{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:59:13Z","timestamp":1773860353252,"version":"3.50.1"},"reference-count":32,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2026.2119","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:25:09Z","timestamp":1770884709000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["<i>COX\u20112<\/i>\n                    rs20417 polymorphism and susceptibility to type 2 diabetes mellitus"],"prefix":"10.3892","volume":"24","author":[{"given":"Nosayba","family":"Al\u2011azzam","sequence":"first","affiliation":[{"name":"Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrouq","family":"Al Fraihat","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Elsalem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khawla","family":"Mhedat","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesreen","family":"Saadeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"issue":"1415","key":"key20260318135132_b1-BR-24-4-02119","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09502-x","article-title":"Trends in the incidence of diabetes mellitus: Results from the global burden of disease study 2017 and implications for diabetes mellitus prevention","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Public Health"},{"key":"key20260318135132_b2-BR-24-4-02119","author":"Arokiasamy"},{"key":"key20260318135132_b3-BR-24-4-02119","first-page":"838","article-title":"A review on diabetes mellitus: Type1 & Type2","volume":"9","author":"Kumar","year":"2020","journal-title":"World J Pharm Pharm Sci"},{"key":"key20260318135132_b4-BR-24-4-02119","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","article-title":"Type 2 diabetes","volume":"400","author":"Ahmad","year":"2022","journal-title":"Lancet"},{"issue":"21001","key":"key20260318135132_b5-BR-24-4-02119","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77970-7","article-title":"Characterizing the type 2 diabetes mellitus epidemic in Jordan up to 2050","volume":"10","author":"Awad","year":"2020","journal-title":"Sci Rep"},{"key":"key20260318135132_b6-BR-24-4-02119","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diabet.2011.11.006","article-title":"Inflammation and type 2 diabetes","volume":"38","author":"Calle","year":"2012","journal-title":"Diabetes Metab"},{"key":"key20260318135132_b7-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1161\/01.CIR.0000124718.99562.91","article-title":"Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population","volume":"109","author":"Helmersson","year":"2004","journal-title":"Circulation"},{"key":"key20260318135132_b8-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0090-6980(02)00029-1","article-title":"Distinct functions of COX-1 and COX-2","volume":"68-69","author":"Morita","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"key20260318135132_b9-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1124\/pr.56.3.3","article-title":"Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition","volume":"56","author":"Simmons","year":"2004","journal-title":"Pharmacol Rev"},{"key":"key20260318135132_b10-BR-24-4-02119","first-page":"15","article-title":"COX-1 and COX-2 tissue expression: Implications and predictions","volume":"49","author":"Crofford","year":"1997","journal-title":"J Rheumatol Suppl"},{"issue":"901616","key":"key20260318135132_b11-BR-24-4-02119","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.901616","article-title":"The role of interleukin-1\u03b2 in type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"13","author":"Alfadul","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20260318135132_b12-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.2337\/diabetes.51.6.1772","article-title":"Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function","volume":"51","author":"Tran","year":"2002","journal-title":"Diabetes"},{"key":"key20260318135132_b13-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1507\/endocrj.EJ19-0015","article-title":"Opposing effects of IL-1\u03b2\/COX-2\/PGE2 pathway loop on islets in type 2 diabetes mellitus","volume":"66","author":"Wang","year":"2019","journal-title":"Endocr J"},{"key":"key20260318135132_b14-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00005082-200201000-00003","article-title":"Risk factors for type 2 diabetes mellitus","volume":"16","author":"Fletcher","year":"2002","journal-title":"J Cardiovasc Nurs"},{"issue":"70","key":"key20260318135132_b15-BR-24-4-02119","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00738-1","article-title":"Association of IL-10 (- 1082 A\/G) and IL-6 (- 174 G\/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population","volume":"21","author":"Ayelign","year":"2021","journal-title":"BMC Endocr Disord"},{"key":"key20260318135132_b16-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/15257770.2024.2343904","article-title":"Angiotensin-converting enzyme I\/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals","volume":"44","author":"Momeni-Moghaddam","year":"2025","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"101258","key":"key20260318135132_b17-BR-24-4-02119","article-title":"Amino-acid amendment of arginine-325-tryptophan in rs13266634 genetic polymorphism studies of the SLC30A8 gene with type 2 diabetes-mellitus patients featuring a positive family history in the Saudi population","volume":"33","author":"Alharbi","year":"2021","journal-title":"J King Saud Univ Sci"},{"key":"key20260318135132_b18-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.plefa.2018.07.012","article-title":"Genetic variant in the 3'-untranslated region of the COX2 gene is associated with type 2 diabetes: A hospital-based case-control study","volume":"137","author":"Ozbayer","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"key20260318135132_b19-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00439-003-1000-y","article-title":"Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians","volume":"113","author":"Konheim","year":"2003","journal-title":"Hum Genet"},{"key":"key20260318135132_b20-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1042\/bj3020723","article-title":"Structure of the human cyclo-oxygenase-2 gene","volume":"302","author":"Appleby","year":"1994","journal-title":"Biochem J"},{"key":"key20260318135132_b21-BR-24-4-02119","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0022-3565(24)29252-1","article-title":"Functional characterization of cyclooxygenase-2 polymorphisms","volume":"299","author":"Fritsche","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"key20260318135132_b22-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"issue":"2","key":"key20260318135132_b23-BR-24-4-02119","article-title":"The-765G> C cyclooxygenase-2 promoter polymorphism is associated with type 2 diabetes mellitus, low high-density lipoprotein and manifest angina","volume":"7","author":"Churm","year":"2016","journal-title":"J Diabetes Metab"},{"key":"key20260318135132_b24-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Mart\u00edn-V\u00e1zquez","year":"2023","journal-title":"Int J Biol Sci"},{"key":"key20260318135132_b25-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"29330","DOI":"10.1074\/jbc.M602424200","article-title":"Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets","volume":"281","author":"Oshima","year":"2006","journal-title":"J Biol Chem"},{"key":"key20260318135132_b26-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.atherosclerosis.2008.07.018","article-title":"Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the diabetes heart study","volume":"203","author":"Rudock","year":"2009","journal-title":"Atherosclerosis"},{"issue":"e884","key":"key20260318135132_b27-BR-24-4-02119","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.884","article-title":"Genetic polymorphisms analysis of pharmacogenomic VIP variants in Bai ethnic group from China","volume":"7","author":"Chen","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"key20260318135132_b28-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1093\/eurheartj\/ehu168","article-title":"Association of cyclooxygenase-2 genetic variant with cardiovascular disease","volume":"35","author":"Ross","year":"2014","journal-title":"Eur Heart J"},{"key":"key20260318135132_b29-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1161\/01.atv.0000030340.80207.c5","article-title":"Common promoter variant in cyclooxygenase-2 represses gene expression: Evidence of role in acute-phase inflammatory response","volume":"22","author":"Papafili","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20260318135132_b30-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1155\/JBB.2005.104","article-title":"Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes","volume":"2005","author":"Wren","year":"2005","journal-title":"J Biomed Biotechnol"},{"key":"key20260318135132_b31-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/s0167-4781(96)00225-4","article-title":"Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-beta response element","volume":"1350","author":"Yang","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"key20260318135132_b32-BR-24-4-02119","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.2337\/diabetes.47.9.1379","article-title":"Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis","volume":"47","author":"Robertson","year":"1998","journal-title":"Diabetes"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:51:37Z","timestamp":1773834697000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2026.2119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2,12]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2026.2119","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}