{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:36:36Z","timestamp":1790634996173,"version":"4.1.0"},"reference-count":65,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2024.1773","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T09:49:12Z","timestamp":1712224152000},"source":"Crossref","is-referenced-by-count":13,"title":["<i>In vivo<\/i> protective effects of 6\u2011gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti\u2011apoptotic pathways"],"prefix":"10.3892","volume":"20","author":[{"given":"Ratchaniporn","family":"Kongsui","sequence":"first","affiliation":[{"name":"Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinatta","family":"Jittiwat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"issue":"322","key":"key20240521122329_b1-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02353-y","article-title":"Stroke risk factors, subtypes and outcome in elderly Thai patients","volume":"21","author":"Samuthpongtorn","year":"2021","journal-title":"BMC Neurol"},{"issue":"7275063","key":"key20240521122329_b2-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7275063","article-title":"In-hospital mortality among ischemic stroke patients in Gondar University Hospital: A retrospective cohort study","volume":"2019","author":"Gebreyohannes","year":"2019","journal-title":"Stroke Res Treat"},{"issue":"32","key":"key20240521122329_b3-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1186\/s13561-023-00439-6","article-title":"The costs associated with stroke care continuum: A systematic review","volume":"13","author":"Lucas-Noll","year":"2023","journal-title":"Health Econ Rev"},{"key":"key20240521122329_b4-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2147\/JIR.S275595","article-title":"Reactive Oxygen Species: Drivers of Physiological and Pathological Processes","volume":"13","author":"Checa","year":"2020","journal-title":"J Inflamm Res"},{"key":"key20240521122329_b5-BR-20-6-01773","author":"Zivancevic"},{"key":"key20240521122329_b6-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"28","key":"key20240521122329_b7-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00028","article-title":"Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury","volume":"13","author":"Wu","year":"2020","journal-title":"Front Mol Neurosci"},{"issue":"215","key":"key20240521122329_b8-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: Molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"key20240521122329_b9-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s12264-022-00859-0","article-title":"Neuronal death mechanisms and therapeutic strategy in ischemic stroke","volume":"38","author":"Mao","year":"2022","journal-title":"Neurosci Bull"},{"issue":"2158","key":"key20240521122329_b10-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29475-2","article-title":"Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats","volume":"13","author":"Otsuka","year":"2023","journal-title":"Sci Rep"},{"key":"key20240521122329_b11-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3892\/etm.2015.2462","article-title":"Caspase-3 inhibitor prevents the apoptosis of brain tissue in rats with acute cerebral infarction","volume":"10","author":"Sun","year":"2015","journal-title":"Exp Ther Med"},{"key":"key20240521122329_b12-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4103\/1673-5374.286946","article-title":"Oxidative stress battles neuronal Bcl-xL in a fight to the death","volume":"16","author":"Park","year":"2021","journal-title":"Neural Regen Res"},{"key":"key20240521122329_b13-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1515\/tnsci-2022-0268","article-title":"Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke","volume":"13","author":"Gao","year":"2022","journal-title":"Transl Neurosci"},{"key":"key20240521122329_b14-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jocn.2020.04.085","article-title":"Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats","volume":"78","author":"Zhu","year":"2020","journal-title":"J Clin Neurosci"},{"issue":"3300327","key":"key20240521122329_b15-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3300327","article-title":"p38 MAPK Endogenous inhibition improves neurological deficits in global cerebral ischemia\/reperfusion mice","volume":"2022","author":"Hou","year":"2022","journal-title":"Neural Plast"},{"issue":"1384","key":"key20240521122329_b16-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091384","article-title":"The alterations in mitochondrial dynamics following cerebral ischemia\/reperfusion injury","volume":"10","author":"Vongsfak","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"tkad018","key":"key20240521122329_b17-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad018","article-title":"Targeting neuronal mitophagy in ischemic stroke: An update","volume":"11","author":"Li","year":"2023","journal-title":"Burns Trauma"},{"issue":"2504798","key":"key20240521122329_b18-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2504798","article-title":"The role of mitochondrial dynamin in stroke","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"26","key":"key20240521122329_b19-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3892\/br.2023.1608","article-title":"Ameliorative effects of 6-gingerol in cerebral ischemia are mediated via the activation of antioxidant and anti-inflammatory pathways","volume":"18","author":"Kongsui","year":"2023","journal-title":"Biomed Rep"},{"issue":"317","key":"key20240521122329_b20-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13030317","article-title":"6-Gingerol, a bioactive compound of ginger attenuates renal damage in streptozotocin-induced diabetic rats by regulating the oxidative stress and inflammation","volume":"13","author":"Almatroodi","year":"2021","journal-title":"Pharmaceutics"},{"key":"key20240521122329_b21-BR-20-6-01773","first-page":"1027","article-title":"Biological properties of 6-gingerol: A brief review","volume":"9","author":"Wang","year":"2014","journal-title":"Nat Prod Commun"},{"issue":"185","key":"key20240521122329_b22-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/foods8060185","article-title":"Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe)","volume":"8","author":"Mao","year":"2019","journal-title":"Foods"},{"issue":"119842","key":"key20240521122329_b23-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119842","article-title":"Dihydrocapsaicin effectively mitigates cerebral ischemia-induced pathological changes in vivo, partly via antioxidant and anti-apoptotic pathways","volume":"283","author":"Jittiwat","year":"2021","journal-title":"Life Sci"},{"issue":"e13660","key":"key20240521122329_b24-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13660","article-title":"6-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat","volume":"45","author":"Adetuyi","year":"2021","journal-title":"J Food Biochem"},{"issue":"1204709","key":"key20240521122329_b25-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1204709","article-title":"Baihui point laser acupuncture ameliorates cognitive impairment, motor deficit, and neuronal loss partly via antioxidant and anti-inflammatory effects in an animal model of focal ischemic stroke","volume":"2019","author":"Jittiwat","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20240521122329_b26-BR-20-6-01773","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"key20240521122329_b27-BR-20-6-01773","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0021-9258(18)56216-5","article-title":"Photometric determination of catalase activity","volume":"187","author":"Goldblith","year":"1950","journal-title":"J Biol Chem"},{"key":"key20240521122329_b28-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuint.2016.12.007","article-title":"Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke","volume":"107","author":"Davis","year":"2017","journal-title":"Neurochem Int"},{"issue":"1274","key":"key20240521122329_b29-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121274","article-title":"Gingerol, a natural antioxidant, attenuates hyperglycemia and downstream complications","volume":"2","author":"Alharbi","year":"2022","journal-title":"Metabolites"},{"key":"key20240521122329_b30-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1177\/0960327117751235","article-title":"Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice","volume":"37","author":"Ajayi","year":"2018","journal-title":"Hum Exp Toxicol"},{"issue":"4748447","key":"key20240521122329_b31-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4748447","article-title":"Ginger for healthy ageing: A systematic review on current evidence of its antioxidant, anti-inflammatory, and anticancer properties","volume":"2022","author":"Ozkur","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"key20240521122329_b32-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cbi.2017.03.017","article-title":"Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats","volume":"270","author":"Abolaji","year":"2017","journal-title":"Chem Biol Interact"},{"issue":"3202","key":"key20240521122329_b33-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063202","article-title":"Involvement of Bcl-xL in neuronal function and development","volume":"22","author":"Bas","year":"2021","journal-title":"Int J Mol Sci"},{"key":"key20240521122329_b34-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"e331","DOI":"10.1161\/STROKEAHA.108.531632","article-title":"Apoptotic mechanisms after cerebral ischemia","volume":"40","author":"Broughton","year":"2009","journal-title":"Stroke"},{"key":"key20240521122329_b35-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4103\/bc.bc_27_16","article-title":"Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: Implications for chronic neurodegeneration","volume":"3","author":"Glushakova","year":"2017","journal-title":"Brain Circ"},{"key":"key20240521122329_b36-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3892\/mmr.2018.9771","article-title":"Magnesium sulfate ameliorates carbon monoxide-induced cerebral injury in male rats","volume":"19","author":"Bagheri","year":"2019","journal-title":"Mol Med Rep"},{"key":"key20240521122329_b37-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3892\/br.2013.153","article-title":"Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats","volume":"1","author":"Liu","year":"2013","journal-title":"Biomed Rep"},{"key":"key20240521122329_b38-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopen.2017.02.002","article-title":"Putative roles of mitochondrial Voltage-Dependent Anion Channel, Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis","volume":"4","author":"Gupta","year":"2017","journal-title":"Biochim Open"},{"key":"key20240521122329_b39-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.3949\/ccjm.71.suppl_1.s25","article-title":"Pathophysiology of acute ischemic stroke","volume":"71 (Suppl 1)","author":"Yenari","year":"2004","journal-title":"Cleve Clin J Med"},{"key":"key20240521122329_b40-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.3892\/ijmm.2018.3484","article-title":"Cognitive improvement following ischemia\/reperfusion injury induced by voluntary running-wheel exercise is associated with LncMALAT1-mediated apoptosis inhibition","volume":"41","author":"Shang","year":"2018","journal-title":"Int J Mol Med"},{"issue":"114481","key":"key20240521122329_b41-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114481","article-title":"A preparation of Ginkgo biloba L. leaves extract inhibits the apoptosis of hippocampal neurons in post-stroke mice via regulating the expression of Bax\/Bcl-2 and Caspase-3","volume":"280","author":"Li","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"key20240521122329_b42-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/kjm2.12486","article-title":"Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210\/brain-derived neurotrophic factor axis","volume":"38","author":"Zhai","year":"2022","journal-title":"Kaohsiung J Med Sci"},{"issue":"6661937","key":"key20240521122329_b43-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6661937","article-title":"6-Gingerol, a major ingredient of ginger attenuates diethylnitrosamine-induced liver injury in rats through the modulation of oxidative stress and anti-inflammatory activity","volume":"2021","author":"Alsahli","year":"2021","journal-title":"Mediators Inflamm"},{"issue":"108146","key":"key20240521122329_b44-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108146","article-title":"6-Gingerol protects against cerebral ischemia\/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1\/FAF1 complex dissociation-mediated autophagy","volume":"100","author":"Luo","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"key20240521122329_b45-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1016\/j.bbadis.2018.03.014","article-title":"New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis","volume":"1864","author":"Verma","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1499","key":"key20240521122329_b46-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2023.1499","article-title":"The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats","volume":"17","author":"Mohammed","year":"2023","journal-title":"Ecancermedicalscience"},{"key":"key20240521122329_b47-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/s0028-3908(02)00093-x","article-title":"The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats","volume":"43","author":"Tortiglione","year":"2002","journal-title":"Neuropharmacology"},{"key":"key20240521122329_b48-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1161\/01.str.31.9.2112","article-title":"Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients","volume":"31","author":"Kessler","year":"2000","journal-title":"Stroke"},{"key":"key20240521122329_b49-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.brainres.2017.09.013","article-title":"Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways","volume":"1676","author":"Yang","year":"2017","journal-title":"Brain Res"},{"issue":"1053","key":"key20240521122329_b50-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101053","article-title":"MiRNA: Involvement of the MAPK pathway in ischemic stroke. A promising therapeutic target","volume":"57","author":"Gugliandolo","year":"2021","journal-title":"Medicina (Kaunas)"},{"issue":"110853","key":"key20240521122329_b51-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110853","article-title":"MicroRNAs as regulators of ERK\/MAPK pathway: A comprehensive review","volume":"132","author":"Safa","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"154854","key":"key20240521122329_b52-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154854","article-title":"6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis","volume":"125","author":"Zhang","year":"2020","journal-title":"Cytokine"},{"key":"key20240521122329_b53-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1080\/21691401.2019.1606010","article-title":"6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103\/BNIP3","volume":"47","author":"Kang","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"key20240521122329_b54-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol"},{"issue":"786099","key":"key20240521122329_b55-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.786099","article-title":"Mitochondrial quality control: A pathophysiological mechanism and therapeutic target for stroke","volume":"14","author":"Yang","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"key20240521122329_b56-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.15252\/embj.201488327","article-title":"Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death","volume":"33","author":"Martorell-Riera","year":"2014","journal-title":"EMBO J"},{"issue":"574","key":"key20240521122329_b57-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030574","article-title":"Oxidative stress in ischemia\/reperfusion injuries following acute ischemic stroke","volume":"10","author":"Jurcau","year":"2022","journal-title":"Biomedicines"},{"issue":"4384","key":"key20240521122329_b58-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204384","article-title":"Ginger root extract improves GI health in diabetic rats by improving intestinal integrity and mitochondrial function","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"issue":"2564","key":"key20240521122329_b59-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112564","article-title":"Modulating effects of zingiberaceae phenolic compounds on neurotrophic factors and their potential as neuroprotectants in brain disorders and age-associated neurodegenerative disorders: A review","volume":"15","author":"Razak","year":"2023","journal-title":"Nutrients"},{"key":"key20240521122329_b60-BR-20-6-01773","first-page":"311","article-title":"Biological actions of drug solvents","volume":"113","author":"Kelava","year":"2011","journal-title":"Periodicum Biologorum"},{"key":"key20240521122329_b61-BR-20-6-01773","first-page":"9","article-title":"Dimethyl Sulfoxide and Their Toxicity","volume":"5","author":"Kurdi","year":"2019","journal-title":"Int J Res Biol Pharm"},{"key":"key20240521122329_b62-BR-20-6-01773","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jim.2010.01.014","article-title":"Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hours","volume":"356","author":"Kloverpris","year":"2010","journal-title":"J Immunol Methods"},{"issue":"10556","key":"key20240521122329_b63-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11181-5","article-title":"Dihydrocapsaicin attenuates blood brain barrier and cerebral damage in focal cerebral ischemia\/reperfusion via oxidative stress and inflammatory","volume":"7","author":"Janyou","year":"2017","journal-title":"Sci Rep"},{"issue":"294","key":"key20240521122329_b64-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00294","article-title":"Glial cells: Role of the immune response in ischemic stroke","volume":"11","author":"Xu","year":"2020","journal-title":"Front Immunol"},{"issue":"147","key":"key20240521122329_b65-BR-20-6-01773","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00147","article-title":"Rational modulation of the innate immune system for neuroprotection in ischemic stroke","volume":"9","author":"Amantea","year":"2015","journal-title":"Front Neurosci"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T09:23:41Z","timestamp":1716283421000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2024.1773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,4,4]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2024.1773","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"article-number":"85"}}