{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:47Z","timestamp":1792067747790,"version":"4.4.0"},"reference-count":38,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.3892\/etm.2015.2658","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T08:50:56Z","timestamp":1437987056000},"page":"1437-1444","source":"Crossref","is-referenced-by-count":15,"title":["Role of matrix metalloproteinases in radiation-induced lung injury in alveolar epithelial cells of Bama minipigs"],"prefix":"10.3892","volume":"10","author":[{"given":"HAIYING","family":"YUE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAI","family":"HU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WENQI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIE","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUHUA","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RENSHENG","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"key20180108124107_b1-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1470-2045(03)01191-4","article-title":"Effects of radiation on normal tissue: Consequences and mechanisms","volume":"4","author":"Stone","year":"2003","journal-title":"Lancet Oncol"},{"key":"key20180108124107_b2-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.064","article-title":"New insights into the molecular pathology of radiation-induced pneumopathy","volume":"101","author":"Cappuccini","year":"2011","journal-title":"Radiother Oncol"},{"key":"key20180108124107_b3-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijrobp.2003.09.045","article-title":"Target cells in raditation pneumopathy","volume":"58","author":"Trott","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108124107_b4-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1073\/pnas.0605669103","article-title":"Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix","volume":"103","author":"Kim","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108124107_b5-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0002-9440(10)62351-6","article-title":"Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-\u03b21: Potential role in idiopathic pulmonary fibrosis","volume":"166","author":"Willis","year":"2005","journal-title":"Am J Pathol"},{"key":"key20180108124107_b6-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"key20180108124107_b7-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"e53628","DOI":"10.1371\/journal.pone.0053628","article-title":"The role of alveolar epithelium in radiation-induced lung injury","volume":"8","author":"Almeida","year":"2013","journal-title":"PLoS One"},{"key":"key20180108124107_b8-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1667\/RR1880.1","article-title":"Animal models for medical countermeasures to radiation exposure","volume":"173","author":"Williams","year":"2010","journal-title":"Radiat Res"},{"key":"key20180108124107_b9-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/095530000138439","article-title":"The pig as a model for the study of radiation effects on the lung","volume":"76","author":"Hopewell","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"key20180108124107_b10-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1748-717X-4-66","article-title":"Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model","volume":"4","author":"Li","year":"2009","journal-title":"Radiat Oncol"},{"key":"key20180108124107_b11-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1440-1843.2012.02247.x","article-title":"Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril","volume":"17","author":"Molthen","year":"2012","journal-title":"Respirology"},{"key":"key20180108124107_b12-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0360-3016(80)90145-5","article-title":"The sequence of histological changes in mouse lungs after single doses of x-rays","volume":"6","author":"Travis","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108124107_b13-etm-0-0-2658","first-page":"L1030","article-title":"Cell cycle kinetics in the alveolar epithelium","volume":"272","author":"Uhal","year":"1997","journal-title":"Am J Physiol"},{"key":"key20180108124107_b14-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"L129","DOI":"10.1152\/ajplung.00427.2002","article-title":"Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway","volume":"286","author":"Alcorn","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20180108124107_b15-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"L899","DOI":"10.1152\/ajplung.00082.2003","article-title":"Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells","volume":"285","author":"Vazquez de Lara","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20180108124107_b16-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/ajrccm\/141.4_Pt_1.998","article-title":"Changes in surfactant in bronchoalveolar lavage fluid after hemithorax irradiation in patients with mesothelioma","volume":"141","author":"Hallman","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"key20180108124107_b17-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0360-3016(00)01591-1","article-title":"Clinical significance of serum pulmonary surfactant proteins A and D for the early detection of radiation pneumonitis","volume":"50","author":"Sasaki","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108124107_b18-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"key20180108124107_b19-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J Exp Med"},{"key":"key20180108124107_b20-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.freeradbiomed.2011.11.024","article-title":"ERK\/GSK3\u03b2\/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition","volume":"52","author":"Nagarajan","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"key20180108124107_b21-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"Verrecchia","year":"2007","journal-title":"World J Gastroenterol"},{"key":"key20180108124107_b22-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.med.55.091902.103810","article-title":"Mechanisms of pulmonary fibrosis","volume":"55","author":"Thannickal","year":"2004","journal-title":"Annu Rev Med"},{"key":"key20180108124107_b23-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.lungcan.2007.08.010","article-title":"The predictive role of plasma TGF-\u03b21 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer","volume":"59","author":"Zhao","year":"2008","journal-title":"Lung Cancer"},{"key":"key20180108124107_b24-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ Res"},{"key":"key20180108124107_b25-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1165\/rcmb.2002-0166TR","article-title":"Matrix metalloproteinase-9 in lung remodeling","volume":"28","author":"Atkinson","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180108124107_b26-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","article-title":"Inflammation and EMT: An alliance towards organ fibrosis and cancer progression","volume":"1","author":"L\u00f3pez-Novoa","year":"2009","journal-title":"EMBO Mol Med"},{"key":"key20180108124107_b27-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2353\/ajpath.2010.090188","article-title":"Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells","volume":"176","author":"Tan","year":"2010","journal-title":"Am J Pathol"},{"key":"key20180108124107_b28-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0002-9440(10)64327-1","article-title":"Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation","volume":"162","author":"Cheng","year":"2003","journal-title":"Am J Pathol"},{"key":"key20180108124107_b29-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ijrobp.2010.12.032","article-title":"Irradiation alters MMP-2\/TIMP-2 system and collagen type IV degradation in brain","volume":"82","author":"Lee","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108124107_b30-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.3748\/wjg.v11.i40.6312","article-title":"Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells","volume":"11","author":"StrupPerrot","year":"2005","journal-title":"World J Gastroenterol"},{"key":"key20180108124107_b31-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/09553000701558977","article-title":"Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury","volume":"83","author":"Yang","year":"2007","journal-title":"Int J Radiat Biol"},{"key":"key20180108124107_b32-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0360-3016(03)00161-5","article-title":"Increased plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung and breast cancer are altered during chest radiotherapy","volume":"56","author":"Susskind","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108124107_b33-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/jcs.006064","article-title":"Extracellular matrix dynamics in development and regenerative medicine","volume":"121","author":"Daley","year":"2008","journal-title":"J Cell Sci"},{"key":"key20180108124107_b34-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/rcmb.2007-0071OC","article-title":"Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-\u03b2 signaling","volume":"38","author":"Shintani","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180108124107_b35-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0002-9440(10)62518-7","article-title":"Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation","volume":"159","author":"Zeisberg","year":"2001","journal-title":"Am J Pathol"},{"key":"key20180108124107_b36-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.nano.2011.06.021","article-title":"Cytoskeletal re-arrangement in TGF-\u03b21-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis","volume":"8","author":"Buckley","year":"2012","journal-title":"Nanomedicine (Lond)"},{"key":"key20180108124107_b37-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"L1327","DOI":"10.1152\/ajplung.2001.280.6.L1327","article-title":"Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung","volume":"280","author":"Kolb","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20180108124107_b38-etm-0-0-2658","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1465-9921-6-56","article-title":"TGF-\u03b21 induces human alveolar epithelial to mesenchymal cell transition (EMT)","volume":"6","author":"Kasai","year":"2005","journal-title":"Respir Res"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2015.2658\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T21:55:25Z","timestamp":1515448525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2015.2658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,27]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,7,27]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.3892\/etm.2015.2658"],"URL":"https:\/\/doi.org\/10.3892\/etm.2015.2658","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,27]]}}}