{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:01:49Z","timestamp":1790676109016,"version":"4.1.0"},"reference-count":43,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.3892\/br.2017.955","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T05:58:10Z","timestamp":1501135090000},"page":"209-213","source":"Crossref","is-referenced-by-count":18,"title":["The conceptual advances of carcinogenic sequence model in high-grade serous ovarian cancer"],"prefix":"10.3892","volume":"7","author":[{"given":"Hiroshi","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Niiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"key20180107142019_b1-br-0-0-955","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/pin.12419","article-title":"Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer","volume":"66","author":"Nishida","year":"2016","journal-title":"Pathol Int"},{"key":"key20180107142019_b2-br-0-0-955","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/jog.12550","article-title":"Precursors of ovarian cancer in the fallopian tube: Serous tubal intraepithelial carcinoma - an update","volume":"41","author":"Zeppernick","year":"2015","journal-title":"J Obstet Gynaecol Res"},{"key":"key20180107142019_b3-br-0-0-955","first-page":"433","article-title":"Morphologic changes of fallopian tubal epithelium in ovarian serous tumors","volume":"41","author":"Wen","year":"2012","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"key20180107142019_b4-br-0-0-955","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ygyno.2013.09.018","article-title":"Secretory cell expansion with aging: Risk for pelvic serous carcinogenesis","volume":"131","author":"Li","year":"2013","journal-title":"Gynecol Oncol"},{"key":"key20180107142019_b5-br-0-0-955","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/path.2739","article-title":"Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube","volume":"222","author":"Chen","year":"2010","journal-title":"J Pathol"},{"key":"key20180107142019_b6-br-0-0-955","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1200\/JCO.2008.16.4814","article-title":"Serous tubal intraepithelial carcinoma: Its potential role in primary peritoneal serous carcinoma and serous cancer prevention","volume":"26","author":"Carlson","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20180107142019_b7-br-0-0-955","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.pgp.0000101082.35393.84","article-title":"Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers","volume":"23","author":"Carcangiu","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"key20180107142019_b8-br-0-0-955","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1525-1438.2006.00287.x","article-title":"Prophylactic salpingo-oophorectomy in 51 women with familial breast-ovarian cancer: Importance of fallopian tube dysplasia","volume":"16","author":"Leunen","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"key20180107142019_b9-br-0-0-955","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"key20180107142019_b10-br-0-0-955","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/GCO.0b013e328011a21f","article-title":"The distal fallopian tube: A new model for pelvic serous carcinogenesis","volume":"19","author":"Crum","year":"2007","journal-title":"Curr Opin Obstet Gynecol"},{"key":"key20180107142019_b11-br-0-0-955","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2559.2007.02938.x","article-title":"Tubal and ovarian pathways to pelvic epithelial cancer: A pathological perspective","volume":"53","author":"Jarboe","year":"2008","journal-title":"Histopathology"},{"key":"key20180107142019_b12-br-0-0-955","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/0377-4929.191789","article-title":"Secretory cell outgrowths, p53 signatures, and serous tubal intraepithelial carcinoma in the fallopian tubes of patients with sporadic pelvic serous carcinoma","volume":"59","author":"Mittal","year":"2016","journal-title":"Indian J Pathol Microbiol"},{"key":"key20180107142019_b13-br-0-0-955","first-page":"848","article-title":"Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis","volume":"7","author":"Li","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"key20180107142019_b14-br-0-0-955","first-page":"881","article-title":"Role of endosalpinx in the oviductal environment","volume":"41","author":"Ebihara","year":"1989","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"key20180107142019_b15-br-0-0-955","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2559.2001.1163c.x","article-title":"Cell cycle-related proteins p21 and bcl-2: Markers of differentiation in the human fallopian tube","volume":"38","author":"Piek","year":"2001","journal-title":"Histopathology"},{"key":"key20180107142019_b16-br-0-0-955","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.4649","article-title":"In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells","volume":"238","author":"Yamamoto","year":"2016","journal-title":"J Pathol"},{"key":"key20180107142019_b17-br-0-0-955","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/path.4807","article-title":"Haemoglobin in pelvic fluid rescues Fallopian tube epithelial cells from reactive oxygen species stress and apoptosis","volume":"240","author":"Huang","year":"2016","journal-title":"J Pathol"},{"key":"key20180107142019_b18-br-0-0-955","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/PGP.0b013e31823b8831","article-title":"Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma","volume":"31","author":"Vang","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"key20180107142019_b19-br-0-0-955","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1080\/14737140.2016.1247699","article-title":"Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management","volume":"16","author":"Weinberger","year":"2016","journal-title":"Expert Rev Anticancer Ther"},{"key":"key20180107142019_b20-br-0-0-955","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/1471-0528.14543","article-title":"Serous tubal intraepithelial carcinomas associated with high-grade serous ovarian carcinomas: A systematic review","volume":"124","author":"Chen","year":"2017","journal-title":"BJOG"},{"key":"key20180107142019_b21-br-0-0-955","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/IGC.0000000000000920","article-title":"Serous tubal intraepithelial carcinoma associated with extraovarian metastases","volume":"27","author":"Schneider","year":"2017","journal-title":"Int J Gynecol Cancer"},{"key":"key20180107142019_b22-br-0-0-955","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00428-016-1928-7","article-title":"Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development","volume":"468","author":"Malmberg","year":"2016","journal-title":"Virchows Arch"},{"key":"key20180107142019_b23-br-0-0-955","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jmig.2016.12.007","article-title":"Role of fallopian tubes in the development of ovarian cancer","volume":"24","author":"Corzo","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"key":"key20180107142019_b24-br-0-0-955","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1158\/2159-8290.CD-16-0607","article-title":"Genomics of ovarian cancer progression reveals diverse metastatic trajectories including intraepithelial metastasis to the fallopian tube","volume":"6","author":"Eckert","year":"2016","journal-title":"Cancer Discov"},{"key":"key20180107142019_b25-br-0-0-955","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/path.4417","article-title":"The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium","volume":"234","author":"Ning","year":"2014","journal-title":"J Pathol"},{"key":"key20180107142019_b26-br-0-0-955","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1093\/humrep\/13.11.3114","article-title":"Induction of a differentiated ciliated cell phenotype in primary cultures of Fallopian tube epithelium","volume":"13","author":"Comer","year":"1998","journal-title":"Hum Reprod"},{"key":"key20180107142019_b27-br-0-0-955","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.humpath.2015.03.017","article-title":"PAX8 expression in ovarian surface epithelial cells","volume":"46","author":"Adler","year":"2015","journal-title":"Hum Pathol"},{"key":"key20180107142019_b28-br-0-0-955","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/PGP.0000000000000120","article-title":"Two types of ovarian cortical inclusion cysts: Proposed origin and possible role in ovarian serous carcinogenesis","volume":"34","author":"Banet","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"key20180107142019_b29-br-0-0-955","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ygyno.2011.05.021","article-title":"Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas","volume":"123","author":"Karst","year":"2011","journal-title":"Gynecol Oncol"},{"key":"key20180107142019_b30-br-0-0-955","doi-asserted-by":"crossref","first-page":"19214","DOI":"10.18632\/oncotarget.8468","article-title":"Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium","volume":"7","author":"Bajwa","year":"2016","journal-title":"Oncotarget"},{"key":"key20180107142019_b31-br-0-0-955","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/modpathol.2014.89","article-title":"Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma","volume":"28","author":"Chui","year":"2015","journal-title":"Mod Pathol"},{"key":"key20180107142019_b32-br-0-0-955","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/modpathol.2016.101","article-title":"CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: Further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma","volume":"29","author":"Kuhn","year":"2016","journal-title":"Mod Pathol"},{"key":"key20180107142019_b33-br-0-0-955","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ygyno.2015.07.100","article-title":"Stathmin 1 and p16 (INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma","volume":"139","author":"Novak","year":"2015","journal-title":"Gynecol Oncol"},{"key":"key20180107142019_b34-br-0-0-955","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1097\/PAS.0b013e31825ec07a","article-title":"The diagnostic and biological implications of laminin expression in serous tubal intraepithelial carcinoma","volume":"36","author":"Kuhn","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"key20180107142019_b35-br-0-0-955","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/PAS.0b013e3181dcede7","article-title":"Shortened telomeres in serous tubal intraepithelial carcinoma: An early event in ovarian high-grade serous carcinogenesis","volume":"34","author":"Kuhn","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"key20180107142019_b36-br-0-0-955","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/modpathol.2010.60","article-title":"Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase","volume":"23","author":"Sehdev","year":"2010","journal-title":"Mod Pathol"},{"key":"key20180107142019_b37-br-0-0-955","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0b013e3181be5d72","article-title":"HMGA2: A potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes","volume":"34","author":"Wei","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"key20180107142019_b38-br-0-0-955","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(71)92335-X","article-title":"Incessant ovulation - -a factor in ovarian neoplasia?","volume":"2","author":"Fathalla","year":"1971","journal-title":"Lancet"},{"key":"key20180107142019_b39-br-0-0-955","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/CBM-2011-0167","article-title":"Molecular pathogenesis of endometrial and ovarian cancer","volume":"9","author":"Merritt","year":"2010","journal-title":"Cancer Biomark"},{"key":"key20180107142019_b40-br-0-0-955","doi-asserted-by":"crossref","first-page":"x16","DOI":"10.1093\/annonc\/mdt463","article-title":"Origin and molecular pathogenesis of ovarian high-grade serous carcinoma","volume":"24","author":"Kurman","year":"2013","journal-title":"Ann Oncol"},{"key":"key20180107142019_b41-br-0-0-955","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/modpathol.2016.238","article-title":"Serous tubal intraepithelial neoplasia: The concept and its application","volume":"30","author":"Meserve","year":"2017","journal-title":"Mod Pathol"},{"key":"key20180107142019_b42-br-0-0-955","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/PAS.0000000000000353","article-title":"Incidental nonuterine high-grade serous carcinomas arise in the fallopian tube in most cases: Further evidence for the tubal origin of high-grade serous carcinomas","volume":"39","author":"Gilks","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"key20180107142019_b43-br-0-0-955","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/path.4263","article-title":"Through the glass darkly: Intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer","volume":"231","author":"Crum","year":"2013","journal-title":"J Pathol"}],"container-title":["Biomedical Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T13:03:15Z","timestamp":1602594195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/br.2017.955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7,27]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.3892\/br.2017.955"],"URL":"https:\/\/doi.org\/10.3892\/br.2017.955","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}