{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:31:29Z","timestamp":1785306689215,"version":"3.55.0"},"reference-count":35,"publisher":"Korean Society for Therapeutic Radiology and Oncology","issue":"2","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-roj.org"],"crossmark-restriction":true},"short-container-title":["Radiat Oncol J"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Purpose: This study aimed to evaluate long-term tumor control, safety, and prognostic factors following single-fraction stereotactic radiosurgery (SRS) for vestibular schwannoma (VS).Materials and Methods: In this retrospective single-institution study, 68 patients with VS were treated with photon-based single-fraction SRS (mean dose, 13.1 Gy; range, 12 to 15 Gy). Treatment planning was based on computed tomography\u2013magnetic resonance imaging (MRI) fusion with organ-at-risk sparing and a planning target volume margin of 0\u20132 mm.  The primary endpoint was local control (LC). Secondary endpoints included toxicity and predictors of treatment failure.Results: After a median follow-up of 68 months, LC was maintained in 95.6% of patients. Actuarial LC rates at 5 and 10 years were both 98.5%. MRI showed tumor shrinkage in 41.2% and stability in 57.4% of cases. Treatment was well tolerated. Acute adverse events were infrequent and mild. Localized alopecia occurred acutely in one patient (1.5%) and did not persist into late follow-up.  Vertigo and tinnitus were analyzed as disease-related symptoms rather than treatment-related toxicities. Severe toxicity (grade \u2265 3) was rare (&lt;3%). Cox regression revealed no statistically significant predictors of local failure, though trends suggested higher risk after prior surgery and with doses \u226514 Gy.Conclusion: Single-fraction SRS provides durable long-term LC of VS with a favorable toxicity profile, supporting its role as a primary treatment modality. Optimal outcomes appear to be associated with lower prescription doses (&lt;14 Gy) and treatment of de novo tumors.<\/jats:p>","DOI":"10.3857\/roj.2026.00094","type":"journal-article","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T23:42:29Z","timestamp":1782085349000},"page":"97-106","update-policy":"https:\/\/doi.org\/10.3857\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of single-fraction radiosurgery in vestibular schwannoma: a 10-year experience"],"prefix":"10.3857","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8135-6387","authenticated-orcid":true,"given":"Kerem 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