{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:05:34Z","timestamp":1782507934295,"version":"3.54.5"},"reference-count":47,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2025.2022","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:15:36Z","timestamp":1750317336000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["<i>CRY2<\/i> (rs11605924) and <i>G6PC2<\/i> (rs560887) single nucleotide polymorphisms increase risk of type 2 diabetes mellitus"],"prefix":"10.3892","volume":"23","author":[{"given":"Elvis Ngwa","family":"Ndonwi","sequence":"first","affiliation":[{"name":"South African Medical Research Council\/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Matshazi","sequence":"additional","affiliation":[{"name":"South African Medical Research Council\/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Davison","sequence":"additional","affiliation":[{"name":"South African Medical Research Council\/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Erasmus","sequence":"additional","affiliation":[{"name":"South African Medical Research Council\/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Kengne","sequence":"additional","affiliation":[{"name":"Non\u2011Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tandi","family":"Matsha","sequence":"additional","affiliation":[{"name":"South African Medical Research Council\/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"key20250812092507_b1-BR-23-3-02022"},{"key":"key20250812092507_b2-BR-23-3-02022","author":"Vijan"},{"key":"key20250812092507_b3-BR-23-3-02022"},{"issue":"1","key":"key20250812092507_b4-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-016-0039-3","article-title":"Diabetes and its drivers: The largest epidemic in human history?","volume":"3","author":"Zimmet","year":"2017","journal-title":"Clin Diabetes Endocrinol"},{"key":"key20250812092507_b5-BR-23-3-02022"},{"issue":"206","key":"key20250812092507_b6-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4117-y","article-title":"Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural South Africa: the HAALSI (health and aging in Africa: longitudinal studies of INDEPTH communities) study","volume":"17","author":"Gaziano","year":"2017","journal-title":"BMC Public Health"},{"key":"key20250812092507_b7-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.2337\/diabetes.49.12.2201","article-title":"Parental transmission of type 2 diabetes: The Framingham Offspring Study","volume":"49","author":"Meigs","year":"2000","journal-title":"Diabetes"},{"key":"key20250812092507_b8-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s001250051131","article-title":"Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study","volume":"42","author":"Poulsen","year":"1999","journal-title":"Diabetologia"},{"key":"key20250812092507_b9-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2337\/diab.36.1.93","article-title":"Age-corrected empirical genetic risk estimates for first-degree relatives of IDDM patients","volume":"36","author":"Tillil","year":"1987","journal-title":"Diabetes"},{"key":"key20250812092507_b10-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.genom.4.070802.110436","article-title":"The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits","volume":"4","author":"Florez","year":"2003","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"key20250812092507_b11-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00125-012-2715-x","article-title":"The link between Family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: The EPIC-InterAct study","volume":"56","author":"Scott","year":"2013","journal-title":"Diabetologia"},{"key":"key20250812092507_b12-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/jdi.14359","article-title":"Gender-specific genetic influence of rs1111875 on diabetes risk: Insights from the Taiwan biobank study","volume":"16","author":"Chiang","year":"2025","journal-title":"J Diabetes Investig"},{"issue":"26","key":"key20250812092507_b13-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0148-z","article-title":"Contribution of the TCF7L2 rs7903146 (C\/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon","volume":"14","author":"Guewo-Fokeng","year":"2015","journal-title":"J Diabetes Metab Disord"},{"issue":"12764","key":"key20250812092507_b14-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69363-7","article-title":"PPARG (Pro12Ala) genetic variant and risk of T2DM: A systematic review and meta-analysis","volume":"10","author":"Sarhangi","year":"2020","journal-title":"Sci Rep"},{"key":"key20250812092507_b15-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1590\/1414-431x20132677","article-title":"Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: A meta-analysis","volume":"46","author":"Wang","year":"2013","journal-title":"Braz J Med Biol Res"},{"key":"key20250812092507_b16-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/19323","article-title":"Mammalian CRY1 and CRY2 are essential for maintenance of circadian rhythms","volume":"398","author":"Van der Horst","year":"1999","journal-title":"Nature"},{"key":"key20250812092507_b17-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1172\/JCI2548","article-title":"Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice","volume":"101","author":"Pontoglio","year":"1998","journal-title":"J Clin Invest"},{"key":"key20250812092507_b18-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/ng.520","article-title":"New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk","volume":"42","author":"Dupuis","year":"2010","journal-title":"Nat Genet"},{"key":"key20250812092507_b19-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/ng.2897","article-title":"Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility","volume":"46","author":"Mahajan","year":"2014","journal-title":"Nat Genet"},{"key":"key20250812092507_b20-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00125-008-1241-3","article-title":"A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population","volume":"52","author":"Hu","year":"2009","journal-title":"Diabetologia"},{"key":"key20250812092507_b21-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"758","DOI":"10.4103\/ijem.IJEM_156_17","article-title":"Sleep disorders in type 2 diabetes","volume":"21","author":"Khandelwal","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"issue":"e21464","key":"key20250812092507_b22-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021464","article-title":"Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"key20250812092507_b23-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.2337\/db18-0133","article-title":"The Common HNF1A Variant I27L Is a modifier of age at diabetes diagnosis in individuals with HNF1A-MODY","volume":"67","author":"Locke","year":"2018","journal-title":"Diabetes"},{"issue":"51","key":"key20250812092507_b24-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0375-2","article-title":"HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey","volume":"19","author":"Beysel","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"key20250812092507_b25-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.diabet.2014.04.009","article-title":"Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight","volume":"41","author":"Morita","year":"2015","journal-title":"Diabetes Metab"},{"key":"key20250812092507_b26-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ydbio.2005.07.021","article-title":"Prox1 activity controls pancreas morphogenesis and participates in the production of \u2018secondary transition\u2019 pancreatic endocrine cells","volume":"286","author":"Wang","year":"2005","journal-title":"Dev Biol"},{"key":"key20250812092507_b27-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s00125-010-1753-5","article-title":"Variants at DGKB\/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people","volume":"53","author":"Boesgaard","year":"2010","journal-title":"Diabetologia"},{"key":"key20250812092507_b28-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.2337\/db10-1575","article-title":"Association of genetic Loci with glucose levels in childhood and adolescence: A meta-analysis of over 6000 children","volume":"60","author":"Barker","year":"2011","journal-title":"Diabetes"},{"issue":"104","key":"key20250812092507_b29-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11020104","article-title":"Single nucleotide polymorphisms associated with metformin and sulphonylureas' glycaemic response among South African adults with type 2 diabetes mellitus","volume":"11","author":"Masilela","year":"2021","journal-title":"J Pers Med"},{"key":"key20250812092507_b30-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2147\/PGPM.S305020","article-title":"A Two-stage study identifies two novel polymorphisms in PRKAG2 affecting metformin response in Chinese type 2 diabetes patients","volume":"14","author":"Xiao","year":"2021","journal-title":"Pharmgenomics Pers Med"},{"key":"key20250812092507_b31-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.diabres.2016.01.003","article-title":"Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses","volume":"114","author":"Yako","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"key20250812092507_b32-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pcd.2017.01.004","article-title":"Alternative indices of glucose homeostasis as biochemical diagnostic tests for abnormal glucose tolerance in an African setting. Prim","volume":"11","author":"Kengne","year":"2017","journal-title":"Care Diabetes"},{"key":"key20250812092507_b33-BR-23-3-02022","author":"Kristin"},{"key":"key20250812092507_b34-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"841","DOI":"10.7196\/samj.5670","article-title":"High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: Baseline data of a study in Bellville, Cape Town","volume":"102 (11 Pt 1)","author":"Erasmus","year":"2012","journal-title":"S Afr Med J"},{"issue":"1215","key":"key20250812092507_b35-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"key20250812092507_b36-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"key20250812092507_b37-BR-23-3-02022","first-page":"164","article-title":"Diagnosis management and prevention of the common dyslipidaemias in South Africa - clinical guideline, 2000. South African Medical Association and Lipid and Atherosclerosis Society of Southern Africa Working Group","volume":"90 (2 Pt2)","year":"2000","journal-title":"S Afr Med J"},{"key":"key20250812092507_b38-BR-23-3-02022"},{"key":"key20250812092507_b39-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/joim.12903","article-title":"Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus","volume":"286","author":"Arora","year":"2019","journal-title":"J Intern Med"},{"key":"key20250812092507_b40-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/MED.0000000000000082","article-title":"Metabolic effects of sleep disruption, links to obesity and diabetes","volume":"21","author":"Nedeltcheva","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"key20250812092507_b41-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"H1036","DOI":"10.1152\/ajpheart.01291.2007","article-title":"Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression","volume":"294","author":"Bray","year":"2008","journal-title":"Am J Physiol-Hear Circ Physiol"},{"key":"key20250812092507_b42-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s00125-019-05059-6","article-title":"Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes","volume":"63","author":"Mason","year":"2020","journal-title":"Diabetologia"},{"key":"key20250812092507_b43-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1126\/science.1156849","article-title":"A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels","volume":"320","author":"Bouatia-Naji","year":"2008","journal-title":"Science"},{"key":"key20250812092507_b44-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1172\/JCI34566","article-title":"Variations in the G6PC2\/ABCB11 genomic region are associated with fasting glucose levels","volume":"118","author":"Chen","year":"2008","journal-title":"J Clin Invest"},{"key":"key20250812092507_b45-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000268019","article-title":"Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals","volume":"56","author":"Demirci","year":"2010","journal-title":"Ann Nutr Metab"},{"issue":"e0181232","key":"key20250812092507_b46-BR-23-3-02022","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181232","article-title":"Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes","volume":"12","author":"Shi","year":"2017","journal-title":"PLoS One"},{"key":"key20250812092507_b47-BR-23-3-02022","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1007\/s00125-006-0450-x","article-title":"Common variants in HNF-1 alpha and risk of type 2 diabetes","volume":"49","author":"Holmkvist","year":"2006","journal-title":"Diabetologia"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T06:25:13Z","timestamp":1754979913000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2025.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,19]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2025.2022","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]}}}