{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:01:16Z","timestamp":1791576076614,"version":"4.3.4"},"reference-count":123,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2023.1704","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T09:45:13Z","timestamp":1701942313000},"source":"Crossref","is-referenced-by-count":7,"title":["Effect of animal venom toxins on the main links of the homeostasis of mammals (Review)"],"prefix":"10.3892","volume":"20","author":[{"given":"Ruzhena","family":"Matkivska","sequence":"first","affiliation":[{"name":"Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University, Kyiv 03680, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inha","family":"Samborska","sequence":"additional","affiliation":[{"name":"Department of Biological and General Chemistry, National Pirogov Memorial Medical University, Vinnytsya 21018, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Maievskyi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Educational and Scientific Center \u2018Institute of Biology and Medicine\u2019 of Taras Shevchenko National University of Kyiv, Kyiv 03127, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"308","key":"key20240126100521_b1-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00308","article-title":"Neuro-immune circuits regulate immune responses in tissues and organ homeostasis","volume":"11","author":"Jakob","year":"2020","journal-title":"Front Immunol"},{"key":"key20240126100521_b2-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1146\/annurev-immunol-061020-053734","article-title":"Tissue homeostasis and inflammation","volume":"39","author":"Meizlish","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"key20240126100521_b3-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.it.2017.08.009","article-title":"Control of immune cell homeostasis and function by lncRNAs","volume":"39","author":"Mowel","year":"2018","journal-title":"Trends Immunol"},{"key":"key20240126100521_b4-BR-20-2-01704","doi-asserted-by":"crossref","first-page":"29","DOI":"10.47577\/technium.v2i7.1669","article-title":"The Human organism is a biophysical-biopsychological system","volume":"2","author":"Vincze","year":"2018","journal-title":"Technium"},{"issue":"9643","key":"key20240126100521_b5-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179643","article-title":"Bleeding and thrombosis: Insights into pathophysiology of Bothrops venom-related hemostasis disorders","volume":"22","author":"Larr\u00e9ch\u00e9","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"e1900324","key":"key20240126100521_b6-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201900324","article-title":"Deadly proteomes: A practical guide to proteotranscriptomics of animal venoms","volume":"20","author":"Walker","year":"2020","journal-title":"Proteomics"},{"key":"key20240126100521_b7-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.idc.2018.10.001","article-title":"Venomous bites, stings, and poisoning: An update","volume":"33","author":"Warrell","year":"2019","journal-title":"Infect Dis Clin North Am"},{"key":"key20240126100521_b8-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling-from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J"},{"key":"key20240126100521_b9-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20170092","article-title":"ER homeostasis and autophagy","volume":"61","author":"Smith","year":"2017","journal-title":"Essays Biochem"},{"issue":"73","key":"key20240126100521_b10-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10020073","article-title":"Pharmacokinetics of snake venom","volume":"10","author":"Sanhajariya","year":"2018","journal-title":"Toxins (Basel)"},{"issue":"46","key":"key20240126100521_b11-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1186\/s40409-015-0046-3","article-title":"Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes","volume":"21","author":"Casella-Martins","year":"2015","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"issue":"716508","key":"key20240126100521_b12-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.716508","article-title":"Editorial: Venoms and toxins: At the crossroads of basic, applied and clinical immunology","volume":"12","author":"Pucca","year":"2021","journal-title":"Front Immunol"},{"issue":"344","key":"key20240126100521_b13-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14050344","article-title":"Biological effects of animal venoms on the human immune system","volume":"14","author":"Avalo","year":"2022","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b14-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.toxicon.2020.12.018","article-title":"Immunomodulatory properties of molecules from animal venoms","volume":"191","author":"Minutti-Zanella","year":"2021","journal-title":"Toxicon"},{"key":"key20240126100521_b15-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.toxicon.2016.09.021","article-title":"Impact of scorpion venom as an acute stressor on the neuroendocrine-immunological network","volume":"122","author":"Santhosh","year":"2016","journal-title":"Toxicon"},{"key":"key20240126100521_b16-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1089\/wound.2012.0435","article-title":"Innate and adaptive immune responses in wound epithelialization","volume":"3","author":"Strbo","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"e10346","key":"key20240126100521_b17-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10346","article-title":"Therapeutic potential of nanoceria pretreatment in preventing the development of urological chronic pelvic pain syndrome: Immunomodulation via reactive oxygen species scavenging and SerpinB2 downregulation","volume":"8","author":"Lien","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"key20240126100521_b18-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.apsb.2022.09.019","article-title":"ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance Anti-Epileptic therapy","volume":"13","author":"Zhou","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"key20240126100521_b19-BR-20-2-01704","first-page":"133","article-title":"Unraveling Immune-Epithelial interactions in skin homeostasis and injury","volume":"93","author":"Mansfield","year":"2020","journal-title":"Yale J Biol Med"},{"issue":"8790","key":"key20240126100521_b20-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228790","article-title":"The immune functions of keratinocytes in skin wound healing","volume":"21","author":"Piipponen","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20240126100521_b21-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.clinthera.2020.03.008","article-title":"Stress-Induced interaction of skin immune cells, hormones, and neurotransmitters","volume":"42","author":"Pondeljak","year":"2020","journal-title":"Clin Ther"},{"key":"key20240126100521_b22-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.it.2018.02.004","article-title":"Cutaneous barriers and skin immunity: Differentiating a connected network","volume":"39","author":"Eyerich","year":"2018","journal-title":"Trends Immunol"},{"issue":"781","key":"key20240126100521_b23-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37435-4","article-title":"L-amino acid oxidase from Bothrops atrox snake venom triggers autophagy, apoptosis and necrosis in normal human keratinocytes","volume":"9","author":"Costal-Oliveira","year":"2019","journal-title":"Sci Rep"},{"issue":"2156587217751796","key":"key20240126100521_b24-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1177\/2156587217751796","article-title":"Scorpion venom causes apoptosis by increasing reactive oxygen species and cell cycle arrest in MDA-MB-231 and HCT-8 cancer cell lines","volume":"23","author":"Al-Asmari","year":"2018","journal-title":"J Evid Based Integr Med"},{"issue":"304","key":"key20240126100521_b25-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8100304","article-title":"A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): Novel perspectives on the pathophysiology of envenoming","volume":"8","author":"Guti\u00e9rrez","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"631","key":"key20240126100521_b26-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12100631","article-title":"Antigenic and substrate preference differences between scorpion and spider dermonecrotic toxins, a comparative investigation","volume":"12","author":"Ben Yekhlef","year":"2020","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b27-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/15563650.2019.1578367","article-title":"The kiss of (cell) death: Can venom-induced immune response contribute to dermal necrosis following arthropod envenomations?","volume":"57","author":"Dunbar","year":"2019","journal-title":"Clin Toxicol (Phila)"},{"key":"key20240126100521_b28-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/jdv.13274","article-title":"Cutaneous loxoscelism due to Loxosceles rufescens","volume":"30","author":"Morales-Moreno","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key20240126100521_b29-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.toxicon.2017.04.007","article-title":"Distribution and medical aspects of Loxosceles rufescens, one of the most invasive spiders of the world (Araneae: Sicariidae)","volume":"132","author":"Nentwig","year":"2017","journal-title":"Toxicon"},{"issue":"1907","key":"key20240126100521_b30-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01907","article-title":"Antigen presentation by vascular cells","volume":"8","author":"Pober","year":"2017","journal-title":"Front Immunol"},{"key":"key20240126100521_b31-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ajpath.2019.11.004","article-title":"Endothelial cell calcium signaling during barrier function and inflammation","volume":"190","author":"Dalal","year":"2020","journal-title":"Am J Pathol"},{"key":"key20240126100521_b32-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.ijbiomac.2019.05.019","article-title":"Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells","volume":"134","author":"De Andrade","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"key20240126100521_b33-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/cmi.12580","article-title":"Macrophages: Sentinels and regulators of the immune system","volume":"18","author":"Franken","year":"2016","journal-title":"Cell Microbiol"},{"issue":"7873257","key":"key20240126100521_b34-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7873257","article-title":"Crotoxin isolated from Crotalus durissus terrificus venom modulates the functional activity of dendritic cells via formyl peptide receptors","volume":"2018","author":"Freitas","year":"2018","journal-title":"J Immunol Res"},{"issue":"e93741","key":"key20240126100521_b35-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093741","article-title":"Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2 from snake venom","volume":"9","author":"Leiguez","year":"2014","journal-title":"PLoS One"},{"key":"key20240126100521_b36-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbagen.2013.10.031","article-title":"Membrane-modifying properties of crotamine, a small peptide-toxin from Crotalus durissus terifficus venom","volume":"1840","author":"Sieber","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key20240126100521_b37-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cbi.2017.12.022","article-title":"Evaluation of pro-inflammatory events induced by Bothrops alternatus snake venom","volume":"281","author":"Echeverr\u00eda","year":"2018","journal-title":"Chem Biol Interact"},{"key":"key20240126100521_b38-BR-20-2-01704","first-page":"430","article-title":"Effect of Bothrops alternatus snake venom on macrophage phagocytosis and superoxide production: Participation of protein kinase C","volume":"17","author":"Setubal","year":"2011","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"issue":"9603271211072872","key":"key20240126100521_b39-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211072872","article-title":"Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study","volume":"41","author":"Darkaoui","year":"2022","journal-title":"Hum Exp Toxicol"},{"key":"key20240126100521_b40-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.toxicon.2015.09.029","article-title":"Induction of IL-12 from human monocytes after stimulation with Androctonus crassicauda scorpion venom","volume":"106","author":"Saadi","year":"2015","journal-title":"Toxicon"},{"key":"key20240126100521_b41-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s10753-018-0731-9","article-title":"Involvement of alveolar macrophages and neutrophils in acute lung injury after scorpion envenomation: New pharmacological targets","volume":"41","author":"Saidi","year":"2018","journal-title":"Inflammation"},{"key":"key20240126100521_b42-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00011-015-0876-z","article-title":"TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom","volume":"64","author":"Ait-Lounis","year":"2015","journal-title":"Inflamm Res"},{"key":"key20240126100521_b43-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.toxicon.2017.01.007","article-title":"Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells","volume":"127","author":"Corzo","year":"2017","journal-title":"Toxicon"},{"key":"key20240126100521_b44-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.biochi.2015.04.010","article-title":"Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages","volume":"115","author":"Pucca","year":"2015","journal-title":"Biochimie"},{"key":"key20240126100521_b45-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/JLB.MA1118-463R","article-title":"Lectin isolated from Bothrops jararacussu venom induces IL-10 release by TCD4+cells and TNF-\u03b1 release by monocytes and natural killer cells","volume":"106","author":"Pires","year":"2019","journal-title":"J Leukoc Biol"},{"key":"key20240126100521_b46-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.2174\/1568026619666190809100319","article-title":"Bothrops alternatus snake venom induces cytokine expression and oxidative stress on renal function","volume":"19","author":"J\u00fanior","year":"2019","journal-title":"Curr Top Med Chem"},{"issue":"125","key":"key20240126100521_b47-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9040125","article-title":"Phospholipase D from Loxosceles laeta spider venom induces IL-6, IL-8, CXCL1\/GRO-\u03b1, and CCL2\/MCP-1 production in human skin fibroblasts and stimulates monocytes migration","volume":"9","author":"Rojas","year":"2017","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b48-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1684\/mst.2017.0688","article-title":"Severe scorpion envenomation: Pathophysiology and the role of inflammation in multiple organ failure","volume":"27","author":"Bahloul","year":"2017","journal-title":"Med Sante Trop"},{"key":"key20240126100521_b49-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00249-018-1323-1","article-title":"Differential effect of Androctonus australis hector venom components on macrophage KV channels: Electrophysiological characterization","volume":"48","author":"Khemili","year":"2019","journal-title":"Eur Biophys J"},{"issue":"661082","key":"key20240126100521_b50-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.661082","article-title":"Immunological responses to envenomation","volume":"12","author":"Ryan","year":"2021","journal-title":"Front Immunol"},{"key":"key20240126100521_b51-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1189\/jlb.1212619","article-title":"Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: Correlation with transcriptome profiling of neutrophil precursors","volume":"94","author":"R\u00f8rvig","year":"2013","journal-title":"J Leukoc Biol"},{"issue":"e1004651","key":"key20240126100521_b52-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: Between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog"},{"key":"key20240126100521_b53-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","article-title":"Leukocyte migration into inflamed tissues","volume":"41","author":"Nourshargh","year":"2014","journal-title":"Immunity"},{"key":"key20240126100521_b54-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.toxicon.2013.09.019","article-title":"Effect of Bothrops bilineata snake venom on neutrophil function","volume":"76","author":"Setubal Sda","year":"2013","journal-title":"Toxicon"},{"issue":"508","key":"key20240126100521_b55-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: Facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front Immunol"},{"key":"key20240126100521_b56-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.toxicon.2020.09.006","article-title":"Polymorphonuclear neutrophil leukocytes in snakebite envenoming","volume":"187","author":"Zuliani","year":"2020","journal-title":"Toxicon"},{"key":"key20240126100521_b57-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s10753-019-01105-y","article-title":"Involvement of toll-like receptor 4 in neutrophil-mediated inflammation, oxidative stress and tissue damage induced by scorpion venom","volume":"43","author":"Khemili","year":"2020","journal-title":"Inflammation"},{"issue":"e88174","key":"key20240126100521_b58-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088174","article-title":"TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce Macrophage-Derived inflammatory mediators","volume":"9","author":"Zoccal","year":"2014","journal-title":"PLoS One"},{"key":"key20240126100521_b59-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.toxicon.2016.04.042","article-title":"The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom","volume":"118","author":"Moreira","year":"2016","journal-title":"Toxicon"},{"key":"key20240126100521_b60-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.toxicon.2018.06.066","article-title":"LTB4 and PGE2 modulate the release of MIP-1\u03b1 and IL-1\u03b2 by cells stimulated with Bothrops snake venoms","volume":"150","author":"Zoccal","year":"2018","journal-title":"Toxicon"},{"key":"key20240126100521_b61-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1073\/pnas.1221476110","article-title":"Role of the inflammasome in defense against venoms","volume":"110","author":"Palm","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10760","key":"key20240126100521_b62-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10760","article-title":"Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality","volume":"7","author":"Zoccal","year":"2016","journal-title":"Nat Commun"},{"issue":"1873","key":"key20240126100521_b63-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01873","article-title":"The Role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: The hunt for new therapeutic targets","volume":"9","author":"Thangam","year":"2018","journal-title":"Front Immunol"},{"key":"key20240126100521_b64-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.alit.2015.09.002","article-title":"Mast cells and IgE in defense against venoms: Possible \u2018good side\u2019 of allergy?","volume":"65","author":"Galli","year":"2016","journal-title":"Allergol Int"},{"key":"key20240126100521_b65-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.aller.2015.05.001","article-title":"Histamine, histamine intoxication and intolerance","volume":"43","author":"Kovacova-Hanuskova","year":"2015","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"620","key":"key20240126100521_b66-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00620","article-title":"Mast cell: A multi-functional master cell","volume":"6","author":"Krystel-Whittemore","year":"2016","journal-title":"Front Immunol"},{"key":"key20240126100521_b67-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.intimp.2013.02.023","article-title":"Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response","volume":"15","author":"Menaldo","year":"2013","journal-title":"Int Immunopharmacol"},{"issue":"569","key":"key20240126100521_b68-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00569","article-title":"Mast cell mediators: Their differential release and the secretory pathways involved","volume":"5","author":"Moon","year":"2014","journal-title":"Front Immunol"},{"key":"key20240126100521_b69-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jaip.2015.09.016","article-title":"Venom allergy","volume":"4","author":"Stitt","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"e2326","key":"key20240126100521_b70-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002326","article-title":"Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation","volume":"7","author":"Stone","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key20240126100521_b71-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.molimm.2014.06.020","article-title":"Animal venoms\/toxins and the complement system","volume":"61","author":"Tambourgi","year":"2014","journal-title":"Mol Immunol"},{"issue":"108000","key":"key20240126100521_b72-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2021.108000","article-title":"Study of lipid heterogeneity on bilayer membranes using molecular dynamics simulations","volume":"108","author":"Kumar","year":"2021","journal-title":"J Mol Graph Model"},{"key":"key20240126100521_b73-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plipres.2014.01.001","article-title":"Lipid requirements for entry of protein toxins into cells","volume":"54","author":"Sandvig","year":"2014","journal-title":"Prog Lipid Res"},{"issue":"114096","key":"key20240126100521_b74-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114096","article-title":"Animal toxins-Nature's evolutionary-refined toolkit for basic research and drug discovery","volume":"181","author":"Herzig","year":"2020","journal-title":"Biochem Pharmacol"},{"issue":"811365","key":"key20240126100521_b75-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.811365","article-title":"Structural and functional diversity of animal toxins interacting with GPCRs","volume":"9","author":"Van Baelen","year":"2022","journal-title":"Front Mol Biosci"},{"issue":"3373","key":"key20240126100521_b76-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113373","article-title":"Venom-derived neurotoxins targeting nicotinic acetylcholine receptors","volume":"26","author":"Bekbossynova","year":"2021","journal-title":"Molecules"},{"key":"key20240126100521_b77-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neuropharm.2017.07.036","article-title":"Modelling the interactions between animal venom peptides and membrane proteins","volume":"127","author":"Hung","year":"2017","journal-title":"Neuropharmacology"},{"key":"key20240126100521_b78-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1002\/1873-3468.13530","article-title":"Scorpion toxins interact with nicotinic acetylcholine receptors","volume":"593","author":"Kasheverov","year":"2019","journal-title":"FEBS Lett"},{"key":"key20240126100521_b79-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.tem.2015.06.002","article-title":"Cardiac contraction-induced GLUT4 translocation requires dual signaling input","volume":"26","author":"Luiken","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"key20240126100521_b80-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.neuropharm.2019.04.013","article-title":"Scorpion venom increases acetylcholine release by prolonging the duration of somatic nerve action potentials","volume":"153","author":"O Colla\u00e7o","year":"2019","journal-title":"Neuropharmacology"},{"issue":"060401","key":"key20240126100521_b81-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.102.060401","article-title":"Regulation of membrane proteins through local heterogeneity in lipid bilayer thickness","volume":"102","author":"Shrestha","year":"2020","journal-title":"Phys Rev E"},{"key":"key20240126100521_b82-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ceb.2018.04.013","article-title":"Cellular mechanisms of physicochemical membrane homeostasis","volume":"53","author":"Ernst","year":"2018","journal-title":"Curr Opin Cell Biol"},{"key":"key20240126100521_b83-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.tibs.2014.09.002","article-title":"Membrane pore formation at protein-lipid interfaces","volume":"39","author":"Gilbert","year":"2014","journal-title":"Trends Biochem Sci"},{"issue":"147","key":"key20240126100521_b84-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13020147","article-title":"Cell-penetrating peptides derived from animal venoms and toxins","volume":"13","author":"R\u00e1dis-Baptista","year":"2021","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b85-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1021\/nn4057269","article-title":"Cell-penetrating peptides: Design, synthesis, and applications","volume":"8","author":"Copolovici","year":"2014","journal-title":"ACS Nano"},{"key":"key20240126100521_b86-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrmicro.2015.3","article-title":"Pore-forming toxins: Ancient, but never really out of fashion","volume":"14","author":"Dal Peraro","year":"2016","journal-title":"Nat Rev Microbiol"},{"issue":"1929","key":"key20240126100521_b87-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111929","article-title":"Cell-penetrating peptides: Design strategies beyond primary structure and amphipathicity","volume":"22","author":"Kalafatovic","year":"2017","journal-title":"Molecules"},{"issue":"675985","key":"key20240126100521_b88-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/675985","article-title":"State of the art in the studies on crotamine, a cell penetrating peptide from South American rattlesnake","volume":"2014","author":"Kerkis","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20240126100521_b89-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.cell.2019.07.014","article-title":"A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain","volume":"178","author":"Lin King","year":"2019","journal-title":"Cell"},{"key":"key20240126100521_b90-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ijbiomac.2017.12.101","article-title":"An overview of the immune modulating effects of enzymatic toxins from snake venoms","volume":"109","author":"Burin","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"key20240126100521_b91-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1007\/s00253-016-7610-9","article-title":"Snake venom toxins: Toxicity and medicinal applications","volume":"100","author":"Chan","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"key":"key20240126100521_b92-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.toxlet.2018.02.004","article-title":"Synergistic strategies of predominant toxins in snake venoms","volume":"287","author":"Xiong","year":"2018","journal-title":"Toxicol Lett"},{"issue":"218","key":"key20240126100521_b93-BR-20-2-01704","article-title":"Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis","volume":"7","author":"Ferraz","year":"2019","journal-title":"Front Ecol Evol"},{"key":"key20240126100521_b94-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.toxicon.2018.10.306","article-title":"Crotoxin from Crotalus durissus terrificus venom: In vitro cytotoxic activity of a heterodimeric phospholipase A2 on human cancer-derived cell lines","volume":"156","author":"Muller","year":"2018","journal-title":"Toxicon"},{"issue":"1775","key":"key20240126100521_b95-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24091775","article-title":"How melittin inserts into cell membrane: Conformational changes, Inter-Peptide cooperation, and disturbance on the membrane","volume":"24","author":"Hong","year":"2019","journal-title":"Molecules"},{"key":"key20240126100521_b96-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cois.2018.10.001","article-title":"Insect toxins-selective pharmacological tools and drug\/chemical leads","volume":"30","author":"Kachel","year":"2018","journal-title":"Curr Opin Insect Sci"},{"issue":"4941","key":"key20240126100521_b97-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164941","article-title":"Bee venom: From venom to drug","volume":"26","author":"Khalil","year":"2021","journal-title":"Molecules"},{"key":"key20240126100521_b98-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/092986652507180813110453","article-title":"Advances in usage of venom proteins as diagnostics and therapeutic mediators","volume":"25","author":"Khan","year":"2018","journal-title":"Protein Pept Lett"},{"issue":"191","key":"key20240126100521_b99-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13030191","article-title":"Bee venom and its sub-components: Characterization, pharmacology, and therapeutics","volume":"13","author":"Kim","year":"2021","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b100-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.canlet.2017.05.010","article-title":"Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy","volume":"402","author":"Rady","year":"2017","journal-title":"Cancer Lett"},{"issue":"2997","key":"key20240126100521_b101-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24162997","article-title":"Bee venom: Overview of main compounds and bioactivities for therapeutic interests","volume":"24","author":"Wehbe","year":"2019","journal-title":"Molecules"},{"key":"key20240126100521_b102-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10989-018-9721-x","article-title":"Scorpion venom-toxins that aid in drug development: A review","volume":"25","author":"Ghosh","year":"2019","journal-title":"Int J Pept Res Ther"},{"key":"key20240126100521_b103-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-3-642-41588-3_10","article-title":"Animal toxins influence voltage-gated sodium channel function","volume":"221","author":"Gilchrist","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"key20240126100521_b104-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neulet.2017.10.050","article-title":"Labelled animal toxins as selective molecular markers of ion channels: Applications in neurobiology and beyond","volume":"679","author":"Kuzmenkov","year":"2018","journal-title":"Neurosci Lett"},{"issue":"e00873","key":"key20240126100521_b105-BR-20-2-01704","article-title":"Ion channels: The scorpion toxin and the potassium channel","volume":"2","author":"Swartz","year":"2013","journal-title":"Elife"},{"key":"key20240126100521_b106-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s41048-018-0067-x","article-title":"Animal protein toxins: Origins and therapeutic applications","volume":"4","author":"Chen","year":"2018","journal-title":"Biophys Rep"},{"key":"key20240126100521_b107-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jmb.2014.07.027","article-title":"From foe to friend: Using animal toxins to investigate ion channel function","volume":"427","author":"Kalia","year":"2015","journal-title":"J Mol Biol"},{"issue":"107","key":"key20240126100521_b108-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9030107","article-title":"The Molecular basis of toxins' interactions with intracellular signaling via discrete portals","volume":"9","author":"Lahiani","year":"2017","journal-title":"Toxins (Basel)"},{"issue":"e148118","key":"key20240126100521_b109-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-JVATITD-1481-18","article-title":"Scorpion toxins targeting Kv1.3 channels: Insights into immunosuppression","volume":"25","author":"Oliveira","year":"2019","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"key20240126100521_b110-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.toxicon.2018.04.032","article-title":"Scorpion toxins to unravel the conundrum of ion channel structure and functioning","volume":"150","author":"Ortiz","year":"2018","journal-title":"Toxicon"},{"key":"key20240126100521_b111-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.toxicon.2013.07.012","article-title":"Scorpion venom components that affect ion-channels function","volume":"76","author":"Quintero-Hern\u00e1ndez","year":"2013","journal-title":"Toxicon"},{"key":"key20240126100521_b112-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"848","DOI":"10.2174\/1389201019666181105160744","article-title":"Scorpion toxins targeting Voltage-Gated sodium channels associated with pain","volume":"19","author":"Xu","year":"2018","journal-title":"Curr Pharm Biotechnol"},{"key":"key20240126100521_b113-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"30719","DOI":"10.1074\/jbc.M112.370742","article-title":"Mapping the interaction site for a \u03b2-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels","volume":"287","author":"Zhang","year":"2012","journal-title":"J Biol Chem"},{"key":"key20240126100521_b114-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2017.11.025","article-title":"Neuropharmacology of venom peptides","volume":"127","author":"Adams","year":"2017","journal-title":"Neuropharmacology"},{"key":"key20240126100521_b115-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1152\/physrev.00035.2012","article-title":"Computational methods of studying the binding of toxins from venomous animals to biological ion channels: Theory and applications","volume":"93","author":"Gordon","year":"2013","journal-title":"Physiol Rev"},{"key":"key20240126100521_b116-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuropharm.2017.07.002","article-title":"Venom-Derived peptide inhibitors of Voltage-Gated potassium channels","volume":"127","author":"Norton","year":"2017","journal-title":"Neuropharmacology"},{"key":"key20240126100521_b117-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1111\/j.1742-4658.2012.08545.x","article-title":"Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom","volume":"279","author":"Cologna","year":"2012","journal-title":"FEBS J"},{"issue":"913","key":"key20240126100521_b118-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00913","article-title":"Voltage-gated K+\/Na+ channels and scorpion venom toxins in cancer","volume":"11","author":"D\u00edaz-Garc\u00eda","year":"2020","journal-title":"Front Pharmacol"},{"issue":"eaau2596","key":"key20240126100521_b119-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau2596","article-title":"Structural basis for the modulation of voltage-gated sodium channels by animal toxins","volume":"362","author":"Shen","year":"2018","journal-title":"Science"},{"key":"key20240126100521_b120-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1021\/acschemneuro.7b00406","article-title":"Selective Voltage-Gated sodium channel peptide toxins from animal venom: Pharmacological probes and analgesic drug development","volume":"9","author":"Wu","year":"2018","journal-title":"ACS Chem Neurosci"},{"issue":"496","key":"key20240126100521_b121-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10120496","article-title":"Chlorotoxin-a multimodal imaging platform for targeting glioma tumors","volume":"10","author":"Cohen","year":"2018","journal-title":"Toxins (Basel)"},{"key":"key20240126100521_b122-BR-20-2-01704","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3390\/toxins7041079","article-title":"Chlorotoxin: A helpful natural scorpion peptide to diagnose glioma and fight tumor invasion","volume":"7","author":"Dardevet","year":"2015","journal-title":"Toxins (Basel)"},{"issue":"eaaw2672","key":"key20240126100521_b123-BR-20-2-01704","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw2672","article-title":"Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma","volume":"12","author":"Wang","year":"2020","journal-title":"Sci Transl Med"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T08:05:30Z","timestamp":1706256330000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2023.1704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":123,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,12,7]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2023.1704","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"article-number":"16"}}