{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:12:11Z","timestamp":1769602331762,"version":"3.49.0"},"reference-count":69,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.3892\/br.2014.375","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T10:46:54Z","timestamp":1415011614000},"page":"3-8","source":"Crossref","is-referenced-by-count":35,"title":["Epigenetic modifications in human thyroid cancer"],"prefix":"10.3892","volume":"3","author":[{"given":"BITA","family":"FAAM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOHAMMAD ALI","family":"GHAFFARI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATA","family":"GHADIRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FEREIDOUN","family":"AZIZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"key20180107140759_b1-br-03-01-0003","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/0971-6866.107989","article-title":"Analysis of loss of heterozygosity effect on thyroid tumor with oxyphilia cell locus in familial non medullary thyroid carcinoma in Iranian families","volume":"18","author":"Shirazi","year":"2012","journal-title":"Indian J Hum Genet"},{"key":"key20180107140759_b2-br-03-01-0003","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/107327480601300206","article-title":"Poorly differentiated and anaplastic thyroid cancer","volume":"13","author":"Patel","year":"2006","journal-title":"Cancer Control"},{"key":"key20180107140759_b3-br-03-01-0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pharmthera.2009.03.013","article-title":"New targets and therapeutic approaches for endocrine malignancies","volume":"123","author":"Fassnacht","year":"2009","journal-title":"Pharmacol Ther"},{"key":"key20180107140759_b4-br-03-01-0003","doi-asserted-by":"crossref","first-page":"683","DOI":"10.5858\/133.5.683","article-title":"Problems and controversies in the histopathology of thyroid carcinomas of follicular cell origin","volume":"133","author":"Ghossein","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"key20180107140759_b5-br-03-01-0003","doi-asserted-by":"crossref","first-page":"264248","DOI":"10.4061\/2011\/264248","article-title":"Predominant RET germline mutations in exons 10, 11, and 16 in Iranian patients with hereditary medullary thyroid carcinoma","volume":"2011","author":"Hedayati","year":"2011","journal-title":"J Thyroid Res"},{"key":"key20180107140759_b6-br-03-01-0003","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrc1836","article-title":"Pathogenetic mechanisms in thyroid follicular-cell neoplasia","volume":"6","author":"Kondo","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"key20180107140759_b7-br-03-01-0003","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/erc.1.0978","article-title":"BRAF mutation in thyroid cancer","volume":"12","author":"Xing","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"key20180107140759_b8-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2002-021186","article-title":"Specific pattern of RAS oncogene mutations in follicular thyroid tumors","volume":"88","author":"Vasko","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b9-br-03-01-0003","first-page":"564","article-title":"Germline RET mutations in exons 10 and 11: an Iranian survey of 57 medullary thyroid carcinoma cases","volume":"61","author":"Hedayati","year":"2006","journal-title":"Med J Malaysia"},{"key":"key20180107140759_b10-br-03-01-0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/EP:13:1:03","article-title":"RET\/PTC rearrangement in thyroid tumors","volume":"13","author":"Nikiforov","year":"2002","journal-title":"Endocr Pathol"},{"key":"key20180107140759_b11-br-03-01-0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.14310\/horm.2002.1111011","article-title":"A newly detected mutation of the RET protooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A","volume":"6","author":"Bethanis","year":"2007","journal-title":"Hormones (Athens)"},{"key":"key20180107140759_b12-br-03-01-0003","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1258\/0004563011900614","article-title":"Medullary thyroid carcinoma: role of genetic testing and calcitonin measurement","volume":"38","author":"Lips","year":"2001","journal-title":"Ann Clin Biochem"},{"key":"key20180107140759_b13-br-03-01-0003","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00423-010-0682-6","article-title":"Impact of pathognomonic genetic alterations on the prognosis of papillary thyroid carcinoma. ESES vienna presentation","volume":"395","author":"Musholt","year":"2010","journal-title":"Langenbecks Arch Surg"},{"key":"key20180107140759_b14-br-03-01-0003","first-page":"1454","article-title":"High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET\/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma","volume":"63","author":"Kimura","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107140759_b15-br-03-01-0003","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1210\/jc.2003-030838","article-title":"BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas","volume":"88","author":"Nikiforova","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b16-br-03-01-0003","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"key20180107140759_b17-br-03-01-0003","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","article-title":"Epigenetics in human disease and prospects for epigenetic therapy","volume":"429","author":"Egger","year":"2004","journal-title":"Nature"},{"key":"key20180107140759_b18-br-03-01-0003","first-page":"1","article-title":"Epigenetic reprogramming in breast cancer: from new targets to new therapies","volume":"24","author":"Katz","year":"2014","journal-title":"Ann Med"},{"key":"key20180107140759_b19-br-03-01-0003","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/labinvest.2009.50","article-title":"Epigenetic silencing of TTF-1\/NKX2,1 through DNA hypermethylation and histon H3 modification in thyroid carcinoma","volume":"89","author":"Kondo","year":"2009","journal-title":"Lab invest"},{"key":"key20180107140759_b20-br-03-01-0003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-9966-33-4","article-title":"Identification of novel hypermethylated genes and demethylationg effect of vincristine in colorectal cancer","volume":"33","author":"Moon","year":"2014","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180107140759_b21-br-03-01-0003","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"key":"key20180107140759_b22-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N Engl J Med"},{"key":"key20180107140759_b23-br-03-01-0003","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.1083557","article-title":"Chromosomal instability and tumors promoted by DNA hypomethylation","volume":"300","author":"Eden","year":"2003","journal-title":"Science"},{"key":"key20180107140759_b24-br-03-01-0003","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"key20180107140759_b25-br-03-01-0003","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.96.8.4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase\/AKT pathway","volume":"96","author":"Cantley","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107140759_b26-br-03-01-0003","first-page":"RA235","article-title":"PTEN regulatory functions in tumor suppression and cell biology","volume":"10","author":"Chu","year":"2004","journal-title":"Med Sci Monit"},{"key":"key20180107140759_b27-br-03-01-0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/thy.2006.16.17","article-title":"PTEN promoter methylation in sporadic thyroid carcinomas","volume":"16","author":"Alvarez-Nu\u00f1ez","year":"2006","journal-title":"Thyroid"},{"key":"key20180107140759_b28-br-03-01-0003","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s10541-005-0151-y","article-title":"Methylation of the tumor suppressor gene RASSF1A in human tumors","volume":"70","author":"Pfeifer","year":"2005","journal-title":"Biochemistry (Mosc)"},{"key":"key20180107140759_b29-br-03-01-0003","first-page":"3698","article-title":"Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma","volume":"62","author":"Schagdarsurengin","year":"2002","journal-title":"Cancer Res"},{"key":"key20180107140759_b30-br-03-01-0003","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1158\/0008-5472.CAN-03-3242","article-title":"Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis","volume":"64","author":"Xing","year":"2004","journal-title":"Cancer Res"},{"key":"key20180107140759_b31-br-03-01-0003","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm846","article-title":"A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2","volume":"9","author":"Qi","year":"2003","journal-title":"Nat Med"},{"key":"key20180107140759_b32-br-03-01-0003","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1210\/jc.2005-0313","article-title":"Quantitative assessment of promoter methylation profiles in thyroid neoplasms","volume":"90","author":"Hoque","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b33-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1002\/ijc.22110","article-title":"Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer","volume":"119","author":"Hu","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180107140759_b34-br-03-01-0003","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/0008-5472.CAN-06-0981","article-title":"RET\/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase","volume":"67","author":"De Falco","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107140759_b35-br-03-01-0003","doi-asserted-by":"crossref","first-page":"7880","DOI":"10.1158\/0008-5472.CAN-06-0254","article-title":"Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis","volume":"66","author":"Gao","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107140759_b36-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1128\/MCB.26.6.2130-2145.2006","article-title":"Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation","volume":"26","author":"Wang","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key20180107140759_b37-br-03-01-0003","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1158\/0008-5472.CAN-05-3025","article-title":"Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer","volume":"66","author":"Zhang","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107140759_b38-br-03-01-0003","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2353\/ajpath.2006.050132","article-title":"Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma","volume":"168","author":"Zhang","year":"2006","journal-title":"Am J Pathol"},{"key":"key20180107140759_b39-br-03-01-0003","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1210\/jc.2008-1042","article-title":"Loss of Rap1GAP in papillary thyroid cancer","volume":"94","author":"Nellore","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b40-br-03-01-0003","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1128\/MCB.00155-07","article-title":"Downregulation of Rap1GAP contributes to Ras transformation","volume":"27","author":"Tsygankova","year":"2007","journal-title":"Mol Cell Biol"},{"key":"key20180107140759_b41-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/jc.2012-3566","article-title":"DNA methylation signatures identify biologically distinct thyroid cancer subtypes","volume":"98","author":"Rodr\u00edguez-Rodero","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b42-br-03-01-0003","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.onc.1207211","article-title":"Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers","volume":"23","author":"Ogasawara","year":"2004","journal-title":"Oncogene"},{"key":"key20180107140759_b43-br-03-01-0003","first-page":"2316","article-title":"Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing","volume":"63","author":"Xing","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107140759_b44-br-03-01-0003","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.gene.2012.01.077","article-title":"Association between TPO gene polymorphisms and anti-TPO level in Tehranian population: TLGS","volume":"498","author":"Faam","year":"2012","journal-title":"Gene"},{"key":"key20180107140759_b45-br-03-01-0003","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/895470","article-title":"The role of epigenetic alterations in papillary thyroid carcinogenesis","author":"Eze","year":"2011","journal-title":"J Thyroid Res 2011: 895470"},{"key":"key20180107140759_b46-br-03-01-0003","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1210\/en.2006-0927","article-title":"Gene methylation in thyroid tumorigenesis","volume":"148","author":"Xing","year":"2007","journal-title":"Endocrinology"},{"key":"key20180107140759_b47-br-03-01-0003","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1073\/pnas.0509603102","article-title":"The role of microRNA genes in papillary thyroid carcinoma","volume":"102","author":"He","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107140759_b48-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1007\/s00018-004-4273-y","article-title":"Kit as a human oncogenic tyrosine kinase","volume":"61","author":"Kitamura","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"key20180107140759_b49-br-03-01-0003","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1210\/jc.2006-0693","article-title":"A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma","volume":"91","author":"Weber","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b50-br-03-01-0003","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-5793(00)02389-9","article-title":"Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues","volume":"489","author":"Gallagher","year":"2001","journal-title":"FEBS Lett"},{"key":"key20180107140759_b51-br-03-01-0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/10507250150500603","article-title":"Activin A and activin receptors in thyroid cancer","volume":"11","author":"Schulte","year":"2001","journal-title":"Thyroid"},{"key":"key20180107140759_b52-br-03-01-0003","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1158\/1078-0432.CCR-11-0242","article-title":"MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets","volume":"17","author":"Abraham","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key20180107140759_b53-br-03-01-0003","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1089\/thy.2012.0045","article-title":"MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome","volume":"22","author":"Mian","year":"2012","journal-title":"Thyroid"},{"key":"key20180107140759_b54-br-03-01-0003","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Lagos-Quintana","year":"2001","journal-title":"Science"},{"key":"key20180107140759_b55-br-03-01-0003","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/onc.2010.416","article-title":"Upregulation of miR-21 by Ras in vivo and its role in tumor growth","volume":"30","author":"Frezzetti","year":"2011","journal-title":"Oncogene"},{"key":"key20180107140759_b56-br-03-01-0003","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1158\/0008-5472.CAN-09-2812","article-title":"Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors","volume":"70","author":"Zuo","year":"2010","journal-title":"Cancer Res"},{"key":"key20180107140759_b57-br-03-01-0003","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/cancers3021732","article-title":"DNA methylation in thyroid tumorigenesis","volume":"3","author":"Stephen","year":"2011","journal-title":"Cancers (Basel)"},{"key":"key20180107140759_b58-br-03-01-0003","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ijc.28141","article-title":"MicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development","volume":"134","author":"Zhang","year":"2014","journal-title":"Int J Cancer"},{"key":"key20180107140759_b59-br-03-01-0003","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1677\/ERC-07-0129","article-title":"MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle","volume":"14","author":"Visone","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"key20180107140759_b60-br-03-01-0003","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2007.05.022","article-title":"MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer","volume":"133","author":"Meng","year":"2007","journal-title":"Gastroenterology"},{"key":"key20180107140759_b61-br-03-01-0003","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","article-title":"MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer","volume":"27","author":"Asangani","year":"2008","journal-title":"Oncogene"},{"key":"key20180107140759_b62-br-03-01-0003","doi-asserted-by":"crossref","first-page":"e16979","DOI":"10.1371\/journal.pone.0016979","article-title":"MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells","volume":"6","author":"Sabatel","year":"2011","journal-title":"PLoS One"},{"key":"key20180107140759_b63-br-03-01-0003","doi-asserted-by":"crossref","first-page":"E546","DOI":"10.1210\/jc.2010-1594","article-title":"Thyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC)","volume":"96","author":"Jazdzewski","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107140759_b64-br-03-01-0003","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/128735","article-title":"Expression of miRNAs in papillary thyroid carcinomas is associated with BRAF mutation and clinicopathological features in Chinese patients","author":"Sun","year":"2013","journal-title":"Int J Endocrinol 2013: 128735"},{"key":"key20180107140759_b65-br-03-01-0003","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/407123","article-title":"MicroRNA role in thyroid cancer development","author":"Marini","year":"2011","journal-title":"J Thyroid Res 2011: 407123"},{"key":"key20180107140759_b66-br-03-01-0003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yexmp.2013.05.001","article-title":"Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma","volume":"95","author":"Hudson","year":"2013","journal-title":"Exp Mol Pathol"},{"key":"key20180107140759_b67-br-03-01-0003","first-page":"15","article-title":"Physiological relevance and theraeutic value of micro RNA in cancer","volume":"1","author":"Ajith","year":"2013","journal-title":"Front Pathol Genet"},{"key":"key20180107140759_b68-br-03-01-0003","doi-asserted-by":"crossref","first-page":"e80266","DOI":"10.1371\/journal.pone.0080266","article-title":"miR-127 regulates cell proliferation and senescence by targeting BCL6","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"key20180107140759_b69-br-03-01-0003","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1476-4598-6-21","article-title":"Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model","volume":"6","author":"Cahill","year":"2007","journal-title":"Mol Cancer"}],"container-title":["Biomedical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/br.2014.375\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:05:42Z","timestamp":1650510342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/br.2014.375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,11,3]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.3892\/br.2014.375"],"URL":"https:\/\/doi.org\/10.3892\/br.2014.375","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}