{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:21:49Z","timestamp":1769325709053,"version":"3.49.0"},"reference-count":61,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.3892\/etm.2014.2163","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T09:54:17Z","timestamp":1419933257000},"page":"653-657","source":"Crossref","is-referenced-by-count":19,"title":["Pancreas \u03b2 cell regeneration and type 1 diabetes (Review)"],"prefix":"10.3892","volume":"9","author":[{"given":"JINXIAO","family":"WU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIYAN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BIN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIUPING","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"key20180108125534_b1-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tem.2010.09.004","article-title":"\u03b2-cell regeneration: the pancreatic intrinsic faculty","volume":"22","author":"Desgraz","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"key20180108125534_b2-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3892\/etm.2013.1403","article-title":"Pancreaticobiliary maljuction combining with pancreas divisum: report of four cases","volume":"7","author":"Zhang","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180108125534_b3-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1073\/pnas.0308604100","article-title":"Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development","volume":"101","author":"Prado","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b4-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3892\/etm.2013.1300","article-title":"Insulinization: a promising strategy for the treatment of type 2 diabetes mellitus","volume":"6","author":"Guo","year":"2013","journal-title":"Exp Ther Med"},{"key":"key20180108125534_b5-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/JME-10-0019","article-title":"Unraveling the role of the ghrelin gene peptides in the endocrine pancreas","volume":"45","author":"Granata","year":"2010","journal-title":"J Mol Endocrinol"},{"key":"key20180108125534_b6-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/EJE-09-1053","article-title":"Beta-cell development and turnover during prenatal life in humans","volume":"162","author":"Meier","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"key20180108125534_b7-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/JME-06-0053","article-title":"Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion","volume":"38","author":"Ackermann","year":"2007","journal-title":"J Mol Endocrinol"},{"key":"key20180108125534_b8-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/dev.02770","article-title":"Pancreas and beta-cell development: from the actual to the possible","volume":"134","author":"Murtaugh","year":"2007","journal-title":"Development"},{"key":"key20180108125534_b9-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000217832","article-title":"On the origin of pancreatic endocrine cells, proliferation and neoplastic transformation","volume":"14","author":"Teitelman","year":"1993","journal-title":"Tumour Biol"},{"key":"key20180108125534_b10-etm-09-03-0653","first-page":"2317","article-title":"Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages","volume":"127","author":"Herrera","year":"2000","journal-title":"Developmen"},{"key":"key20180108125534_b11-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0012-1606(72)90083-8","article-title":"An ultrastructural analysis of the developing embryonic pancreas","volume":"29","author":"Pictet","year":"1972","journal-title":"Dev Biol"},{"key":"key20180108125534_b12-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devcel.2007.06.001","article-title":"A multipotent progenitor domain guides pancreatic organogenesis","volume":"13","author":"Zhou","year":"2007","journal-title":"Dev Cell"},{"key":"key20180108125534_b13-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2007.02.010","article-title":"Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types","volume":"12","author":"Johansson","year":"2007","journal-title":"Dev Cell"},{"key":"key20180108125534_b14-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b15-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/978-1-4614-5441-0_23","article-title":"Beta-cell regeneration in human pancreas: the lessons of pancreatic pathology","volume":"771","author":"Maulis","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"key20180108125534_b16-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3892\/etm_00000062","article-title":"Expression and tissue distribution of human X-linked armadillo repeat containing-6","volume":"1","author":"Kusama","year":"2010","journal-title":"Exp Ther Med"},{"key":"key20180108125534_b17-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00268-004-7598-7","article-title":"Nesidioblastosis: an old term and a new understanding","volume":"28","author":"Kaczirek","year":"2004","journal-title":"World J Surg"},{"key":"key20180108125534_b18-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"key20180108125534_b19-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1371\/journal.pbio.0050163","article-title":"All beta cells contribute equally to islet growth and maintenance","volume":"5","author":"Brennand","year":"2007","journal-title":"PLoS Biol"},{"key":"key20180108125534_b20-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.devcel.2007.04.011","article-title":"Growth and regeneration of adult beta cells does not involve specialized progenitors","volume":"12","author":"Teta","year":"2007","journal-title":"Dev Cell"},{"key":"key20180108125534_b21-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1210\/endo.138.4.5069","article-title":"Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat","volume":"138","author":"Scaglia","year":"1997","journal-title":"Endocrinology"},{"key":"key20180108125534_b22-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2337\/diabetes.54.9.2557","article-title":"Very slow turnover of beta-cells in aged adult mice","volume":"54","author":"Teta","year":"2005","journal-title":"Diabetes"},{"key":"key20180108125534_b23-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.054304","article-title":"Glucose and aging control the quiescence period that follows pancreatic beta cell replication","volume":"137","author":"Salpeter","year":"2010","journal-title":"Development"},{"key":"key20180108125534_b24-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1210\/en.2002-220405","article-title":"Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats","volume":"143","author":"Farilla","year":"2002","journal-title":"Endocrinology"},{"key":"key20180108125534_b25-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature05092","article-title":"p16INK4a induces an age-dependent decline in islet regenerative potential","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"key20180108125534_b26-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tem.2009.11.001","article-title":"Expansion of beta-cell mass in response to pregnancy","volume":"21","author":"Rieck","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"key20180108125534_b27-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI22098","article-title":"Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass","volume":"114","author":"Georgia","year":"2004","journal-title":"J Clin Invest"},{"key":"key20180108125534_b28-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1128\/MCB.25.9.3752-3762.2005","article-title":"Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth","volume":"25","author":"Kushner","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180108125534_b29-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s00125-004-1372-0","article-title":"Pancreatic islets from cyclin-dependent kinase 4\/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes","volume":"47","author":"Marzo","year":"2004","journal-title":"Diabetologia"},{"key":"key20180108125534_b30-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4049\/jimmunol.180.2.1189","article-title":"Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model","volume":"180","author":"Marzo","year":"2008","journal-title":"J Immunol"},{"key":"key20180108125534_b31-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2337\/db09-1295","article-title":"Ectopic expression of E2F1 stimulates beta-cell proliferation and function","volume":"59","author":"Grouwels","year":"2010","journal-title":"Diabetes"},{"key":"key20180108125534_b32-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1073\/pnas.0408836102","article-title":"Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors","volume":"102","author":"Milne","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b33-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"14659","DOI":"10.1073\/pnas.0503484102","article-title":"Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c","volume":"102","author":"Karnik","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b34-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cell.2008.01.004","article-title":"Facultative endocrine progenitor cells in the adult pancreas","volume":"132","author":"Dor","year":"2008","journal-title":"Cell"},{"key":"key20180108125534_b35-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3892\/etm.2013.1366","article-title":"Evaluation of the revised versus the simplified scoring system in patients with autoimmune hepatitis","volume":"7","author":"Li","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180108125534_b36-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"19915","DOI":"10.1073\/pnas.0805803105","article-title":"Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth","volume":"105","author":"Inada","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b37-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.2337\/db10-0084","article-title":"Beta-cell growth and regeneration: replication is only part of the story","volume":"59","author":"Bonner-Weir","year":"2010","journal-title":"Diabetes"},{"key":"key20180108125534_b38-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1210\/jc.2005-1171","article-title":"Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies","volume":"91","author":"Gianani","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108125534_b39-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00125-008-1105-x","article-title":"Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity","volume":"51","author":"Martin-Pagola","year":"2008","journal-title":"Diabetologia"},{"key":"key20180108125534_b40-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1210\/en.2009-0992","article-title":"Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury","volume":"151","author":"Liu","year":"2010","journal-title":"Endocrinology"},{"key":"key20180108125534_b41-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bbrc.2004.12.120","article-title":"Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice","volume":"327","author":"Kodama","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108125534_b42-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"key20180108125534_b43-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/stem.482","article-title":"Pancreatic \u03b2-cell neogenesis by direct conversion from mature \u03b1-cells","volume":"28","author":"Chung","year":"2010","journal-title":"Stem Cells"},{"key":"key20180108125534_b44-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/intimm\/dxs049","article-title":"Inflammation and type one diabetes","volume":"24","author":"Bending","year":"2012","journal-title":"Int Immunol"},{"key":"key20180108125534_b45-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2009.05.035","article-title":"The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells","volume":"138","author":"Collombat","year":"2009","journal-title":"Cell"},{"key":"key20180108125534_b46-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1073\/pnas.0237106100","article-title":"Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice","volume":"100","author":"Gelling","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108125534_b47-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/bdrc.20156","article-title":"Pancreas cell fate","volume":"87","author":"Guney","year":"2009","journal-title":"Birth Defects Res C Embryo Today"},{"key":"key20180108125534_b48-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"e8653","DOI":"10.1371\/journal.pone.0008653","article-title":"Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass","volume":"5","author":"Lee","year":"2010","journal-title":"PLoS One"},{"key":"key20180108125534_b49-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00281-010-0205-0","article-title":"Immunopathology of the human pancreas in type-I diabetes","volume":"33","author":"Richardson","year":"2011","journal-title":"Semin Immunopathol"},{"key":"key20180108125534_b50-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s11892-011-0218-7","article-title":"Potential pathways to restore \u03b2-cell mass: pluripotent stem cells, reprogramming, and endogenous regeneration","volume":"11","author":"Baiu","year":"2011","journal-title":"Curr Diab Rep"},{"key":"key20180108125534_b51-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00125-009-1642-y","article-title":"Dimorphic histopathology of long-standing childhood-onset diabetes","volume":"53","author":"Gianani","year":"2010","journal-title":"Diabetologia"},{"key":"key20180108125534_b52-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1007\/s00125-005-1949-2","article-title":"Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?","volume":"48","author":"Meier","year":"2005","journal-title":"Diabetologia"},{"key":"key20180108125534_b53-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3892\/etm.2012.787","article-title":"Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus","volume":"5","author":"Liu","year":"2013","journal-title":"Exp Ther Med"},{"key":"key20180108125534_b54-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.4161\/cc.19679","article-title":"Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness","volume":"11","author":"Lonardo","year":"2012","journal-title":"Cell Cycle"},{"key":"key20180108125534_b55-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"329596","DOI":"10.1155\/2013\/329596","article-title":"Bone marrow stem cell as a potential treatment for diabetes","volume":"2013","author":"Li","year":"2013","journal-title":"J Diabetes Res"},{"key":"key20180108125534_b56-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.gassur.2003.09.008","article-title":"Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis","volume":"7","author":"Rodriguez Rilo","year":"2003","journal-title":"J Gastrointest Surg"},{"key":"key20180108125534_b57-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02938465","article-title":"Changes in microvascular structure of the fibrotic pancreas and their influence on pancreatic endocrine function","volume":"4","author":"Yatagai","year":"1989","journal-title":"Int J Pancreatol"},{"key":"key20180108125534_b58-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02739772","article-title":"Focal and Diffuse Beta Cell Changes in Persistent Hyperinsulinemic Hypoglycemia of Infancy","volume":"10","author":"Kl\u00f6ppel","year":"1999","journal-title":"Endocr Pathol"},{"key":"key20180108125534_b59-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"F108","DOI":"10.1136\/fn.82.2.F108","article-title":"Persistent hyperinsulinaemic hypoglycaemia of infancy: a heterogeneous syndrome unrelated to nesidioblastosis","volume":"82","author":"Rahier","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"key20180108125534_b60-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000207480","article-title":"Hyperinsulinism in developmental syndromes","volume":"14","author":"Kapoor","year":"2009","journal-title":"Endocr Dev"},{"key":"key20180108125534_b61-etm-09-03-0653","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/etm.2012.612","article-title":"Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases","volume":"4","author":"Bae","year":"2012","journal-title":"Exp Ther Med"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2014.2163\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T16:13:23Z","timestamp":1650903203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2014.2163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,12,30]]},"published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.3892\/etm.2014.2163"],"URL":"https:\/\/doi.org\/10.3892\/etm.2014.2163","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]}}}