{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:03:25Z","timestamp":1787162605898,"version":"build-2736575974"},"reference-count":0,"publisher":"Scientific Foundation Spiroski (publications)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Access Maced J Med Sci"],"abstract":"<jats:p>BACKGROUND: Neonatal encephalopathy is a heterogeneous syndrome characterised by signs of central nervous system dysfunction in the newborn. Matrix metalloproteinase-9(MMP-9) increases the blood-brain barrier permeability, and their inhibitors can reduce its damage. MMP-9 has been implicated specifically in cerebral ischemia.\r\nAIM: To measure serum MMP-9 in neonatal hypoxic-ischemic encephalopathy and evaluate its correlation to the severity of early prediction and treatment.\r\nMETHODS: its case-control study. The serum concentration of MMP-9 was determined by ELISA in 100 hypoxic neonates and 50 healthy neonates of matched age and sex who served as controls.\r\nRESULTS: In our present study the serum MMP-9 level was significantly higher at p = 0.0001 in hypoxic-ischemic full-term newborns (176.7 \u00b1 68.7 ng\/ml)as compared to control newborn (69.4 \u00b1 34.85 ng\/ml)and it was significantly higher at p = 0.0075 in hypoxic-ischemic preterm newborn (171.2 \u00b1 132.9 ng\/ml) when compared to control newborn (72.54 \u00b1 36.74 ng\/ml),also MMP-9 was significantly higher at Sarnat stage III at p = 0.0001.\r\nCONCLUSION: Serum MMP-9 level was significantly higher in hypoxic-ischemic newborns, and significantly increased with severity, so we suggest that serum MMP-9 level is important for predicting neurological sequel and severity in neonatal encephalopathy.\r\n\u00a0<\/jats:p>","DOI":"10.3889\/oamjms.2019.618","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T12:40:02Z","timestamp":1564576802000},"page":"2114-2118","source":"Crossref","is-referenced-by-count":7,"title":["Role of Matrix Metalloproteinase-9 in Neonatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.3889","volume":"7","author":[{"given":"Mohab M.","family":"Salah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Abdelmawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally R.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-4383","authenticated-orcid":false,"given":"Rasha mahmoud","family":"Hasanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MW","family":"Abdelhameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"52292","published-online":{"date-parts":[[2019,7,31]]},"container-title":["Open Access Macedonian Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/download\/oamjms.2019.618\/3590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/oamjms.eu\/index.php\/mjms\/article\/download\/oamjms.2019.618\/3557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T17:32:37Z","timestamp":1681925557000},"score":1,"resource":{"primary":{"URL":"https:\/\/spiroski.migration.publicknowledgeproject.org\/index.php\/mjms\/article\/view\/oamjms.2019.618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":0,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.3889\/oamjms.2019.618","relation":{},"ISSN":["1857-9655"],"issn-type":[{"value":"1857-9655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]}}}