{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:09:53Z","timestamp":1779185393931,"version":"3.51.4"},"reference-count":9,"publisher":"Scientific Foundation Spiroski (publications)","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>AIM: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris.\r\nMETHODS: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment.\r\nRESULTS: The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group.\r\nCONCLUSION: In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.<\/jats:p>","DOI":"10.3889\/oamjms.2019.054","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T08:43:08Z","timestamp":1548751388000},"page":"217-220","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients"],"prefix":"10.3889","volume":"7","author":[{"given":"Thuong Nguyen","family":"Van","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Duong Thi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Nguyen Trong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tro","family":"Chau Van","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang","family":"Trinh Minh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Pham","family":"Thi Minh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nghi","family":"Dinh Huu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Tran","family":"Cam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My","family":"Le Huyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khang","family":"Tran Hau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Satolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Feliciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tirant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Vojvodic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"52292","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"62121","doi-asserted-by":"crossref","unstructured":"Knutsen-Larson S, Dawson AL, Dunnick CA, Dellavalle RP. Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatologic Clinics. 2012; 30(1):99-106. https:\/\/doi.org\/10.1016\/j.det.2011.09.001","DOI":"10.1016\/j.det.2011.09.001"},{"key":"62122","doi-asserted-by":"crossref","unstructured":"Lee HE, Chang IK, Lee Y, Kim CD, Seo YJ, Lee JH, Im M. Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study. Journal of the European Academy of Dermatology and Venereology. 2014; 28(12):1654-60. https:\/\/doi.org\/10.1111\/jdv.12403","DOI":"10.1111\/jdv.12403"},{"key":"62123","unstructured":"Tanghetti EA. The role of inflammation in the pathology of acne. The Journal of clinical and aesthetic dermatology. 2013; 6(9):27. PMCid:PMC3780801"},{"key":"62124","doi-asserted-by":"crossref","unstructured":"Yosef A, Dawoud NM, Gharib K. Preliminary evaluation of the clinical efficacy of antihistamines as an adjuvant treatment to isotretinoin for acne vulgaris. Journal of the Egyptian Women's Dermatologic Society. 2017;14(1):49-55. https:\/\/doi.org\/10.1097\/01.EWX.0000503398.22746.59","DOI":"10.1097\/01.EWX.0000503398.22746.59"},{"key":"62125","doi-asserted-by":"crossref","unstructured":"Schroeder JT, Schleimer RP, Lichtenstein LM, Kreutner W. Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clinical & Experimental Allergy. 2001; 31(9):1369-77. https:\/\/doi.org\/10.1046\/j.1365-2222.2001.01130.x","DOI":"10.1046\/j.1365-2222.2001.01130.x"},{"key":"62126","doi-asserted-by":"crossref","unstructured":"Pelle E, McCarthy J, Seltmann H, Huang X, Mammone T, Zouboulis CC, Maes D. Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. Journal of Investigative Dermatology. 2008; 128(5):1280-5. https:\/\/doi.org\/10.1038\/sj.jid.5701160","DOI":"10.1038\/sj.jid.5701160"},{"key":"62127","doi-asserted-by":"crossref","unstructured":"Zouboulis CC, Korge B, Akamatsu H, Xia L, Schiller S, Gollnick H, Orfanos CE. Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. Journal of investigative dermatology. 1991; 96(5):792-7. https:\/\/doi.org\/10.1111\/1523-1747.ep12471782","DOI":"10.1111\/1523-1747.ep12471782"},{"key":"62128","doi-asserted-by":"crossref","unstructured":"Dhaher SA, Jasim ZM. The adjunctive effect of desloratadine on the combined azithromycin and isotretinoin in the treatment of severe acne: Randomized clinical trial. Journal of Dermatology and Dermatologic Surgery. 2018; 22(1):21-25. https:\/\/doi.org\/10.4103\/jdds.jdds_7_18","DOI":"10.4103\/jdds.jdds_7_18"},{"key":"62129","unstructured":"Clark SM, Cunliffe WJ. Acne flare and isotretinoin-incidence and treatment. British Journal of Dermatology-Supplement-. 1995; 133:26."}],"container-title":["Open Access Macedonian Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2019.054\/2813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2019.054\/2857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T08:46:46Z","timestamp":1692521206000},"score":1,"resource":{"primary":{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/view\/oamjms.2019.054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,30]]}},"URL":"https:\/\/doi.org\/10.3889\/oamjms.2019.054","relation":{},"ISSN":["1857-9655"],"issn-type":[{"value":"1857-9655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]}}}