{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:03:30Z","timestamp":1789470210084,"version":"build-2803163510"},"reference-count":46,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2026.2192","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:56:36Z","timestamp":1787900196000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Immunological profiles of natural killer cells and their subpopulations in overweight and obesity class\u2011I individuals stratified by two\u2011dimensional categories of lipid profiles and body mass index"],"prefix":"10.3892","volume":"25","author":[{"given":"Arpa","family":"Surapaitoon","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiatichai","family":"Faksri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punnapat","family":"Nawawishkarun","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supranee","family":"Phanthanawiboon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingkan","family":"Jaisiri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auttawit","family":"Sirichoat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parama","family":"Budmala","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnone","family":"Nithichanon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amonrat","family":"Jumnainsong","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanin","family":"Salao","sequence":"additional","affiliation":[{"name":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels 1090, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisitsak","family":"Phoksawat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"102882","key":"key20260915131011_b1-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2024.102882","article-title":"The global burden of overweight-obesity and its association with economic status, benefiting from STEPs survey of WHO member states: A meta-analysis","volume":"46","author":"Islam","year":"2024","journal-title":"Prev Med Rep"},{"issue":"77","key":"key20260915131011_b2-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1464","article-title":"The silent surge: Obesity driving a global cardiovascular crisis","volume":"20","author":"Jeemon","year":"2025","journal-title":"Glob Heart"},{"key":"key20260915131011_b3-BR-25-4-02192"},{"issue":"373","key":"key20260915131011_b4-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020373","article-title":"The Asia-Pacific body mass index classification and new-onset chronic kidney disease in non-diabetic Japanese adults: A community-based longitudinal study from 1998 to 2023","volume":"13","author":"Okawa","year":"2025","journal-title":"Biomedicines"},{"key":"key20260915131011_b5-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"key20260915131011_b6-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s11883-023-01167-2","article-title":"Obesity and dyslipidemia","volume":"25","author":"Nussbaumerova","year":"2023","journal-title":"Curr Atheroscler Rep"},{"key":"key20260915131011_b7-BR-25-4-02192","doi-asserted-by":"crossref","first-page":"102","DOI":"10.14740\/jem819","article-title":"Risk of dyslipidemia in obese young adult subjects as measured by various obesity indices","volume":"12","author":"Yudin","year":"2022","journal-title":"J Endocrinol Metab"},{"issue":"108951","key":"key20260915131011_b8-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108951","article-title":"Biochemical and immunological changes in obesity","volume":"708","author":"Barakat","year":"2021","journal-title":"Arch Biochem Biophys"},{"key":"key20260915131011_b9-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41574-023-00932-2","article-title":"Emerging mechanisms of obesity-associated immune dysfunction","volume":"20","author":"Shaikh","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"245","key":"key20260915131011_b10-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00245","article-title":"Obesity-associated alterations of natural killer cells and immunosurveillance of cancer","volume":"11","author":"B\u00e4hr","year":"2020","journal-title":"Front Immunol"},{"key":"key20260915131011_b11-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2022.09.022","article-title":"Human natural killer cells: Form, function, and development","volume":"151","author":"Mace","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"108727","key":"key20260915131011_b12-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108727","article-title":"Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application","volume":"227","author":"Zuo","year":"2021","journal-title":"Clin Immunol"},{"key":"key20260915131011_b13-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"BE01","DOI":"10.7860\/JCDR\/2017\/26748.10469","article-title":"Natural killer cells-their role in tumour immunosurveillance","volume":"11","author":"Sharma","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"key20260915131011_b14-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cytogfr.2018.08.001","article-title":"Natural killer cells in inflammation and autoimmunity","volume":"42","author":"Zitti","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20260915131011_b15-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"258","DOI":"10.5114\/reum.2022.119042","article-title":"The phenotype of CD3-CD56bright and CD3-CD56dim natural killer cells in systemic lupus erythematosus patients and its relation to disease activity","volume":"60","author":"Soelistyoningsih","year":"2022","journal-title":"Reumatologia"},{"key":"key20260915131011_b16-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.imlet.2019.10.006","article-title":"CD3-CD56+ NK cells display an inflammatory profile in RR-MS patients","volume":"216","author":"Tahrali","year":"2019","journal-title":"Immunol Lett"},{"key":"key20260915131011_b17-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.clim.2016.01.007","article-title":"Alteration of natural Killer cell phenotype and function in obese individuals","volume":"177","author":"Viel","year":"2017","journal-title":"Clin Immunol"},{"issue":"42665","key":"key20260915131011_b18-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1038\/srep42665","article-title":"Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue","volume":"7","author":"Wouters","year":"2017","journal-title":"Sci Rep"},{"key":"key20260915131011_b19-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1210\/clinem\/dgaf283","article-title":"Dyslipidemia is associated with increased natural killer cell cytotoxicity and autoimmunity in women with recurrent pregnancy losses","volume":"111","author":"Zhang","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"key20260915131011_b20-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"655","DOI":"10.5551\/jat.17152","article-title":"Diagnostic criteria for dyslipidemia","volume":"20","author":"Teramoto","year":"2013","journal-title":"J Atheroscler Thromb"},{"key":"key20260915131011_b21-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"284","DOI":"10.7861\/clinmed.2023-0168","article-title":"Causes of obesity: A review","volume":"23","author":"Masood","year":"2023","journal-title":"Clin Med (Lond)"},{"key":"key20260915131011_b22-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"5573","DOI":"10.2147\/IJGM.S326628","article-title":"Investigation of lymphocyte subsets in peripheral blood of patients with dyslipidemia","volume":"14","author":"Xu","year":"2021","journal-title":"Int J Gen Med"},{"key":"key20260915131011_b23-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"C1563","DOI":"10.1152\/ajpcell.00043.2024","article-title":"Ox-LDL-induced CD80+ macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients","volume":"326","author":"Wang","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20260915131011_b24-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s12026-018-8989-4","article-title":"Impaired natural killer cell subset phenotypes in human obesity","volume":"66","author":"B\u00e4hr","year":"2018","journal-title":"Immunol Res"},{"key":"key20260915131011_b25-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.humimm.2016.11.006","article-title":"Natural killer cell subsets and receptor expression in peripheral blood mononuclear cells of a healthy Korean population: Reference range, influence of age and sex, and correlation between NK cell receptors and cytotoxicity","volume":"78","author":"Phan","year":"2017","journal-title":"Hum Immunol"},{"key":"key20260915131011_b26-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1111\/febs.16370","article-title":"Protein phosphatase 2A catalytic subunit \u03b2 suppresses PMA\/ionomycin-induced T-cell activation by negatively regulating PI3K\/Akt signaling","volume":"289","author":"Gao","year":"2022","journal-title":"FEBS J"},{"key":"key20260915131011_b27-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.3892\/mmr.2015.3646","article-title":"Leptin modulates the expression of catabolic genes in rat nucleus pulposus cells through the mitogen-activated protein kinase and Janus kinase 2\/signal transducer and activator of transcription 3 pathways","volume":"12","author":"Miao","year":"2015","journal-title":"Mol Med Rep"},{"issue":"704324","key":"key20260915131011_b28-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.704324","article-title":"Identification and characterization of a master transcription factor of Th1 cells, T-bet, within flounder (Paralichthys olivaceus)","volume":"12","author":"Tian","year":"2021","journal-title":"Front Immunol"},{"issue":"4021623","key":"key20260915131011_b29-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4021623","article-title":"Visfatin induces inflammation and insulin resistance via the NF-\u03baB and STAT3 signaling pathways in hepatocytes","volume":"2019","author":"Heo","year":"2019","journal-title":"J Diabetes Res"},{"issue":"869197","key":"key20260915131011_b30-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.869197","article-title":"Fatty acid metabolism and T cells in multiple sclerosis","volume":"13","author":"Pompura","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"key20260915131011_b31-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-014-0033-1","article-title":"Altered NK cell function in obese healthy humans","volume":"2","author":"Laue","year":"2015","journal-title":"BMC Obes"},{"issue":"e8660","key":"key20260915131011_b32-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008660","article-title":"Natural killer cells in obesity: Impaired function and increased susceptibility to the effects of cigarette smoke","volume":"5","author":"O'Shea","year":"2010","journal-title":"PLoS One"},{"issue":"4017","key":"key20260915131011_b33-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54390-5","article-title":"Real-time ex vivo monitoring of NK cell migration toward obesity-associated oesophageal adenocarcinoma following modulation of CX3CR1","volume":"14","author":"Mylod","year":"2024","journal-title":"Sci Rep"},{"issue":"573200","key":"key20260915131011_b34-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.573200","article-title":"Characterization of surface receptor expression and cytotoxicity of human NK cells and NK cell subsets in overweight and obese humans","volume":"11","author":"Naujoks","year":"2020","journal-title":"Front Immunol"},{"key":"key20260915131011_b35-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.atherosclerosis.2005.01.046","article-title":"Identification of natural killer cells in human atherosclerotic plaque","volume":"180","author":"Bobryshev","year":"2005","journal-title":"Atherosclerosis"},{"key":"key20260915131011_b36-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/cvr\/cvu016","article-title":"Natural killer (NK) cells augment atherosclerosis by cytotoxic-dependent mechanisms","volume":"102","author":"Selathurai","year":"2014","journal-title":"Cardiovasc Res"},{"issue":"1503","key":"key20260915131011_b37-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01503","article-title":"Symptomatic carotid atherosclerotic plaques are associated with increased infiltration of natural killer (NK) cells and higher serum levels of NK activating receptor ligands","volume":"10","author":"Bonaccorsi","year":"2019","journal-title":"Front Immunol"},{"key":"key20260915131011_b38-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.7326\/0003-4819-126-12-199706150-00028","article-title":"Lymphocyte subsets in severe atherosclerosis before revascularization","volume":"126","author":"Clerc","year":"1997","journal-title":"Ann Intern Med"},{"key":"key20260915131011_b39-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.tcm.2013.06.003","article-title":"Atherosclerosis and interferon-\u03b3: New insights and therapeutic targets","volume":"24","author":"Voloshyna","year":"2014","journal-title":"Trends Cardiovasc Med"},{"key":"key20260915131011_b40-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cvr\/cvn248","article-title":"CD4+ CD28 null T cells in coronary artery disease: When helpers become killers","volume":"81","author":"Dumitriu","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"587","key":"key20260915131011_b41-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00587","article-title":"Natural killer cells in kidney health and disease","volume":"10","author":"Turner","year":"2019","journal-title":"Front Immunol"},{"key":"key20260915131011_b42-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.kint.2017.02.006","article-title":"Interferon-\u03b3 production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression","volume":"92","author":"Law","year":"2017","journal-title":"Kidney Int"},{"key":"key20260915131011_b43-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.4049\/jimmunol.181.11.7489","article-title":"NK cells induce apoptosis in tubular epithelial cells and contribute to renal ischemia-reperfusion injury","volume":"181","author":"Zhang","year":"2008","journal-title":"J Immunol"},{"key":"key20260915131011_b44-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.clnu.2024.11.004","article-title":"Associations between blood markers of glucose metabolism and characteristics of circulating lymphocytes","volume":"43","author":"Schmitz","year":"2024","journal-title":"Clin Nutr"},{"key":"key20260915131011_b45-BR-25-4-02192","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.cmet.2016.03.002","article-title":"Adipose natural killer cells regulate adipose tissue macrophages to promote insulin resistance in obesity","volume":"23","author":"Lee","year":"2016","journal-title":"Cell Metab"},{"issue":"614429","key":"key20260915131011_b46-BR-25-4-02192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.614429","article-title":"Natural killer cells: Friend or foe in metabolic diseases?","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:10:17Z","timestamp":1789467017000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2026.2192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2026.2192","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}