{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:27:51Z","timestamp":1780532871863,"version":"3.54.1"},"reference-count":24,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/br.2016.659","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T03:18:25Z","timestamp":1461035905000},"page":"673-680","source":"Crossref","is-referenced-by-count":36,"title":["Restitution analysis of alternans using dynamic pacing and its comparison with S1S2 restitution in heptanol-treated, hypokalaemic Langendorff-perfused mouse hearts"],"prefix":"10.3892","volume":"4","author":[{"given":"GARY","family":"TSE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHEUNG TING","family":"WONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VIVIAN","family":"TSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIE MING","family":"YEO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"issue":"Suppl 6","key":"key20180107141157_b1-br-0-0-659","first-page":"vi77","article-title":"Mechanisms of arrythmogenic cardiac alternans","volume":"9","author":"Wilson","year":"2007","journal-title":"Europace"},{"key":"key20180107141157_b2-br-0-0-659","doi-asserted-by":"crossref","first-page":"031904","DOI":"10.1103\/PhysRevE.67.031904","article-title":"Condition for alternans and stability of the 1:1 response pattern in a \u2018memory\u2019 model of paced cardiac dynamics","volume":"67","author":"Tolkacheva","year":"2003","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"key20180107141157_b3-br-0-0-659","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1046\/j.1540-8167.2004.03550.x","article-title":"The restitution portrait: A new method for investigating rate-dependent restitution","volume":"15","author":"Kalb","year":"2004","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key20180107141157_b4-br-0-0-659","article-title":"Mechanisms of Cardiac Arrhythmias","author":"Tse","year":"2015","journal-title":"J Arrhythmia"},{"key":"key20180107141157_b5-br-0-0-659","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00424-007-0327-y","article-title":"Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts","volume":"455","author":"Sabir","year":"2008","journal-title":"Pflugers Arch"},{"key":"key20180107141157_b6-br-0-0-659","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3892\/br.2016.577","article-title":"Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts","volume":"4","author":"Tse","year":"2016","journal-title":"Biomed Rep"},{"key":"key20180107141157_b7-br-0-0-659","doi-asserted-by":"crossref","first-page":"e0148858","DOI":"10.1371\/journal.pone.0148858","article-title":"Atrial anti-arrhythmic effects of heptanol in Langendorff-perfused mouse hearts","volume":"11","author":"Tse","year":"2016","journal-title":"PLoS One"},{"key":"key20180107141157_b8-br-0-0-659","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.1073\/pnas.171317998","article-title":"Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors","volume":"98","author":"Sun","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107141157_b9-br-0-0-659","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00424-007-0217-3","article-title":"The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts","volume":"454","author":"Sabir","year":"2007","journal-title":"Pflugers Arch"},{"key":"key20180107141157_b10-br-0-0-659","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00424-008-0508-3","article-title":"Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart","volume":"457","author":"Hothi","year":"2008","journal-title":"Pflugers Arch"},{"key":"key20180107141157_b11-br-0-0-659","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12576-011-0187-2","article-title":"Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts","volume":"62","author":"Tse","year":"2012","journal-title":"J Physiol Sci"},{"key":"key20180107141157_b12-br-0-0-659","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1748-1716.2006.01643.x","article-title":"Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart","volume":"189","author":"Killeen","year":"2007","journal-title":"Acta Physiol (Oxf)"},{"key":"key20180107141157_b13-br-0-0-659","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1540-8167.2001.00196.x","article-title":"Mechanisms for discordant alternans","volume":"12","author":"Watanabe","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key20180107141157_b14-br-0-0-659","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1540-8167.2002.01141.x","article-title":"Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias","volume":"13","author":"Banville","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key20180107141157_b15-br-0-0-659","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1161\/01.CIR.0000031334.49170.FB","article-title":"Two types of ventricular fibrillation in isolated rabbit hearts: Importance of excitability and action potential duration restitution","volume":"106","author":"Wu","year":"2002","journal-title":"Circulation"},{"key":"key20180107141157_b16-br-0-0-659","first-page":"75","article-title":"Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions","volume":"9","author":"Tse","year":"2015","journal-title":"Int J Cardiol Heart Vasc"},{"key":"key20180107141157_b17-br-0-0-659","doi-asserted-by":"crossref","first-page":"H210","DOI":"10.1152\/ajpheart.00695.2009","article-title":"Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity","volume":"298","author":"Osadchii","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20180107141157_b18-br-0-0-659","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0735-1097(89)90490-7","article-title":"Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: Role of the transient outward current","volume":"14","author":"Litovsky","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"key20180107141157_b19-br-0-0-659","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/expphysiol.2012.065219","article-title":"Effects of ventricular pacing protocol on electrical restitution assessments in guinea-pig heart","volume":"97","author":"Osadchii","year":"2012","journal-title":"Exp Physiol"},{"key":"key20180107141157_b20-br-0-0-659","first-page":"H1635","article-title":"Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation","volume":"275","author":"Koller","year":"1998","journal-title":"Am J Physiol"},{"key":"key20180107141157_b21-br-0-0-659","doi-asserted-by":"crossref","first-page":"e462","DOI":"10.1161\/CIRCULATIONAHA.105.597310","article-title":"Letter regarding article by Koller et al, \u2018Altered dynamics of action potential restitution and alternans in humans with structural heart disease\u2019","volume":"113","author":"Yue","year":"2006","journal-title":"Circulation"},{"key":"key20180107141157_b22-br-0-0-659","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.0954-6820.1971.tb07463.x","article-title":"Coronary circulation during pacing-induced tachycardia","volume":"190","author":"Holmberg","year":"1971","journal-title":"Acta Med Scand"},{"key":"key20180107141157_b23-br-0-0-659","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/01.CIR.46.1.74","article-title":"Effect of pacing-induced tachycardia and myocardial ischemia on ventricular pressure-velocity relationships in man","volume":"46","author":"Graber","year":"1972","journal-title":"Circulation"},{"key":"key20180107141157_b24-br-0-0-659","article-title":"Cardiac dynamics: Alternans and arrhythmogenesis","author":"Tse","journal-title":"Arrhythmia"}],"container-title":["Biomedical Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/br.2016.659\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T09:18:06Z","timestamp":1515316686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/br.2016.659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,19]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/br.2016.659"],"URL":"https:\/\/doi.org\/10.3892\/br.2016.659","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]}}}