{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:01:12Z","timestamp":1790715672697,"version":"4.1.0"},"reference-count":43,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/etm.2016.3628","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T12:49:20Z","timestamp":1472474960000},"page":"2400-2404","source":"Crossref","is-referenced-by-count":22,"title":["Neurological teratogenic effects of antiepileptic drugs during pregnancy"],"prefix":"10.3892","volume":"12","author":[{"given":"Qingmei","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"key20180108132545_b1-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1528-1157.2003.t01-1-44703.x-i1","article-title":"Clinical care of pregnant women with epilepsy: neural tube defects and folic acid supplementation","volume":"44","author":"Yerby","year":"2003","journal-title":"Epilepsia"},{"key":"key20180108132545_b2-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm1074","article-title":"The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions","volume":"10","author":"Rogawski","year":"2004","journal-title":"Nat Med"},{"key":"key20180108132545_b3-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/jnnp.46.8.751","article-title":"Change of seizure frequency in pregnant epileptic women","volume":"46","author":"Schmidt","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20180108132545_b4-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1528-1167.2005.00323.x","article-title":"Best practice guidelines for the management of women with epilepsy","volume":"46","author":"Crawford","year":"2005","journal-title":"Epilepsia"},{"key":"key20180108132545_b5-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yebeh.2007.08.009","article-title":"Cognitive\/behavioral teratogenetic effects of antiepileptic drugs","volume":"11","author":"Meador","year":"2007","journal-title":"Epilepsy Behav"},{"key":"key20180108132545_b6-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1136\/jnnp.2003.029132","article-title":"The longer term outcome of children born to mothers with epilepsy","volume":"75","author":"Adab","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20180108132545_b7-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2008.04.022","article-title":"Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts","volume":"81","author":"Meador","year":"2008","journal-title":"Epilepsy Res"},{"key":"key20180108132545_b8-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"EUROCAT Antiepileptic Study Working Group: Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N Engl J Med"},{"key":"key20180108132545_b9-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jnnp.2005.074203","article-title":"Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register","volume":"77","author":"Morrow","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20180108132545_b10-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.1997.tb01480.x","article-title":"Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy","volume":"38","author":"Samr\u00e9n","year":"1997","journal-title":"Epilepsia"},{"key":"key20180108132545_b11-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1212\/01.WNL.0000154514.82948.69","article-title":"Liverpool and Manchester Neurodevelopment Study Group: Neuropsychological effects of exposure to anticonvulsant medication in utero","volume":"64","author":"Vinten","year":"2005","journal-title":"Neurology"},{"key":"key20180108132545_b12-etm-0-0-3628","first-page":"60","article-title":"Pregnancy in women with epilepsy: preliminary results of Kerala registry of epilepsy and pregnancy","volume":"49","author":"Thomas","year":"2001","journal-title":"Neurol India"},{"key":"key20180108132545_b13-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1212\/WNL.0000000000001182","article-title":"Liverpool and Manchester Neurodevelopment Group: IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study","volume":"84","author":"Baker","year":"2015","journal-title":"Neurology"},{"key":"key20180108132545_b14-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.yebeh.2009.09.024","article-title":"A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy","volume":"16","author":"McVearry","year":"2009","journal-title":"Epilepsy Behav"},{"key":"key20180108132545_b15-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1212\/WNL.62.1.28","article-title":"Normal intelligence in children with prenatal exposure to carbamazepine","volume":"62","author":"Gaily","year":"2004","journal-title":"Neurology"},{"key":"key20180108132545_b16-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1586\/ern.10.57","article-title":"Teratogenic effects of antiepileptic drugs","volume":"10","author":"Hill","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"key20180108132545_b17-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"key20180108132545_b18-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/tera.1420100212","article-title":"Induction of cleft palate in mice by tranquilizers and barbiturates","volume":"10","author":"Walker","year":"1974","journal-title":"Teratology"},{"key":"key20180108132545_b19-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.reprotox.2006.03.014","article-title":"Neuroteratogens in man: an overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy","volume":"22","author":"Ornoy","year":"2006","journal-title":"Reprod Toxicol"},{"key":"key20180108132545_b20-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2174\/1381612013397717","article-title":"Delayed developmental effects following prenatal exposure to drugs","volume":"7","author":"Mantovani","year":"2001","journal-title":"Curr Pharm Des"},{"key":"key20180108132545_b21-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/ajmg.a.35438","article-title":"Antiepileptic drugs and pregnancy outcomes","volume":"158A","author":"Wlodarczyk","year":"2012","journal-title":"Am J Med Genet A"},{"key":"key20180108132545_b22-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archneur.1979.00500430023002","article-title":"Valproic acid. Review of a new antiepileptic drug","volume":"36","author":"Bruni","year":"1979","journal-title":"Arch Neurol"},{"key":"key20180108132545_b23-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0887-2333(93)90111-H","article-title":"Effects of the anticonvulsant drug valproic acid and related substances on the early development of the zebrafish (Brachydanio rerio)","volume":"7","author":"Herrmann","year":"1993","journal-title":"Toxicol In Vitro"},{"key":"key20180108132545_b24-etm-0-0-3628","first-page":"127","article-title":"Effect of antiepileptic drugs valproic acid, carbamazepine and ethosuccimide on exploratory behaviour in mice","volume":"29","author":"Rao","year":"1991","journal-title":"Indian J Exp Biol"},{"key":"key20180108132545_b25-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/sj.bjp.0706830","article-title":"The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver","volume":"149","author":"Eyal","year":"2006","journal-title":"Br J Pharmacol"},{"key":"key20180108132545_b26-etm-0-0-3628","first-page":"955","article-title":"Teratogenic action of antiepileptic drug: 2-Propylpentanoic acid-effects on rat and hamster embryos cultured in vitro","volume":"72","author":"Wlodarczyk","year":"2001","journal-title":"Ginekol Pol"},{"key":"key20180108132545_b27-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/hmg\/9.2.227","article-title":"A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression","volume":"9","author":"Faiella","year":"2000","journal-title":"Hum Mol Genet"},{"key":"key20180108132545_b28-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.1320190308","article-title":"The fetal valproate syndrome","volume":"19","author":"DiLiberti","year":"1984","journal-title":"Am J Med Genet"},{"key":"key20180108132545_b29-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod Toxicol"},{"key":"key20180108132545_b30-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1212\/WNL.57.2.321","article-title":"Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies","volume":"57","author":"Diav-Citrin","year":"2001","journal-title":"Neurology"},{"key":"key20180108132545_b31-etm-0-0-3628","volume-title":"The use of psychotropic medications during pregnancy and lactation","author":"Harding","year":"1999"},{"key":"key20180108132545_b32-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM200104123441504","article-title":"The teratogenicity of anticonvulsant drugs","volume":"344","author":"Holmes","year":"2001","journal-title":"N Engl J Med"},{"key":"key20180108132545_b33-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1212\/01.WNL.0000154515.94346.89","article-title":"International Lamotrigine Pregnancy Registry Scientific Advisory Committee: Lamotrigine and the risk of malformations in pregnancy","volume":"64","author":"Cunnington","year":"2005","journal-title":"Neurology"},{"key":"key20180108132545_b34-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1046\/j.1528-1157.2002.45901.x","article-title":"International Lamotrigine Pregnancy Registry Scientific Advisory Committee: Preliminary results on pregnancy outcomes in women using lamotrigine","volume":"43","author":"Tennis","year":"2002","journal-title":"Epilepsia"},{"key":"key20180108132545_b35-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.1980.03310130042027","article-title":"Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate","volume":"244","author":"Allen","year":"1980","journal-title":"JAMA"},{"key":"key20180108132545_b36-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0892-0362(90)90092-Q","article-title":"Developmental neurotoxicity of anticonvulsants: human and animal evidence on phenytoin","volume":"12","author":"Adams","year":"1990","journal-title":"Neurotoxicol Teratol"},{"key":"key20180108132545_b37-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1212\/01.wnl.0000318293.28278.33","article-title":"UK Epilepsy and Pregnancy Register: Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register","volume":"71","author":"Hunt","year":"2008","journal-title":"Neurology"},{"key":"key20180108132545_b38-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1111\/j.1528-1157.1994.tb05952.x","article-title":"Teratogenic effects of antiepileptic drugs: implications for the management of epilepsy in women of childbearing age","volume":"35","author":"Lindhout","year":"1994","journal-title":"Epilepsia"},{"key":"key20180108132545_b39-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/bdra.23357","article-title":"Topiramate use during pregnancy and major congenital malformations in multiple populations","volume":"103","author":"Tennis","year":"2015","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key20180108132545_b40-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1526-4610.2012.02190.x","article-title":"Utilization of topiramate during pregnancy and risk of birth defects","volume":"52","author":"Green","year":"2012","journal-title":"Headache"},{"key":"key20180108132545_b41-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10072-005-0441-6","article-title":"Maternal exposure to the antiepileptic drug vigabatrin affects postnatal development in the rat","volume":"26","author":"Lombardo","year":"2005","journal-title":"Neurol Sci"},{"key":"key20180108132545_b42-etm-0-0-3628","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1528-1157.2002.26601.x","article-title":"Is there an association between maternal carbamazepine use during pregnancy and eye malformations in the child?","volume":"43","author":"Kroes","year":"2002","journal-title":"Epilepsia"},{"key":"key20180108132545_b43-etm-0-0-3628","first-page":"25","article-title":"Vigabatrin in pediatric patients with refractory epilepsy","volume":"48","author":"Turanli","year":"2006","journal-title":"Turk J Pediatr"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3628\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T23:24:14Z","timestamp":1515453854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,29]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/etm.2016.3628"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3628","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]}}}