{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T19:05:16Z","timestamp":1767207916083,"version":"build-2238731810"},"reference-count":21,"publisher":"Scientific Foundation Spiroski (publications)","issue":"1","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis.\r\nAIM: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases.\r\nMATERIAL AND METHODS: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&amp;D Systems Europe, Abingdon, UK).\r\nRESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg\/ml (413 \u00e2\u20ac\u201c 1620 pg\/ml) and 1309 (403) pg\/ml (540 \u00e2\u20ac\u201c 2430 pg\/ml), while in normal sTNF-R1 and sTNF \u00e2\u20ac\u201c R2 levels were 740 (340) pg\/ml (407-1240 pg\/ml) and 1283 (414) pg (480 \u00e2\u20ac\u201c 2340 pg\/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF \u00e2\u20ac\u201c R2 and apical periodontitis.\r\nCONCLUSION: Elevated levels of sTNF-R1 and sTNF \u00e2\u20ac\u201c R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.<\/jats:p>","DOI":"10.3889\/oamjms.2017.010","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:20:24Z","timestamp":1484612424000},"page":"68-71","source":"Crossref","is-referenced-by-count":5,"title":["Retracted: sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease"],"prefix":"10.3889","volume":"5","author":[{"given":"Rajnish K.","family":"Singhal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwant","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"52292","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"27870","unstructured":"Rai B, Anand SC, Kharb S. 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