{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:39:54Z","timestamp":1791268794911,"version":"4.1.0"},"reference-count":28,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.3892\/etm.2014.1529","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T13:21:44Z","timestamp":1392038504000},"page":"935-940","source":"Crossref","is-referenced-by-count":26,"title":["M1\/M2 macrophages and associated mechanisms in congenital bicuspid aortic valve stenosis"],"prefix":"10.3892","volume":"7","author":[{"given":"RUI","family":"WANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHIFEI","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIANGPENG","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"key20180108124931_b1-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"key":"key20180108124931_b2-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community","volume":"117","author":"Michelena","year":"2008","journal-title":"Circulation"},{"key":"key20180108124931_b3-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/heart.88.4.321","article-title":"Calcification of bicuspid aortic valves","volume":"88","author":"Otto","year":"2002","journal-title":"Heart"},{"key":"key20180108124931_b4-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.yjmcc.2009.08.008","article-title":"Notch1 represses osteogenic pathways in aortic valve cells","volume":"47","author":"Nigam","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"key20180108124931_b5-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1016\/j.jbiomech.2008.08.006","article-title":"A multiscale computational comparison of the bicuspid and tricuspid aortic valves in relation to calcific aortic stenosis","volume":"41","author":"Weinberg","year":"2008","journal-title":"J Biomech"},{"key":"key20180108124931_b6-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jtcvs.2007.02.041","article-title":"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms","volume":"134","author":"McKellar","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key20180108124931_b7-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cellimm.2013.01.010","article-title":"Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin","volume":"281","author":"Jaguin","year":"2013","journal-title":"Cell Immunol"},{"key":"key20180108124931_b8-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbalip.2012.10.009","article-title":"Macrophage heterogeneity and cholesterol homeostasis: classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL","volume":"1831","author":"Chu","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key20180108124931_b9-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"key20180108124931_b10-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2407-10-112","article-title":"The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time","volume":"10","author":"Ma","year":"2010","journal-title":"BMC Cancer"},{"key":"key20180108124931_b11-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/MOL.0b013e3283309848","article-title":"Macrophage heterogeneity in atherosclerotic plaques","volume":"20","author":"Johnson","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"key20180108124931_b12-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key20180108124931_b13-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"e47045","DOI":"10.1371\/journal.pone.0047045","article-title":"The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer","volume":"7","author":"Edin","year":"2012","journal-title":"PLoS One"},{"key":"key20180108124931_b14-etm-07-04-0935","first-page":"673","article-title":"The expression of EGFR in oral lichen planus, squamous cell papilloma and squamous cell carcinoma","volume":"21","author":"Zhao","year":"2012","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"key20180108124931_b15-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jacc.2007.06.024","article-title":"Insights into degenerative aortic valve disease","volume":"50","author":"Goldbarg","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"key20180108124931_b16-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jtcvs.2008.10.045","article-title":"Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosis","volume":"138","author":"Yu","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key20180108124931_b17-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0046-8177(03)00245-4","article-title":"Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis","volume":"34","author":"Soini","year":"2003","journal-title":"Hum Pathol"},{"key":"key20180108124931_b18-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9149(70)90761-7","article-title":"The congenitally bicuspid aortic valve. A study of 85 autopsy cases","volume":"26","author":"Roberts","year":"1970","journal-title":"Am J Cardiol"},{"key":"key20180108124931_b19-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/01.CIR.44.2.272","article-title":"Congenital aortic stenosis resulting from a unicommisssural valve. Clinical and anatomic features in twenty-one adult patients","volume":"44","author":"Falcone","year":"1971","journal-title":"Circulation"},{"key":"key20180108124931_b20-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jtcvs.2011.03.002","article-title":"Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis","volume":"142","author":"Moreno","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key20180108124931_b21-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1003521","article-title":"Circulating activated and effector memory T cells are associated with calcification and clonal expansions in bicuspid and tricuspid valves of calcific aortic stenosis","volume":"187","author":"Winchester","year":"2011","journal-title":"J Immunol"},{"key":"key20180108124931_b22-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"key20180108124931_b23-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/ATVBAHA.113.301453","article-title":"Transcriptional control of macrophage polarization","volume":"33","author":"Tugal","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180108124931_b24-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"key20180108124931_b25-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.4049\/jimmunol.177.10.7303","article-title":"Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression","volume":"177","author":"Martinez","year":"2006","journal-title":"J Immunol"},{"key":"key20180108124931_b26-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cmet.2007.06.010","article-title":"PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties","volume":"6","author":"Bouhlel","year":"2007","journal-title":"Cell Metab"},{"key":"key20180108124931_b27-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.coi.2007.10.010","article-title":"Antigen presentation by monocytes and monocyte-derived cells","volume":"20","author":"Randolph","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"key20180108124931_b28-etm-07-04-0935","doi-asserted-by":"crossref","first-page":"685926","DOI":"10.4061\/2010\/685926","article-title":"Crystalline ultrastructures, inflammatory elements, and neoangiogenesis are present in inconspicuous aortic valve tissue","volume":"2010","author":"Dorfm\u00fcller","year":"2010","journal-title":"Cardiol Res Pract"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2014.1529\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T22:18:44Z","timestamp":1515449924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2014.1529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,2,10]]},"published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.3892\/etm.2014.1529"],"URL":"https:\/\/doi.org\/10.3892\/etm.2014.1529","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]}}}