{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:47:08Z","timestamp":1774360028745,"version":"3.50.1"},"reference-count":29,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/etm.2016.3629","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T07:00:03Z","timestamp":1472540403000},"page":"2702-2708","source":"Crossref","is-referenced-by-count":23,"title":["Astragaloside IV ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin D3-upregulated protein 1\/NF-\u03baB signaling pathway"],"prefix":"10.3892","volume":"12","author":[{"given":"Zhiyong","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"key20180108132615_b1-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.sempedsurg.2013.01.006","article-title":"Probiotics and the mechanism of necrotizing enterocolitis","volume":"22","author":"Chen","year":"2013","journal-title":"Semin Pediatr Surg"},{"key":"key20180108132615_b2-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"e17776","DOI":"10.1371\/journal.pone.0017776","article-title":"The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: An immature innate immune response","volume":"6","author":"Nanthakumar","year":"2011","journal-title":"PLoS One"},{"key":"key20180108132615_b3-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3748\/wjg.14.2142","article-title":"Necrotizing enterocolitis: A multifactorial disease with no cure","volume":"14","author":"Schnabl","year":"2008","journal-title":"World J Gastroenterol"},{"key":"key20180108132615_b4-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1055-8586(00)70018-7","article-title":"Necrotizing enterocolitis in infants with very low birth weight","volume":"9","author":"Chandler","year":"2000","journal-title":"Semin Pediatr Surg"},{"key":"key20180108132615_b5-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1346-8138.2006.00156.x","article-title":"Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases","volume":"33","author":"Chung","year":"2006","journal-title":"J Dermatol"},{"key":"key20180108132615_b6-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s10753-015-0110-8","article-title":"Antiasthmatic effects of eugenol in a mouse model of allergic asthma by regulation of vitamin D3 upregulated protein 1\/NF-\u03baB pathway","volume":"38","author":"Pan","year":"2015","journal-title":"Inflammation"},{"key":"key20180108132615_b7-etm-0-0-3629","first-page":"345","article-title":"Diverse functions of VDUP1 in cell proliferation, differentiation and diseases","volume":"4","author":"Kim","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"key20180108132615_b8-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molmed.2003.10.007","article-title":"Inflammation meets oxidation: NF-\u03baB as a mediator of initial lesion development in atherosclerosis","volume":"9","author":"Kutuk","year":"2003","journal-title":"Trends Mol Med"},{"key":"key20180108132615_b9-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2014.08.028","article-title":"Pathogenesis of necrotizing enterocolitis: Modeling the innate immune response","volume":"185","author":"Tanner","year":"2015","journal-title":"Am J Pathol"},{"key":"key20180108132615_b10-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3923\/ijp.2013.245.250","article-title":"A review on the role of oxidative stress and inflammation in necrotizing enterocolitis and benefits of the phosphodiesterase inhibitor pentoxifylline","volume":"9","author":"Shilan","year":"2013","journal-title":"International Journal of Pharmacology"},{"key":"key20180108132615_b11-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.semperi.2008.01.001","article-title":"The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis","volume":"32","author":"Frost","year":"2008","journal-title":"Semin Perinatol"},{"key":"key20180108132615_b12-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/0189-6725.109381","article-title":"The role of nitric oxide in an experimental necrotising enterocolitis model","volume":"10","author":"Cevik","year":"2013","journal-title":"Afr J Paediatr Surg"},{"key":"key20180108132615_b13-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"e76495","DOI":"10.1371\/journal.pone.0076495","article-title":"Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"key20180108132615_b14-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ptr.4759","article-title":"Isolation of anti-inflammatory fractions and compounds from the root of Astragalus membranaceus","volume":"27","author":"Lai","year":"2013","journal-title":"Phytother Res"},{"key":"key20180108132615_b15-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0254-6272(13)60189-2","article-title":"Pharmacological effects of Astragaloside IV: A literature review","volume":"33","author":"Ren","year":"2013","journal-title":"J Tradit Chin Med"},{"key":"key20180108132615_b16-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3892\/etm.2014.1905","article-title":"Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling","volume":"8","author":"Chen","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180108132615_b17-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/MPG.0b013e3182a7e02b","article-title":"Effects of boric acid and 2-aminoethoxydiphenyl borate on necrotizing enterocolitis","volume":"58","author":"Yaz\u0131c\u0131","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"key20180108132615_b18-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0254-6272(15)30140-0","article-title":"Effect of salvianolic acid A and C compatibility on inflammatory cytokines in rats with unilateral ureteral obstruction","volume":"35","author":"Li","year":"2015","journal-title":"J Tradit Chin Med"},{"key":"key20180108132615_b19-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/jsre.2000.5877","article-title":"Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis","volume":"92","author":"Nadler","year":"2000","journal-title":"J Surg Res"},{"key":"key20180108132615_b20-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0160-5402(90)90013-B","article-title":"Assessment of myeloperoxidase activity in whole rat kidney","volume":"24","author":"Hillegass","year":"1990","journal-title":"J Pharmacol Methods"},{"key":"key20180108132615_b21-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1039\/C4RA10756J","article-title":"Effects of luteolin on retinal oxidative stress and inflammation in diabetes","volume":"5","author":"Lu","year":"2015","journal-title":"RSC Advances"},{"key":"key20180108132615_b22-etm-0-0-3629","first-page":"244","article-title":"Induced expression of mRNA for IL-5, IL-6, TNF-alpha, MIP-2 and IFN-gamma in immunologically activated rat peritoneal mast cells: Inhibition by dexamethasone and cyclosporin A","volume":"86","author":"Williams","year":"1995","journal-title":"Immunology"},{"key":"key20180108132615_b23-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108132615_b24-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.injury.2011.02.011","article-title":"Second hit phenomenon: Existing evidence of clinical implications","volume":"42","author":"Lasanianos","year":"2011","journal-title":"Injury"},{"key":"key20180108132615_b25-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3892\/etm.2016.3199","article-title":"Study on the inflammatory intervention of erythropoietin on NEC","volume":"11","author":"Qi","year":"2016","journal-title":"Exp Ther Med Jun"},{"key":"key20180108132615_b26-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.jpedsurg.2015.07.009","article-title":"Bloodstream infections during the onset of necrotizing enterocolitis and their relation with the pro-inflammatory response, gut wall integrity and severity of disease in NEC","volume":"50","author":"Heida","year":"2015","journal-title":"J Pediatr Surg"},{"key":"key20180108132615_b27-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/cei.12431","article-title":"Rice prolamin extract ameliorates acute murine colitis by inhibiting nuclear factor-kappaB and modulating intestinal apoptosis and cell proliferation","volume":"178","author":"Chung","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"key20180108132615_b28-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1038\/ncomms6648","article-title":"Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status","volume":"5","author":"Everard","year":"2014","journal-title":"Nat Commun"},{"key":"key20180108132615_b29-etm-0-0-3629","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ptr.5297","article-title":"Astragaloside IV attenuates injury caused by myocardial ischemia\/reperfusion in rats via regulation of toll-like receptor 4\/nuclear factor-\u03baB signaling pathway","volume":"29","author":"Lu","year":"2015","journal-title":"Phytother Res"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3629\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T23:25:42Z","timestamp":1515453942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,30]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/etm.2016.3629"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3629","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}