{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:16:25Z","timestamp":1770963385848,"version":"3.50.1"},"reference-count":24,"publisher":"Scientific Foundation Spiroski (publications)","issue":"3","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: It\u00e2\u20ac\u2122s assumed that surgery in haemophilia can be accomplished these days safely.AIM: The aim of this study was to investigate the influence of new surgical technologies in the perioperative management and outcome of surgical procedures in haemophiliacs.METHODS: Two patients with mild haemophilia A underwent surgery (laparoscopic appendectomy and inguinal hernia repair). In both patients, the replacement therapy, with factor VIII, started 30 min before surgery. We used the available surgical technologies and techniques with a proven value in the best clinical practice, to achieve proper and permanent hemostasis. Postoperatively, the replacement therapy and thromboembolic prophylaxis was continued according to the international guidelines for the management of haemophilia.RESULTS: The operative and post-operative periods were uneventful. No significant differences were found in the operation time in our hemophilic patients versus non-hemophilic patients. Significant differences related to the hospital stay duration were found in both patients compared with controls, due to the necessary replacement therapy.CONCLUSION: With new surgical technologies, proper and permanent hemostasis can be achieved, without prolonging the operation time.<\/jats:p>","DOI":"10.3889\/oamjms.2017.062","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T19:34:13Z","timestamp":1497468853000},"page":"295-298","source":"Crossref","is-referenced-by-count":2,"title":["New Surgical Technologies Could Facilitate Surgical Hemostasis in Hemophilic Patients"],"prefix":"10.3889","volume":"5","author":[{"given":"Milcho J.","family":"Panovski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor V.","family":"Fildishevski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubomir Lj.","family":"Ognjenovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta I.","family":"Dejanova-Ilijevska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"52292","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"31746","doi-asserted-by":"crossref","unstructured":"Bastounis E, Pikoulis E, Lepp\u00c3\u00a4niemi A, Alexiou D, Tsigris C, Tsetis A. General surgery in haemophiliac patients. Postgraduet Med J. 2000;76;494-495. https:\/\/doi.org\/10.1136\/pmj.76.898.494 PMid:10908378 PMCid:PMC1741703","DOI":"10.1136\/pmj.76.898.494"},{"key":"31747","doi-asserted-by":"crossref","unstructured":"Inokawa Y, Sugimoto H, Kanda M, Yamada S, Fujii T, Nomoto S, Takeda S, Suzuki N, Matsushita T, Kodera Y. Hepatectomy for hepatocellular carcinoma in patients with hemophilia. J Hepatobiliary Pancreat Sci. 2014; 21(11):824-8. https:\/\/doi.org\/10.1002\/jhbp.142 PMid:25082726","DOI":"10.1002\/jhbp.142"},{"key":"31748","doi-asserted-by":"crossref","unstructured":"Shapiro A, Cooper DL. U.S. survey of surgical capabilities and experience with surgical procedures in patients with congenital haemophilia with inhibitors. Haemophilia. 2012; 18(3):400-5. https:\/\/doi.org\/10.1111\/j.1365-2516.2011.02698.x PMid:22168829","DOI":"10.1111\/j.1365-2516.2011.02698.x"},{"key":"31749","doi-asserted-by":"crossref","unstructured":"Leissinger C, Kruse-Jarres R. General Surgical Management of Patients with Hemophilia. in Textbook of Hemophilia, 3. Editor(s): Christine A. Lee, Erik E. Berntorp, W. Keith Hoots, 2014:197\u00e2\u20ac\u201c203.","DOI":"10.1002\/9781118398258.ch28"},{"key":"31750","unstructured":"Rudowski WJ. Major surgery in hemophilia. Moynihan lecture 1980. Ann R Coll Surg Engl. 2981; 63; 110-117."},{"key":"31751","unstructured":"Karaman MI, Zulfikar B, \u00c3\u2013zturk MI, Koca O, Aky\u00c3\u00bcz M, Bezgal F. Circumcision in bleeding disorders: improvement of our cost effective method with diathermic knife. Urol J. 2014; 6;11(2):1406-10."},{"key":"31752","doi-asserted-by":"crossref","unstructured":"Rodriguez-Merchan EC. Local fibrin glue and chitosan-based dressings in haemophilia surgery. Blood Coagul Fibrinolysis. 2012; 23(6):473-6. https:\/\/doi.org\/10.1097\/MBC.0b013e3283555379 PMid:22688558","DOI":"10.1097\/MBC.0b013e3283555379"},{"key":"31753","unstructured":"Panovski M. Electrosurgery. Tabernakul, Skopje, 2013. 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Definitions in hemophilia: communication from the SSC of the ISTH. J Thromb Haemost. 2014; 12(11):1935-9. https:\/\/doi.org\/10.1111\/jth.12672 PMid:25059285","DOI":"10.1111\/jth.12672"},{"key":"31757","doi-asserted-by":"crossref","unstructured":"Arya S, Mackenzie H, Hanna GB. Non-vascular experimental and clinical applications of advanced bipolar radiofrequency thermofusion technology in the thorax and abdomen: a systematic review. Surg Endosc. 2015; 29(7):1659-78. https:\/\/doi.org\/10.1007\/s00464-014-3893-z PMid:25407912","DOI":"10.1007\/s00464-014-3893-z"},{"key":"31758","unstructured":"Guidelines for the management of hemophilia. 2nd edition. Prepared by the Treatment Guidelines Working Group, on behalf of the World Federation of Hemophilia (WFH) Available from: http:\/\/ www.wfh.org"},{"key":"31759","unstructured":"Guidelines for Diagnostic Laparoscopy. SAGES. 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