{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:56:49Z","timestamp":1790661409552,"version":"4.1.0"},"reference-count":24,"publisher":"Scientific Foundation Spiroski (publications)","issue":"3","license":[{"start":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T00:00:00Z","timestamp":1497052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.RESULTS: In this study, the mean age of the participants was 2.55 \u00c2\u00b1 14.26 and 3.19 \u00c2\u00b1 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.<\/jats:p>","DOI":"10.3889\/oamjms.2017.050","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T19:34:13Z","timestamp":1497468853000},"page":"305-309","source":"Crossref","is-referenced-by-count":21,"title":["Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata"],"prefix":"10.3889","volume":"5","author":[{"given":"Javad","family":"Ghaffari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem Rahmatpour","family":"Rokni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaghan","family":"Kazeminejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Abedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52292","published-online":{"date-parts":[[2017,6,10]]},"reference":[{"key":"31899","doi-asserted-by":"crossref","unstructured":"Hordinsky MK. Overview of Alopecia Areata. Journal of Investigative Dermatology Symposium Proceedings. 2013;16:s13-s5. https:\/\/doi.org\/10.1038\/jidsymp.2013.4 PMid:24326541","DOI":"10.1038\/jidsymp.2013.4"},{"key":"31900","unstructured":"Ghaffari J, Aarabi M. The prevalence of pediatric asthma in the Islamic Republic of Iran: A systematic review and meta-analysis. J Pediatr Rev. 2013;1(1)2-11."},{"key":"31901","unstructured":"Ghaffari J, Navaeifar MR, Alizadeh-Navaei R. The prevalence of Eczema in Iranian children: A systematic review and meta-analysis. J Pediatr Rev. 2014;2(1):2-9."},{"key":"31902","doi-asserted-by":"crossref","unstructured":"Golpour M, Ghaffari J, Dabbaghzadeh A, Rezaiefard J. Management of Children with Atopic Dermatitis: A Narrative Review.J Pediatr Rev. 2017 January; 5(1):e7474.","DOI":"10.17795\/jpr-7474"},{"key":"31903","doi-asserted-by":"crossref","unstructured":"Goh C FM, Christos P, Sinha A. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. Eur Acad Dermatol Venereol. 2006;20:1055-60. https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01676.x PMid:16987257","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"key":"31904","doi-asserted-by":"crossref","unstructured":"Regina C. Betz JP, Antonia Flaquer, Silke Redler, Sandra Hanneken, Sibylle Eigelshoven, et al. Nothen. Loss-of-Function Mutations in the Filaggrin Gene and Alopecia Areata: Strong Risk Factor for a Severe Course of Disease in Patients Comorbid for Atopic Disease. Journal of Investigative Dermatology Symposium Proceedings. 2007; 127: 2359-543.","DOI":"10.1038\/sj.jid.5700915"},{"key":"31905","doi-asserted-by":"crossref","unstructured":"Saylam Kurtipek G, Cihan FG, Erayman Demirba\u00c5\u0178 \u00c5\u017e, Ataseven A. The Frequency of Autoimmune Thyroid Disease in Alopecia Areata andVitiligo Patients. Biomed Res Int. 2015; 2015:435947. https:\/\/doi.org\/10.1155\/2015\/435947 PMid:26355833 PMCid:PMC4555361","DOI":"10.1155\/2015\/435947"},{"key":"31906","doi-asserted-by":"crossref","unstructured":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama. 2013; 310 (20): 2191-4. https:\/\/doi.org\/10.1001\/jama.2013.281053 PMid:24141714","DOI":"10.1001\/jama.2013.281053"},{"key":"31907","doi-asserted-by":"crossref","unstructured":"Tobin DJ, Orentreich N, Fenton DA, Bystryn JC. Antibodies to hair follicles in alopecia areata. Invest Dermatol. 1994; 102(5): 721-4. https:\/\/doi.org\/10.1111\/1523-1747.ep12375477","DOI":"10.1111\/1523-1747.ep12375477"},{"key":"31908","unstructured":"Manzoor S, Masood C. Alopecia areata in Kashmir: A study of 200 patients. Indian J Dermatol Venereol Leprol. 2001; 67: 324-5. PMid:17664789"},{"key":"31909","doi-asserted-by":"crossref","unstructured":"Serarslan G Savas N, Yenin JZ. Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study. Journal of the European Academy of Dermatology and Venereology. 2012; 26(6):720-3. https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04152.x PMid:21692870","DOI":"10.1111\/j.1468-3083.2011.04152.x"},{"key":"31910","doi-asserted-by":"crossref","unstructured":"Gilhar A Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest. 2007; 117: 2019-27. https:\/\/doi.org\/10.1172\/JCI31942 PMid:17671634 PMCid:PMC1934574","DOI":"10.1172\/JCI31942"},{"key":"31911","doi-asserted-by":"crossref","unstructured":"Muller SA, Winkelmann RK. Alopecia Areata. An Evaluation of 736 Patients. Arch Dermatol. 1963 88:290-7. https:\/\/doi.org\/10.1001\/archderm.1963.01590210048007 PMid:14043621","DOI":"10.1001\/archderm.1963.01590210048007"},{"key":"31912","doi-asserted-by":"crossref","unstructured":"Lugogo NL Kraft M. Epidemiology of asthma. 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