{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:47:36Z","timestamp":1790732856539,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,30]]},"DOI":"10.3858\/emm.2010.42.11.074","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T04:38:57Z","timestamp":1289882337000},"page":"731-738","source":"Crossref","is-referenced-by-count":9,"title":["Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells"],"prefix":"10.1038","volume":"42","author":[{"given":"Gyesik","family":"Min","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, Jinju National University, Jinju 660-758, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,27]]},"reference":[{"key":"key20101115233530819_B1","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1016\/S0021-9258(19)89215-3","article-title":"Kinetics of estrogen-dependent modulation of apolipoprotein A-I synthesis in human hepatoma cells","volume":"261","author":"Archer","year":"1986","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B2","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1074\/jbc.M314111200","article-title":"Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice","volume":"279","author":"Assem","year":"2004","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(89)90237-7","article-title":"Gene regulation by steroid hormones","volume":"56","author":"Beato","year":"1989","journal-title":"Cell"},{"key":"key20101115233530819_B4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1749-6632.2001.tb04016.x","article-title":"Selective ER modulator effects on serum lipoproteins and vascular function in postmenopausal women and in hypercholesterolemic men","volume":"949","author":"Blum","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"key20101115233530819_B5","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.12.20.3195","article-title":"SXR, a novel steroid and xenobiotic-sensing nuclear receptor","volume":"12","author":"Blumberg","year":"1998","journal-title":"Genes Dev"},{"key":"key20101115233530819_B6","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1210\/endo.138.9.5404","article-title":"Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes","volume":"138","author":"Croston","year":"1997","journal-title":"Endocrinology"},{"key":"key20101115233530819_B7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"key":"key20101115233530819_B8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors and human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J Clin Invest"},{"key":"key20101115233530819_B9","first-page":"1511","article-title":"Transcriptional activation of c-fos protooncogene by17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition","volume":"13","author":"Duan","year":"1999","journal-title":"Mol Endocrinol"},{"key":"key20101115233530819_B10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone receptor superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"key":"key20101115233530819_B11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/26996","article-title":"Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta","volume":"395","author":"Forman","year":"1998","journal-title":"Nature"},{"key":"key20101115233530819_B12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.physiol.65.092101.142528","article-title":"Nuclear receptors and the control of metabolism","volume":"65","author":"Francis","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"key20101115233530819_B13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0092-8674(88)90194-8","article-title":"The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements","volume":"54","author":"Glass","year":"1988","journal-title":"Cell"},{"key":"key20101115233530819_B14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1172\/JCI27913","article-title":"Going nuclear in metabolic and cardiovascular disease","volume":"116","author":"Glass","year":"2006","journal-title":"J Clin Invest"},{"key":"key20101115233530819_B15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0165-6147(92)90107-H","article-title":"Human cytochromes P450: problems and prospects","volume":"13","author":"Gonzalez","year":"1992","journal-title":"Trends Pharmacol Sci"},{"key":"key20101115233530819_B16","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B17","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1128\/MCB.18.10.5652","article-title":"The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene","volume":"18","author":"Honkakoski","year":"1998","journal-title":"Mol Cell Biol"},{"key":"key20101115233530819_B18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/hep.20164","article-title":"Tamoxifen in treatment of primary biliary cirrhosis","volume":"39","author":"Invernizzi","year":"2004","journal-title":"Hepatology"},{"key":"key20101115233530819_B19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0168-8278(02)00129-0","article-title":"Nuclear receptor regulation of hepatic function","volume":"36","author":"Karpen","year":"2002","journal-title":"J Hepatol"},{"key":"key20101115233530819_B20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/bcr78","article-title":"Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer","volume":"2","author":"Katzenellenbogen","year":"2000","journal-title":"Breast Cancer Res"},{"key":"key20101115233530819_B21","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/MCB.19.9.6318","article-title":"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene","volume":"19","author":"Kawamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key20101115233530819_B22","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1074\/jbc.M008090200","article-title":"Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)\/retinoid X receptor (RXR) and enhances CAR\/RXR-mediated activation of the PBRU","volume":"276","author":"Kim","year":"2001","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B23","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1126\/science.284.5415.757","article-title":"Orphan nuclear receptors: shifting endocrinology into reverse","volume":"284","author":"Kliewer","year":"1999","journal-title":"Science"},{"key":"key20101115233530819_B24","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/0140-6736(91)92302-I","article-title":"First-pass metabolism of cyclosporin by the gut","volume":"338","author":"Kolars","year":"1991","journal-title":"Lancet"},{"key":"key20101115233530819_B25","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1128\/MCB.15.4.1847","article-title":"Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist-and antagonist-occupied progestin receptors","volume":"15","author":"Kraus","year":"1995","journal-title":"Mol Cell Biol"},{"key":"key20101115233530819_B26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/dna.1998.17.461","article-title":"Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1\/2","volume":"17","author":"Liu","year":"1998","journal-title":"DNA Cell Biol"},{"key":"key20101115233530819_B27","doi-asserted-by":"crossref","first-page":"20164","DOI":"10.1074\/jbc.M702895200","article-title":"A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor","volume":"282","author":"Matsukuma","year":"2007","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B28","doi-asserted-by":"crossref","first-page":"26356","DOI":"10.1074\/jbc.M200051200","article-title":"Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vitro","volume":"277","author":"Min","year":"2002","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B29","doi-asserted-by":"crossref","first-page":"34626","DOI":"10.1074\/jbc.M205239200","article-title":"Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR)","volume":"277","author":"Min","year":"2002","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B30","doi-asserted-by":"crossref","first-page":"9189","DOI":"10.1074\/jbc.271.16.9189","article-title":"The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling","volume":"271","author":"Miyata","year":"1996","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B31","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1074\/jbc.M001215200","article-title":"Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands","volume":"275","author":"Moore","year":"2000","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0303-7207(96)03980-9","article-title":"Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor","volume":"127","author":"Nu\u00f1ez","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"key20101115233530819_B33","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.277.5331.1508","article-title":"Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites","volume":"277","author":"Paech","year":"1997","journal-title":"Science"},{"key":"key20101115233530819_B34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1478-3231.2004.00920.x","article-title":"Tamoxifen: a novel treatment for primary biliary cirrhosis?","volume":"24","author":"Reddy","year":"2004","journal-title":"Liver Int"},{"key":"key20101115233530819_B35","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1074\/jbc.274.6.3430","article-title":"Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells","volume":"274","author":"Ricci","year":"1999","journal-title":"J Biol Chem"},{"key":"key20101115233530819_B36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/hep.1840030422","article-title":"Estrogen-induced cholestasis: clues to pathogenesis and treatment","volume":"3","author":"Schreiber","year":"1983","journal-title":"Hepatology"},{"key":"key20101115233530819_B37","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20101115233530819_B38","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1073\/pnas.0409794102","article-title":"Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury","volume":"102","author":"Stedman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20101115233530819_B39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-1119(94)00916-G","article-title":"Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene","volume":"158","author":"Trottier","year":"1995","journal-title":"Gene"},{"key":"key20101115233530819_B40","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1128\/MCB.20.9.2951-2958.2000","article-title":"The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR","volume":"20","author":"Tzameli","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key20101115233530819_B41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/hep.20512","article-title":"Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice","volume":"41","author":"Uppal","year":"2005","journal-title":"Hepatology"},{"key":"key20101115233530819_B42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature"},{"key":"key20101115233530819_B43","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes Dev"},{"key":"key20101115233530819_B44","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.051014398","article-title":"An essential role for nuclear receptors SXR\/PXR in detoxification of cholestatic bile acids","volume":"98","author":"Xie","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20101115233530819_B45","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1074\/jbc.M602723200","article-title":"Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity","volume":"281","author":"Yamamoto","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Experimental and Molecular Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T23:12:07Z","timestamp":1684624327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/doifinder\/10.3858\/emm.2010.42.11.074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,27]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,9,27]]},"published-print":{"date-parts":[[2010,11,30]]}},"alternative-id":["10.3858\/emm.2010.42.11.074"],"URL":"https:\/\/doi.org\/10.3858\/emm.2010.42.11.074","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,27]]}}}