{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:03:52Z","timestamp":1783404232587,"version":"3.54.6"},"reference-count":26,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.3892\/etm.2016.3384","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T11:50:50Z","timestamp":1464090650000},"page":"573-580","source":"Crossref","is-referenced-by-count":12,"title":["Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers"],"prefix":"10.3892","volume":"12","author":[{"given":"Jae Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Youn","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Ji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Soon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Keum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Seok","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Tae","family":"Jeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Ho","family":"Um","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Duck","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Sang","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donggeun","family":"Sul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon Jai","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"key20180108133225_b1-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1254\/jjp.72.183","article-title":"Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats","volume":"72","author":"Hori","year":"1996","journal-title":"Jpn J Pharmacol"},{"key":"key20180108133225_b2-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-2999(89)90324-5","article-title":"The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation","volume":"174","author":"Pique","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"key20180108133225_b3-etm-0-0-3384","first-page":"G341","article-title":"Endothelial nitric oxide synthase modulates gastric ulcer healing in rats: Am J Physiol Gastrointest","volume":"279","author":"Ma","year":"2000","journal-title":"Liver Physiol"},{"key":"key20180108133225_b4-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/jpet.106.105932","article-title":"Prostaglandin\/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury","volume":"319","author":"Brzozowski","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key20180108133225_b5-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"BR196","DOI":"10.12659\/MSM.881897","article-title":"Administration of obestatin accelerates the healing of chronic gastric ulcers in rats","volume":"17","author":"Dembi\u0144ski","year":"2011","journal-title":"Med Sci Monit"},{"key":"key20180108133225_b6-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","article-title":"A method for experimental, penetrating gastric and duodenal ulcers in rats. Observations on normal healing","volume":"16","author":"Okabe","year":"1971","journal-title":"Am J Dig Dis"},{"key":"key20180108133225_b7-etm-0-0-3384","doi-asserted-by":"crossref","DOI":"10.1002\/0471140856.tx2102s43","article-title":"Methods to measure gastric mucosal lesions in the rat","volume":"21","author":"Morini","year":"2010","journal-title":"Curr Protoc Toxicol"},{"issue":"Suppl 1","key":"key20180108133225_b8-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/00004836-199700001-00009","article-title":"Mechanism of gastric hyperemic response during acid secretion in rats: Relation to nitric oxide, prostaglandins, and sensory neurons","volume":"25","author":"Kato","year":"1997","journal-title":"J Clin Gastroenterol"},{"key":"key20180108133225_b9-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: Physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"key20180108133225_b10-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000201214","article-title":"Role of nitric oxide in the digestive system","volume":"56","author":"Konturek","year":"1995","journal-title":"Digestion"},{"key":"key20180108133225_b11-etm-0-0-3384","first-page":"611","article-title":"Central and peripheral neural aspects of gastroprotective and ulcer healing effects of lipopolysaccharides","volume":"52","author":"Konturek","year":"2001","journal-title":"J Physiol Pharmacol"},{"key":"key20180108133225_b12-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1034\/j.1600-079x.2002.1o811.x","article-title":"Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan","volume":"32","author":"Brzozowska","year":"2002","journal-title":"J Pineal Res"},{"key":"key20180108133225_b13-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1055\/s-2004-835843","article-title":"Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats","volume":"70","author":"Guo","year":"2004","journal-title":"Planta Med"},{"key":"key20180108133225_b14-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/s10620-009-0828-y","article-title":"Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells","volume":"55","author":"Cho","year":"2010","journal-title":"Dig Dis Sci"},{"key":"key20180108133225_b15-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(00)00278-8","article-title":"Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide-dependent mechanism in rats","volume":"399","author":"Li","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"key20180108133225_b16-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/gast.1997.v112.pm9041266","article-title":"Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation","volume":"112","author":"McCafferty","year":"1997","journal-title":"Gastroenterology"},{"key":"key20180108133225_b17-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ddr.430360103","article-title":"Nitric oxide-associated vasorelaxing effect of an anti-ulcer agent, benexate hydrochloride betadex","volume":"36","author":"Iwasaki","year":"1995","journal-title":"Drug Dev Res"},{"key":"key20180108133225_b18-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0024-3205(96)00413-4","article-title":"Inhibition of constitutive nitric oxide synthase by benexate","volume":"59","author":"Arimoto","year":"1996","journal-title":"Life Sci"},{"key":"key20180108133225_b19-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","article-title":"NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"key20180108133225_b20-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2036.16.s2.22.x","article-title":"Up-regulation of COX-2 by inhibition of COX-1 in the rat: A key to NSAID-induced gastric injury","volume":"16","author":"Tanaka","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180108133225_b21-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0928-4257(01)00005-5","article-title":"Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs","volume":"95","author":"Tanaka","year":"2001","journal-title":"J Physiol Paris"},{"key":"key20180108133225_b22-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1007\/s10620-005-2809-0","article-title":"Gastroprotective agent rebamipide induces cyclooxygenease-2 (COX-2) in gastric epithelial cells","volume":"50","author":"Murata","year":"2005","journal-title":"Dig Dis Sci"},{"issue":"Suppl 1","key":"key20180108133225_b23-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1007\/s10620-005-2802-7","article-title":"The role of cyclooxygenase in gastric mucosal protection","volume":"50","author":"Gudis","year":"2005","journal-title":"Dig Dis Sci"},{"key":"key20180108133225_b24-etm-0-0-3384","first-page":"773","article-title":"Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor","volume":"55","author":"Brzozowska","year":"2004","journal-title":"J Physiol Pharmacol"},{"key":"key20180108133225_b25-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.intimp.2004.10.005","article-title":"COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions","volume":"5","author":"Motilva","year":"2005","journal-title":"Int Immunopharmacol"},{"key":"key20180108133225_b26-etm-0-0-3384","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s10620-008-0577-3","article-title":"Effect of rebamipide on quality of peptic ulcer healing in rat","volume":"54","author":"Qi","year":"2009","journal-title":"Dig Dis Sci"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3384\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:09:44Z","timestamp":1748977784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,5,24]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.3892\/etm.2016.3384"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3384","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}