{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:03:30Z","timestamp":1789470210017,"version":"build-2803163510"},"reference-count":75,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Rep"],"DOI":"10.3892\/br.2026.2194","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:37:37Z","timestamp":1788172657000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["Association between polyphenols and inhalation\u2011induced oxidative stress in chronic lung diseases: A systematic review"],"prefix":"10.3892","volume":"25","author":[{"given":"Alexander","family":"Gulyaev","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiyar","family":"Nurgaziyev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisher","family":"Ikromov","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaulym","family":"Nurgaziyeva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madina","family":"Baurzhan","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanat","family":"Tekebayev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayagul","family":"Kairgeldina","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarina","family":"Shulgau","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alibek","family":"Kossumov","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurlubek","family":"Katkenov","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samat","family":"Kozhakhmetov","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almagul","family":"Kushugulova","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shynggys","family":"Sergazy","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"170080","key":"key20260915131015_b1-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0080-2017","article-title":"Current and new challenges in occupational lung diseases","volume":"26","author":"De Matteis","year":"2017","journal-title":"Eur Respir Rev"},{"key":"key20260915131015_b2-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00420-024-02055-1","article-title":"Effects of occupational exposure to metal fume PM2.5 on lung function and biomarkers among shipyard workers: A 3-year prospective cohort study","volume":"97","author":"Tran","year":"2024","journal-title":"Int Arch Occup Environ Health"},{"issue":"210250","key":"key20260915131015_b3-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0250-2021","article-title":"Understanding the pathogenesis of occupational coal and silica dust-associated lung disease","volume":"31","author":"Vanka","year":"2022","journal-title":"Eur Respir Rev"},{"issue":"101941","key":"key20260915131015_b4-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2025.101941","article-title":"Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes","volume":"14","author":"Sherekar","year":"2025","journal-title":"Toxicol Rep"},{"issue":"8416763","key":"key20260915131015_b5-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"key20260915131015_b6-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"6646923","key":"key20260915131015_b7-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6646923","article-title":"Oxidative imbalance as a crucial factor in inflammatory lung diseases: Could antioxidant treatment constitute a new therapeutic strategy?","volume":"2021","author":"Victoni","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"key20260915131015_b8-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/s0891-5849(98)00302-5","article-title":"Can antioxidant vitamins materially reduce oxidative damage in humans?","volume":"26","author":"McCall","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"key20260915131015_b9-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: Beneficial effects from a mechanistic perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"key20260915131015_b10-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbrc.2022.08.098","article-title":"Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?","volume":"633","author":"Halliwell","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"CD007176","key":"key20260915131015_b11-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007176.pub2","article-title":"Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases","volume":"2012","author":"Bjelakovic","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"key20260915131015_b12-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1183\/09031936.06.00053805","article-title":"Oxidative stress and redox regulation of lung inflammation in COPD","volume":"28","author":"Rahman","year":"2006","journal-title":"Eur Respir J"},{"issue":"652","key":"key20260915131015_b13-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00267-5","article-title":"Author Correction: Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"key20260915131015_b14-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"4398","DOI":"10.21037\/jtd.2017.09.135","article-title":"Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-\u03baB signaling pathway","volume":"9","author":"Wang","year":"2017","journal-title":"J Thorac Dis"},{"issue":"121658","key":"key20260915131015_b15-BR-25-4-02194","article-title":"Polyphenol-functionalized biosensors for real-time monitoring of oxidative stress and inflammation","volume":"235","author":"Chen","year":"2025","journal-title":"Ind Crops Prod"},{"issue":"102927","key":"key20260915131015_b16-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102927","article-title":"(Poly)phenols and the regulation of NADPH oxidases","volume":"67","author":"Fraga","year":"2023","journal-title":"Redox Biol"},{"key":"key20260915131015_b17-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"6999","DOI":"10.1039\/c9fo01733j","article-title":"In vivo formed metabolites of polyphenols and their biological efficacy","volume":"10","author":"Serreli","year":"2019","journal-title":"Food Funct"},{"key":"key20260915131015_b18-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.foodchem.2015.08.083","article-title":"In vitro and in vivo antioxidant activity of polyphenols extracted from black highland barley","volume":"194","author":"Shen","year":"2016","journal-title":"Food Chem"},{"issue":"e15551","key":"key20260915131015_b19-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15551","article-title":"Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response","volume":"9","author":"Kostenko","year":"2023","journal-title":"Heliyon"},{"issue":"429","key":"key20260915131015_b20-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040429","article-title":"Dietary polyphenols: Review on chemistry\/sources, bioavailability\/metabolism, antioxidant effects, and their role in disease management","volume":"13","author":"Rudrapal","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"63","key":"key20260915131015_b21-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010063","article-title":"Quercetin, epigallocatechin gallate, curcumin, and resveratrol: From dietary sources to human MicroRNA modulation","volume":"25","author":"Cione","year":"2019","journal-title":"Molecules"},{"issue":"100921","key":"key20260915131015_b22-BR-25-4-02194","article-title":"Recent advances in the effects of dietary polyphenols on inflammation in vivo: Potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers","volume":"48","author":"Wang","year":"2022","journal-title":"Curr Opin Food Sci"},{"key":"key20260915131015_b23-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.2147\/DDDT.S148868","article-title":"Resveratrol as a potential therapeutic drug for respiratory system diseases","volume":"11","author":"Zhu","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"key20260915131015_b24-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/MCO.0000000000000314","article-title":"Interactions of gut microbiota with dietary polyphenols and consequences to human health","volume":"19","author":"Tom\u00e1s-Barber\u00e1n","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"key20260915131015_b25-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.foodchem.2014.02.022","article-title":"Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health","volume":"157","author":"Denev","year":"2014","journal-title":"Food Chem"},{"key":"key20260915131015_b26-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"317S","DOI":"10.1093\/ajcn\/81.1.317S","article-title":"Polyphenols and disease risk in epidemiologic studies","volume":"81 (1 Suppl)","author":"Arts","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"1355","key":"key20260915131015_b27-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061355","article-title":"Systematic review on polyphenol intake and health outcomes: Is there sufficient evidence to define a health-promoting polyphenol-rich dietary pattern?","volume":"11","author":"Del Bo'","year":"2019","journal-title":"Nutrients"},{"key":"key20260915131015_b28-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81 (1 Suppl)","author":"Manach","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"key20260915131015_b29-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/ijms11041321","article-title":"Bioavailability of the polyphenols: Status and controversies","volume":"11","author":"D'Archivio","year":"2010","journal-title":"Int J Mol Sci"},{"issue":"3813","key":"key20260915131015_b30-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043813","article-title":"Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota","volume":"24","author":"Lippolis","year":"2023","journal-title":"Int J Mol Sci"},{"key":"key20260915131015_b31-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.7150\/ijbs.93875","article-title":"Polyphenols as therapeutics in respiratory diseases: Moving from preclinical evidence to potential clinical applications","volume":"20","author":"Emran","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"220028","key":"key20260915131015_b32-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0028-2022","article-title":"Polyphenols, flavonoids and inflammasomes: The role of cigarette smoke in COPD","volume":"31","author":"Fu","year":"2022","journal-title":"Eur Respir Rev"},{"issue":"87","key":"key20260915131015_b33-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00087","article-title":"The role of polyphenols in human health and food systems: A mini-review","volume":"5","author":"Cory","year":"2018","journal-title":"Front Nutr"},{"issue":"n71","key":"key20260915131015_b34-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"l4898","key":"key20260915131015_b35-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"key20260915131015_b36-BR-25-4-02194","author":"Higgins"},{"issue":"43","key":"key20260915131015_b37-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"key20260915131015_b38-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/sj.ejcn.1602309","article-title":"Pomegranate juice supplementation in chronic obstructive pulmonary disease: A 5-week randomized, double-blind, placebo-controlled trial","volume":"60","author":"Cerd\u00e1","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"key20260915131015_b39-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.phrs.2005.12.009","article-title":"Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats","volume":"53","author":"Iraz","year":"2006","journal-title":"Pharmacol Res"},{"issue":"131","key":"key20260915131015_b40-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-131","article-title":"Quercetin prevents progression of disease in elastase\/LPS-exposed mice by negatively regulating MMP expression","volume":"11","author":"Ganesan","year":"2010","journal-title":"Respir Res"},{"key":"key20260915131015_b41-BR-25-4-02194","doi-asserted-by":"crossref","first-page":"559","DOI":"10.5336\/medsci.2009-16060","article-title":"Comparison of anti-inflammatory effects of theopylline and resveratrolin in chronic bronchitic rats","volume":"31","author":"\u015eahi\u0307n","year":"2011","journal-title":"Turkiye Klinikleri J Med Sci"},{"key":"key20260915131015_b42-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/jbt.21447","article-title":"Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: A comparison with N-acetyl cysteine","volume":"26","author":"Hamdy","year":"2012","journal-title":"J Biochem Mol Toxicol"},{"key":"key20260915131015_b43-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.foodchem.2013.03.025","article-title":"Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy","volume":"141","author":"Flores","year":"2013","journal-title":"Food Chem"},{"key":"key20260915131015_b44-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3109\/19390211.2014.952865","article-title":"Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: A randomized controlled trial","volume":"13","author":"Panahi","year":"2016","journal-title":"J Diet Suppl"},{"key":"key20260915131015_b45-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1017\/S0007114515002597","article-title":"Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice","volume":"114","author":"Impellizzeri","year":"2015","journal-title":"Br J Nutr"},{"key":"key20260915131015_b46-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2016.09.001","article-title":"Curcumin ameliorates alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease","volume":"164","author":"Zhang","year":"2016","journal-title":"Life Sci"},{"issue":"1529","key":"key20260915131015_b47-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091529","article-title":"The effects of resveratrol on inflammation and oxidative stress in a rat model of chronic obstructive pulmonary disease","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"key20260915131015_b48-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"753","DOI":"10.21873\/invivo.11304","article-title":"Effect of oligomeric proanthocyanidin on the antioxidant status and lung function of patients with chronic obstructive pulmonary disease","volume":"32","author":"Lu","year":"2018","journal-title":"In Vivo"},{"issue":"e000392","key":"key20260915131015_b49-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2018-000392","article-title":"Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease","volume":"7","author":"Han","year":"2020","journal-title":"BMJ Open Respir Res"},{"key":"key20260915131015_b50-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s11010-020-03905-5","article-title":"Gallic acid ameliorates COPD-associated exacerbation in mice","volume":"476","author":"Singla","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"key20260915131015_b51-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.1080\/14786419.2021.1984909","article-title":"In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD)","volume":"36","author":"Coco","year":"2022","journal-title":"Nat Prod Res"},{"issue":"100264","key":"key20260915131015_b52-BR-25-4-02194","article-title":"Magnolol alleviates inflammation and oxidative stress in COPD via MAPK and Nrf2 signaling pathways","volume":"8","author":"Liu","year":"2024","journal-title":"Curr Res Biotechnol"},{"key":"key20260915131015_b53-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1002\/ptr.8114","article-title":"Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo-controlled clinical trial","volume":"38","author":"Zare'i","year":"2024","journal-title":"Phytother Res"},{"issue":"369","key":"key20260915131015_b54-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010369","article-title":"Luteolin alleviates oxidative stress in chronic obstructive pulmonary disease induced by cigarette smoke via modulation of the TRPV1 and CYP2A13\/NRF2 signaling pathways","volume":"25","author":"Zhou","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"107223","key":"key20260915131015_b55-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2025.107223","article-title":"Trehalose-stabilized micelle-in-microparticles of icariin targeting IL-4 pathway in chronic obstructive pulmonary disease","volume":"212","author":"Jiang","year":"2025","journal-title":"Eur J Pharm Sci"},{"issue":"103744","key":"key20260915131015_b56-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103744","article-title":"Gaylussacin, a stilbene glycoside, inhibits chronic obstructive pulmonary disease in mice","volume":"85","author":"Min","year":"2025","journal-title":"Redox Biol"},{"key":"key20260915131015_b57-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.2741\/4061","article-title":"The effects of dietary flavonoids on the regulation of redox inflammatory networks","volume":"17","author":"Izzi","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20260915131015_b58-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.2147\/COPD.S176122","article-title":"Role of inflammatory cells in airway remodeling in COPD","volume":"13","author":"Wang","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"839","key":"key20260915131015_b59-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14070839","article-title":"Oxidative stress and inflammation in hypoxemic respiratory diseases and their comorbidities: Molecular insights and diagnostic advances in chronic obstructive pulmonary disease and sleep apnea","volume":"14","author":"Rodr\u00edguez-P\u00e9rez","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"4273","key":"key20260915131015_b60-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124273","article-title":"The effects of fruit-derived polyphenols on cognition and lung function in healthy adults: A systematic review and meta-analysis","volume":"13","author":"Morton","year":"2021","journal-title":"Nutrients"},{"key":"key20260915131015_b61-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1002\/ptr.70268","article-title":"Redox paradox of polyphenols: Bioavailability, hormesis, and safety concerns","volume":"40","author":"Vrankova","year":"2026","journal-title":"Phytother Res"},{"issue":"809952","key":"key20260915131015_b62-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809952","article-title":"Dissecting the crosstalk between Nrf2 and NF-\u03baB response pathways in drug-induced toxicity","volume":"9","author":"Gao","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"key20260915131015_b63-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"key20260915131015_b64-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.mam.2018.08.001","article-title":"Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling","volume":"63","author":"Van Der Vliet","year":"2018","journal-title":"Mol Aspects Med"},{"issue":"115460","key":"key20260915131015_b65-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2025.115460","article-title":"Curcumin modulates the PTEN\/PI3K\/AKT pathway to alleviate inflammation and oxidative stress in PM2.5-induced chronic obstructive pulmonary disease","volume":"201","author":"Liu","year":"2025","journal-title":"Food Chem Toxicol"},{"issue":"1556868","key":"key20260915131015_b66-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1556868","article-title":"Airway remodeling in chronic obstructive pulmonary disease: Characteristics and opportunities","volume":"12","author":"Pan","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"key20260915131015_b67-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/S0140-6736(05)66456-2","article-title":"Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (bronchitis randomized on NAC cost-utility study, BRONCUS): A randomised placebo-controlled trial","volume":"365","author":"Decramer","year":"2005","journal-title":"Lancet"},{"issue":"1617694","key":"key20260915131015_b68-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1617694","article-title":"Efficacy and safety of dietary polyphenol supplements for COPD: A systematic review and meta-analysis","volume":"16","author":"Wu","year":"2025","journal-title":"Front Immunol"},{"issue":"92","key":"key20260915131015_b69-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-025-00844-0","article-title":"Emerging therapeutics in COPD: Mapping innovation to treatable traits","volume":"203","author":"Cazzola","year":"2025","journal-title":"Lung"},{"issue":"125633","key":"key20260915131015_b70-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125633","article-title":"Immediate and late systemic and lung effects of inhaled paraquat in rats","volume":"415","author":"Amin","year":"2021","journal-title":"J Hazard Mater"},{"issue":"25","key":"key20260915131015_b71-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1186\/s12971-017-0130-2","article-title":"Experimental animal models for COPD: A methodological review","volume":"15","author":"Ghorani","year":"2017","journal-title":"Tob Induc Dis"},{"issue":"108131","key":"key20260915131015_b72-BR-25-4-02194","article-title":"Emerging trends and advances in antioxidant-based plant derived nano formulations in alleviating lung diseases","volume":"119","author":"Narayanan","year":"2026","journal-title":"J Drug Deliv Sci Technol"},{"key":"key20260915131015_b73-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1055\/s-0043-1766117","article-title":"Global trends in occupational lung disease","volume":"44","author":"Cohen","year":"2023","journal-title":"Semin Respir Crit Care Med"},{"issue":"2416808","key":"key20260915131015_b74-BR-25-4-02194","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2024.03.004","article-title":"Issue 3-the occupational burden of respiratory diseases, an update","volume":"31","author":"Murgia","year":"2025","journal-title":"Pulmonology"},{"key":"key20260915131015_b75-BR-25-4-02194","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S2213-2600(16)30424-6","article-title":"Occupational lung diseases: From old and novel exposures to effective preventive strategies","volume":"5","author":"Cullinan","year":"2017","journal-title":"Lancet Respir Med"}],"container-title":["Biomedical Reports"],"original-title":[],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:10:22Z","timestamp":1789467022000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/br.2026.2194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.3892\/br.2026.2194","relation":{},"ISSN":["2049-9434","2049-9442"],"issn-type":[{"value":"2049-9434","type":"print"},{"value":"2049-9442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}