three cases; regional recurrences were diagnosed in other four patients. In all seven observations metastases were located at the same site and level as the sentinel LNs. In eight (30.8%) of 26 patients sentinel LNs were visualized unilaterally at levels Ib\u2013IIa; in five cases, unilaterally at levels I\u2013IIa\u2013III. In these patients, LFGRT demonstrated 59%\u201370% reduction of irradiated volume, and 26%\u201342% and 51%\u201370% decrease of the mean dose to the spinal cord and the contralateral parotid gland. In patients with a bilateral drainage the reduction of doses absorbed by the spinal cord and contralateral parotid gland was 19% and 6%, respectively.Conclusions: Localization of sentinel LNs determined by SPECT-CT corresponds to the localization of metastatic LNs in terms of side and levels. <\/jats:p>","DOI":"10.3857\/roj.2021.00395","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T23:56:47Z","timestamp":1632441407000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.3857\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single photon emission computed tomography-computed tomography visualization of sentinel lymph nodes for lymph flow guided nodal irradiation in oral tongue cancer"],"prefix":"10.3857","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-1967","authenticated-orcid":true,"given":"Sergey Nikolaevich","family":"Novikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel Ivanovich","family":"Krzhivitskii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamira Achmedovna","family":"Radgabova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim Andreevitch","family":"Kotov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail Markovich","family":"Girshovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sergeevna","family":"Artemyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Sergeevna","family":"Melnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey Vasilevich","family":"Kanaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2224","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.3519"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215116000499"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.02.037"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1206-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.17.18301"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.04.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5050-0"},{"key":"ref9","first-page":"143","volume-title":"","author":"Neiweg","year":"2020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.047"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2014.06.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717x-9-121"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2018.05.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2016.10.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.010"},{"key":"ref16","first-page":"521","volume-title":"Elective versus therapeutic neck dissection in node-negative oral cancer","author":"D'Cruz","year":"2015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572585"},{"key":"ref18","first-page":"2777","volume-title":"Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer","author":"Schilling","year":"2015"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23019"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.03.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.03.012"},{"key":"ref22","first-page":"534","volume-title":"Sentinel node in oral cancer: the nuclear medicine aspects: a survey from the Sentinel European Node Trial","author":"Tartaglione","year":"2016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.07.008"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3933"}],"container-title":["Radiation Oncology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-roj.org\/upload\/pdf\/roj-2021-00395.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-roj.org\/journal\/view.php?doi=10.3857\/roj.2021.00395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-roj.org\/upload\/pdf\/roj-2021-00395.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T03:04:40Z","timestamp":1632971080000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-roj.org\/journal\/view.php?doi=10.3857\/roj.2021.00395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.3857\/roj.2021.00395","relation":{},"ISSN":["2234-1900","2234-3156"],"issn-type":[{"value":"2234-1900","type":"print"},{"value":"2234-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"assertion":[{"value":"2021-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-24","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}