{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:30:51Z","timestamp":1759332651303,"version":"3.36.0"},"reference-count":16,"publisher":"Scientific Foundation Spiroski (publications)","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1).\r\nAIM: The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test.\r\nMETHOD: Forty patients with Pemphigus include 36 PV and 4 PF (28 women, 12 women) were enrolled. The titers of Dsg in pemphigus patients by using ELISA test were done before and 1-month treatment\r\nRESULTS: Both anti-Dsg1 and anti-Dsg3 levels were significantly reduced after treatment (P &lt; 0.05). The severity of skin lesions was correlated with anti-Dsg1 antibody level and the severity of oral lesions was significantly correlated with anti-Dsg 3 antibody levels (p &lt; 0.05)\r\nCONCLUSION: It is recommended that we can predict and improve the outcome of treatment by using Desmoglein ELISA test.<\/jats:p>","DOI":"10.3889\/oamjms.2019.003","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T08:43:08Z","timestamp":1548751388000},"page":"195-197","source":"Crossref","is-referenced-by-count":5,"title":["Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test"],"prefix":"10.3889","volume":"7","author":[{"given":"Anh Tran","family":"Thi Van","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuong","family":"Van Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sau","family":"Nguyen Huu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Pham Thi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Pham","family":"Thi Minh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nghi","family":"Dinh Huu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Tran","family":"Cam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My","family":"Le Huyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh","family":"Vu Nguyet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khang","family":"Tran Hau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Satolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Feliciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tirant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Vojvodic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"52292","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. The Journal of Immunology. 1997; 159(4):2010-7. PMid:9257868","key":"61949","DOI":"10.4049\/jimmunol.159.4.2010"},{"doi-asserted-by":"crossref","unstructured":"Lenz P, Amagai M, Volc-Platzer B, Stingl G, Kirnbauer R. Desmoglein 3-ELISA: a pemphigus vulgaris\u00e2\u20ac\u201cspecific diagnostic tool. Archives of dermatology. 1999; 135(2):143-8. https:\/\/doi.org\/10.1001\/archderm.135.2.143 PMid:10052398","key":"61950","DOI":"10.1001\/archderm.135.2.143"},{"doi-asserted-by":"crossref","unstructured":"Harman KE, Gratian MJ, Seed PT, Bhogal BS, Challacombe SJ, Black MM. Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3: Experimental dermatology\u00e2\u20ac\u00a2 Original article. Clinical and experimental dermatology. 2000; 25(3):236-40. https:\/\/doi.org\/10.1046\/j.1365-2230.2000.00624.x PMid:10844505","key":"61951","DOI":"10.1046\/j.1365-2230.2000.00624.x"},{"doi-asserted-by":"crossref","unstructured":"Daneshpazhooh M, Chams\u00e2\u20ac\u0090Davatchi C, Khamesipour A, Mansoori P, Taheri A, Firooz A, Mortazavi H, Esmaili N, Dowlati Y. Desmoglein 1 and 3 enzyme\u00e2\u20ac\u0090linked immunosorbent assay in Iranian patients with pemphigus vulgaris: correlation with phenotype, severity, and disease activity. Journal of the European Academy of Dermatology and Venereology. 2007; 21(10):1319-24. https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02254.x PMid:17958835","key":"61952","DOI":"10.1111\/j.1468-3083.2007.02254.x"},{"doi-asserted-by":"crossref","unstructured":"Anand V, Khandpur S, Sharma VK, Sharma A. Utility of desmoglein ELISA in the clinical correlation and disease monitoring of pemphigus vulgaris. 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European Journal of Dermatology. 2013; 23(1):33-9. PMid:23302186","key":"61955","DOI":"10.1684\/ejd.2012.1901"},{"unstructured":"Marinovi\u00c4\u2021 B, Fabris Z, \u00c5 tulhofer-Buzina D, Lako\u00c5\u00a1 Juki\u00c4\u2021 I. Comparison of diagnostic value of indirect immunofluorescence assay and desmoglein ELISA in the diagnosis of pemphigus. Acta dermatovenerologica Croatica. 2010; 18(2):79-83. PMid:20624356","key":"61956"},{"doi-asserted-by":"crossref","unstructured":"Schmidt E, D\u00c3\u00a4hnrich C, Rosemann A, Probst C, Komorowski L, Saschenbrecker S, Schlumberger W, St\u00c3\u00b6cker W, Hashimoto T, Br\u00c3\u00b6cker EB, Recke A. Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients. 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