{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:12:47Z","timestamp":1785463967960,"version":"3.56.0"},"reference-count":0,"publisher":"Scientific Foundation Spiroski (publications)","issue":"22","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>AIM: This study was carried out to investigate cytotoxic activity towards T47D, 4T1, MCF-7, HeLa, and Raji cells of alkaloid fractions of Zanthoxylum acanthopodium DC. fruits. Zanthoxylum acanthopodium DC.\r\nMETHODS: The fruit was extracted by maceration. The ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3,7, and 9 to obtained alkaloid fractions. Cytotoxic activity for fraction chloroform at pH 7 and 9 was determined with MTT assay.\r\nRESULTS: The IC50 of fraction chloroform at pH 7 and 9 was (92.67 \u00b1 1.37; 71.87 \u00b1 1.04; 159.87 \u00b1 0.63; 123.39 \u00b1 0.81; and 103.09 \u00b1 0.58 \u00b5g\/mLfor pH 7) and (451.29 \u00b1 25.48; 247.18 \u00b1 2.82; 318.46 \u00b1 5.40; 303.96 \u00b1 8.75; and 181.45 \u00b1 1.35 \u00b5g\/mL for pH 9) respectively.\r\nCONCLUSION: The results reveal that alkaloid fractions at pH 7 and 9 of Zanthoxylum acanthopodium DC. Fruits have cytotoxic activity. Our further study is to isolate and assesses anticancer activity from alkaloid compounds.<\/jats:p>","DOI":"10.3889\/oamjms.2019.495","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T18:13:59Z","timestamp":1580494439000},"page":"3745-3747","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of Cytotoxic Activity Alkaloid Fractions of Zanthoxylum acanthopodium DC. Fruits"],"prefix":"10.3889","volume":"7","author":[{"given":"Dina Maya","family":"Syari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosidah","family":"Rosidah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poppy Anjelisa Zaitun","family":"Hasibuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginda","family":"Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Satria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52292","published-online":{"date-parts":[[2019,11,14]]},"container-title":["Open Access Macedonian Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/download\/oamjms.2019.495\/4259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2019.495\/4227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T21:31:51Z","timestamp":1681939911000},"score":1,"resource":{"primary":{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/view\/oamjms.2019.495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":0,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2019,11,30]]}},"URL":"https:\/\/doi.org\/10.3889\/oamjms.2019.495","relation":{},"ISSN":["1857-9655"],"issn-type":[{"value":"1857-9655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]}}}