{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:23:04Z","timestamp":1783200184784,"version":"3.54.6"},"reference-count":16,"publisher":"Scientific Foundation Spiroski (publications)","issue":"3","license":[{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity.\u00c2\u00a0Aim : To determine correlation between serum homocysteine and vitiligo area scoring index (VASI)Subject and method: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood\u00e2\u20ac\u2122s lamp examinations then VASI score was determined and same numbers of control. We conducted blood sampling and measurement of serum homocysteine level to the patients.Results: There is no significant correlation between serum homocysteine and VASI score (p= 0,133, r= 0,281), family history (p=0,447), and duration of vitiligo (p= 0,993, r= 0,002). There is no significant difference between serum homocysteine in vitiligo patients and controls (p= 0,191). There is a correlation between serum homocysteine with gender (p= 0,001) and age (p= 0,036;r= 0,385) \u00c2\u00a0in vitiligo patient but not in controls (p= 0,266), (p= 0,872; r= 0,031). There is a correlation between serum homocysteine and types of vitiligo.\u00c2\u00a0Conclusion: There is no significant correlation between serum homocysteine and VASI score, family history, and duration of vitiligo. There is no significant difference between serum homocysteine in vitiligo patients and controls. There is a correlation between serum homocysteine with gender and age in vitiligo patients.<\/jats:p>","DOI":"10.3889\/oamjms.2017.066","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T19:34:13Z","timestamp":1497468853000},"page":"332-334","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between Serum Homocysteine and Vitiligo Area Scoring Index"],"prefix":"10.3889","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-9663","authenticated-orcid":false,"given":"Dina R. U.","family":"Hasibuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam B.","family":"Putra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelva K.","family":"Jusuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52292","published-online":{"date-parts":[[2017,6,11]]},"reference":[{"key":"32080","doi-asserted-by":"crossref","unstructured":"Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: A comprehensive overview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65:473-91. https:\/\/doi.org\/10.1016\/j.jaad.2010.11.061 PMid:21839315","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"32081","unstructured":"Birlea SA, Spritz RA, Noris DA. Vitiligo. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, Wolff K,editors. Fitzpatrick's dermatology in general medicine. 8th ed. New York: The MCGraw-Hill companies, 2012: p. 1308-24."},{"key":"32082","doi-asserted-by":"crossref","unstructured":"Yaghoobi R, Omidian M, Bagherani N. Vitiligo: A review of the published work. Journal of Dermatology. 2011;38:419-31. https:\/\/doi.org\/10.1111\/j.1346-8138.2010.01139.x PMid:21667529","DOI":"10.1111\/j.1346-8138.2010.01139.x"},{"key":"32083","doi-asserted-by":"crossref","unstructured":"Karadag AS, Tutal E, Ertugrul DT, Akint KO, Bilgili SG. Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in patients with vitiligo. Clin Exp Dermatol. 2011; 37: 62-4. https:\/\/doi.org\/10.1111\/j.1365-2230.2011.04142.x PMid:22182436","DOI":"10.1111\/j.1365-2230.2011.04142.x"},{"key":"32084","unstructured":"Bolander-Gouaille C. Homocysteine, the new marker of disease risk-an overview. Business briefing: European pharmacotherapy. 2005;2-8."},{"key":"32085","doi-asserted-by":"crossref","unstructured":"Agarwal S, Mendiratta V, Chander R, Jain A, Yadav P. Study of serum levels of Vitamin B, folic acid, and homocysteine in vitiligo. Pigment Int. 2015;2:76-80. https:\/\/doi.org\/10.4103\/2349-5847.172777","DOI":"10.4103\/2349-5847.172777"},{"key":"32086","unstructured":"Elhuda. Hubungan kadar homosistei serum dengan skor vitiligo area scoring index (VASI) . Sp. DV [ Tesis]. Padang: Universitas Andalas, 2016."},{"key":"32087","unstructured":"Zaki AM, Abdo HM, Ibrahim IM, Ibrahim AEKI. Serum homocysteine and vitiligo. The gulf journal of dermatology and venereology. 2014 ;21(2): 15-20."},{"key":"32088","unstructured":"El-Dawela RE, Abou-elfetouh S. Relationship between homocysteine, vitamin B12, folic acid levels and vitiligo. J Appl Sci Res. 2012; 8(11): 5528-35."},{"key":"32089","doi-asserted-by":"crossref","unstructured":"Sabry HH, Sabry JH, Hashim HM. Serum levels of homocysteine, vitamin B12, and folic acid in vitiligo. Egypt J Dermatol Venerol. 2014;34:65-9. https:\/\/doi.org\/10.4103\/1110-6530.137315","DOI":"10.4103\/1110-6530.137315"},{"key":"32090","doi-asserted-by":"crossref","unstructured":"Becatti M, Prigano F, Fiorillo, Pescitelli L, Nassi P, Lotti T, Taddei N.The involvement of Smac\/DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligft skin: protective effects of curcumin and capsaicin. Antioxidants & Redox Signaling. 2010; 13(9):1309-21. https:\/\/doi.org\/10.1089\/ars.2009.2779 PMid:20085492","DOI":"10.1089\/ars.2009.2779"},{"key":"32091","doi-asserted-by":"crossref","unstructured":"Yu H, Chang K, Yu C, Li H, Wu M, Wu C,et al. Alterations in IL-6, IL-8, GM-CSF, TNF-a, and IFNy release by peripheral mononuclear cells in patients with active vitiligo. J invest Dermatol. 1997;108: 527 -9. https:\/\/doi.org\/10.1111\/1523-1747.ep12289743 PMid:9077486","DOI":"10.1111\/1523-1747.ep12289743"},{"key":"32092","doi-asserted-by":"crossref","unstructured":"Ghalamkarpour F Jafarian Z, Einollahi H, Younespour S. Homocysteine: is it a biomarker for vitiligo? Journal of pigmentary disorders. 2015; 2(4): 1-4.","DOI":"10.4172\/2376-0427.1000172"},{"key":"32093","doi-asserted-by":"crossref","unstructured":"Silverberg JI, Silverberg NB. Serum homocysteine as a biomarker of vitiligo vulgaris severity: A pilot study. J Am Acad Dermatbl. 2011. 64(2):445-7. https:\/\/doi.org\/10.1016\/j.jaad.2010.08.025 PMid:21238838","DOI":"10.1016\/j.jaad.2010.08.025"},{"key":"32094","doi-asserted-by":"crossref","unstructured":"Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999; 19:217-46. https:\/\/doi.org\/10.1146\/annurev.nutr.19.1.217 PMid:10448523","DOI":"10.1146\/annurev.nutr.19.1.217"},{"key":"32095","doi-asserted-by":"crossref","unstructured":"Singh S, Singh U, Pandey SS. Serum folic acid, vitamin B12 and homocysteine levels in Indian vitiligo patients. EDOJ. 2012; 8(1):1-7.","DOI":"10.4103\/0019-5154.92668"}],"container-title":["Open Access Macedonian Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2017.066\/1391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2017.066\/1412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:04:47Z","timestamp":1744700687000},"score":1,"resource":{"primary":{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/view\/oamjms.2017.066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,11]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,4,13]]}},"URL":"https:\/\/doi.org\/10.3889\/oamjms.2017.066","relation":{},"ISSN":["1857-9655"],"issn-type":[{"value":"1857-9655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,11]]}}}