{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:06:39Z","timestamp":1777712799929,"version":"3.51.4"},"reference-count":0,"publisher":"Scientific Foundation Spiroski (publications)","issue":"11","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>AIM: This study aimed to evaluate the importance of IFN-\u03b3 in the diagnosis of pediatric TB and LTBI and to compare the IFN-\u03b3 levels.\r\nMETHODS: We analysed 100 patients examined for possible M. tuberculosis infection or disease at the Institute of Respiratory Diseases in Children, Kozle, Skopje. Patients were divided into 2 groups: TB disease and LTBI. The following parameters were analyzed: demographic characteristics, history of previous exposure to active TB, BCG vaccination and presence of BCG scar, lung X-ray findings, tuberculin skin test by the Monteux method and the value of INF -\u03b3 according to the Quantiferon TB gold test, direct samples of acid-alcohol-resistant bacilli of sputum and L\u00f6wenstein Jensen cultures. Informed parental consent was obtained for each child included in the study.\r\nRESULTS: In the LTBI group 60.9% had a scar from the vaccination while in the TB group 50% had BCG scar. TST induration diameters in children with or without BCG scar were significantly larger in patients with active TB. Children with active TB had significantly higher IFN-\u03b3 levels than children with LTBI. The IFN-\u03b3 for the cut-off of 0.35 IU\/ml, has 64% sensitivity for detection of LTBI, versus 80.6% sensitivity for active disease. Children with close TB contact had significantly higher IFN-\u03b3 levels. Correlation between TST induration diameter and IFN-\u03b3 levels was stronger in the TB group.\r\nCONCLUSION: IFN-\u03b3 levels are significantly higher in children with active TB, and children with close contact with TB patient. It has better sensitivity in active TB. Using both tests (IFN-\u03b3 and TST) can improve the diagnose of LTBI and TB in countries where vaccination with BCG is widespread.<\/jats:p>","DOI":"10.3889\/oamjms.2018.467","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T10:04:53Z","timestamp":1543313093000},"page":"2091-2096","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of IFN-\u03b3 Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI)"],"prefix":"10.3889","volume":"6","author":[{"given":"Katerina","family":"Boskovska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stojka","family":"Naceva-Fustic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liljana","family":"Simonovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Dilberovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Dacevski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorica","family":"Popova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Arnaudova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Cakalarovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"52292","published-online":{"date-parts":[[2018,11,20]]},"container-title":["Open Access Macedonian Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/download\/oamjms.2018.467\/2647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2018.467\/2591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T21:27:25Z","timestamp":1681939645000},"score":1,"resource":{"primary":{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/view\/oamjms.2018.467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,25]]}},"URL":"https:\/\/doi.org\/10.3889\/oamjms.2018.467","relation":{},"ISSN":["1857-9655"],"issn-type":[{"value":"1857-9655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]}}}