{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:20:01Z","timestamp":1782958801841,"version":"3.54.5"},"reference-count":18,"publisher":"Scientific Foundation Spiroski (publications)","issue":"2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy.\r\nAIM: The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population.\r\nMETHODS: We conducted a longitudinal study to evaluate the effectiveness of the low-dose therapy on the plasma homocysteine and serum folic acid level of 52 acne patients after 6-8-week treatment at University Medical Center Ho Chi Minh City, Viet Nam. Patients had moderate-severe acne with the prolonged course, and most of them had a scar.\r\nRESULTS: With a low dose of oral isotretinoin (0.37 \u00c2\u00b1 0.11 mg\/kg\/day), after 6-8-week treatment, patients dropped the severity of disease, increased the plasma homocysteine level and decreased the serum folic acid level with significant differences in comparison to those before treatment. However, these changes do not exceed the normal range.\r\nCONCLUSION: In overall, low dose isotretinoin treatment had effectiveness in decrease the severity of disease and no increasing the plasma homocysteine level as well as the serum folic acid level.<\/jats:p>","DOI":"10.3889\/oamjms.2019.094","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T08:43:08Z","timestamp":1548751388000},"page":"279-282","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam"],"prefix":"10.3889","volume":"7","author":[{"given":"Thanh Le Thai","family":"Van","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Nguyen Minh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Tran Thi Thuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Satolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Feliciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheal","family":"Tirant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Vojvodic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52292","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"62429","unstructured":"Zaenglein AL, Graber EM, Thiboutot DM. (2012). Acne vulgaris and acneiform eruption. Fitzpatrick's Dermatology in general medicine: Mc Graw Hill, 2012:897-917."},{"key":"62430","doi-asserted-by":"crossref","unstructured":"Bhate K, Williams HC. Epidemiology of acne vulgaris. British Journal of Dermatology. 2013; 168(3):474-85. https:\/\/doi.org\/10.1111\/bjd.12149 PMid:23210645","DOI":"10.1111\/bjd.12149"},{"key":"62431","doi-asserted-by":"crossref","unstructured":"Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook's textbook of dermatology. John Wiley & Sons, 2016. https:\/\/doi.org\/10.1002\/9781118441213","DOI":"10.1002\/9781118441213"},{"key":"62432","doi-asserted-by":"crossref","unstructured":"Tan JK, Bhate K. A global perspective on the epidemiology of acne. British Journal of Dermatology. 2015; 172:3-12. https:\/\/doi.org\/10.1111\/bjd.13462 PMid:25597339","DOI":"10.1111\/bjd.13462"},{"key":"62433","doi-asserted-by":"crossref","unstructured":"Charakida A, Mouser PE, Chu AC. Safety and side effects of the acne drug, oral isotretinoin. Expert opinion on drug safety. 2004; 3(2):119-29. https:\/\/doi.org\/10.1517\/14740338.3.2.119 PMid:15006718","DOI":"10.1517\/14740338.3.2.119"},{"key":"62434","doi-asserted-by":"crossref","unstructured":"Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. Jama. 2002; 288(16):2015-22. https:\/\/doi.org\/10.1001\/jama.288.16.2015","DOI":"10.1001\/jama.288.16.2015"},{"key":"62435","doi-asserted-by":"crossref","unstructured":"Den Heijer M, Rosendaal FR, Blom HJ, Gerrits WB, Bos GM. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thrombosis and Haemostasis-Stuttgart-. 1998; 80(6):874-7. https:\/\/doi.org\/10.1055\/s-0037-1615380","DOI":"10.1055\/s-0037-1615380"},{"key":"62436","doi-asserted-by":"crossref","unstructured":"Zylberstein DE, Lissner L, Bj\u00c3\u00b6rkelund C, Mehlig K, Thelle DS, Gustafson D, \u00c3\u2013stling S, Waern M, Guo X, Skoog I. Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiology of ageing. 2011; 32(3):380-6. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.02.024 PMid:19342123","DOI":"10.1016\/j.neurobiolaging.2009.02.024"},{"key":"62437","doi-asserted-by":"crossref","unstructured":"Amichai B, Shemer A, Grunwald MH. Low-dose isotretinoin in the treatment of acne vulgaris. Journal of the American Academy of Dermatology. 2006; 54(4):644-6. https:\/\/doi.org\/10.1016\/j.jaad.2005.11.1061 PMid:16546586","DOI":"10.1016\/j.jaad.2005.11.1061"},{"key":"62438","doi-asserted-by":"crossref","unstructured":"Sardana K, Garg VK, Sehgal VN, Mahajan S, Bhushan P. Efficacy of fixed low\u00e2\u20ac\u0090dose isotretinoin (20 mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):556-60. https:\/\/doi.org\/10.1111\/j.1468-3083.2008.03022.x PMid:19143903","DOI":"10.1111\/j.1468-3083.2008.03022.x"},{"key":"62439","doi-asserted-by":"crossref","unstructured":"Yap FB. Safety and efficacy of fixed\u00e2\u20ac\u0090dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia. Journal of cosmetic dermatology. 2017; 16(3):348-52. https:\/\/doi.org\/10.1111\/jocd.12268 PMid:27539948","DOI":"10.1111\/jocd.12268"},{"key":"62440","unstructured":"Ho\u00c5\u00a3oleanu C, Porojan-Iuga M, Rusu ML, Andercou A. Hyperhomocysteinemia: clinical and therapeutical involvement in venous thrombosis. Romanian journal of internal medicine= Revue roumaine de medecine interne. 2007; 45(2):159-64."},{"key":"62441","unstructured":"Kamal M, Polat M. Effect of different doses of isotretinoin treatment on the levels of serum homocysteine, vitamin B 12 and folic acid in patients with acne vulgaris: A prospective controlled study. JPMA. The Journal of the Pakistan Medical Association. 2015; 65(9):950-953. PMid:26338739"},{"key":"62442","doi-asserted-by":"crossref","unstructured":"Karadag AS, Tutal E, Ertugrul DT, Akin KO. Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non\u00e2\u20ac\u0090controlled study. International journal of dermatology. 2011; 50(12):1564-9. https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05027.x PMid:22098008","DOI":"10.1111\/j.1365-4632.2011.05027.x"},{"key":"62443","doi-asserted-by":"crossref","unstructured":"Roodsari MR, Akbari MR, Sarrafi\u00e2\u20ac\u0090Rad N, Saeedi M, Gheisari M, Kavand S. The effect of isotretinoin treatment on plasma homocysteine levels in acne vulgaris. Clinical and Experimental Dermatology: Clinical dermatology. 2010; 35(6):624-6. https:\/\/doi.org\/10.1111\/j.1365-2230.2010.03778.x PMid:20236286","DOI":"10.1111\/j.1365-2230.2010.03778.x"},{"key":"62444","doi-asserted-by":"crossref","unstructured":"Schulpis KH, Karikas GA, Georgala S, Michas T, Tsakiris S. Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. International journal of dermatology. 2001; 40(1):33-6. https:\/\/doi.org\/10.1046\/j.1365-4362.2001.00146.x PMid:11277950","DOI":"10.1046\/j.1365-4362.2001.00146.x"},{"key":"62445","doi-asserted-by":"crossref","unstructured":"G\u00c3\u00b6kalp H, Bulur I, G\u00c3\u00bcrer MA. Decreased vitamin B12 and folic Acid concentrations in acne patients after isotretinoin therapy: a controlled study. Indian journal of dermatology. 2014; 59(6):630. https:\/\/doi.org\/10.4103\/0019-5154.143533 PMid:25484410 PMCid:PMC4248518","DOI":"10.4103\/0019-5154.143533"},{"key":"62446","unstructured":"Javanbakht AM, Pour HM, Tarrahic MJ. Effects of oral isotretinoin on serum folic acid levels. Journal of drugs in dermatology: JDD. 2012; 11(9):e23-4. 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