{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:16:45Z","timestamp":1784571405177,"version":"3.55.0"},"reference-count":33,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/etm.2016.3640","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T13:02:21Z","timestamp":1472648541000},"page":"2537-2543","source":"Crossref","is-referenced-by-count":41,"title":["LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-\u03b21 signaling activity following subarachnoid hemorrhage in rats"],"prefix":"10.3892","volume":"12","author":[{"given":"Fan","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauthar","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"key20180108132720_b1-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12975-013-0257-2","article-title":"Early brain injury, an evolving frontier in subarachnoid hemorrhage research","volume":"4","author":"Fujii","year":"2013","journal-title":"Transl Stroke Res"},{"key":"key20180108132720_b2-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3171\/2012.3.JNS11706","article-title":"Timing of clinical grade assessment and poor outcome in patients with aneurysmal subarachnoid hemorrhage","volume":"117","author":"Giraldo","year":"2012","journal-title":"J Neurosurg"},{"key":"key20180108132720_b3-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.wneu.2013.01.110","article-title":"Pathophysiology of acute hydrocephalus after subarachnoid hemorrhage","volume":"80","author":"Shah","year":"2013","journal-title":"World Neurosurg"},{"key":"key20180108132720_b4-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1093\/brain\/awt203","article-title":"Decorin prevents the development of juvenile communicating hydrocephalus","volume":"136","author":"Botfield","year":"2013","journal-title":"Brain"},{"key":"key20180108132720_b5-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01401939","article-title":"Effect of antifibrinolytic therapy on subarachnoid fibrosis in dogs after experimental subarachnoid haemorrhage","volume":"54","author":"Ishii","year":"1980","journal-title":"Acta Neurochir (Wien)"},{"key":"key20180108132720_b6-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1001\/archneur.1989.00520430038014","article-title":"Factors associated with hydrocephalus after subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study","volume":"46","author":"Graff-Radford","year":"1989","journal-title":"Arch Neurol"},{"key":"key20180108132720_b7-etm-0-0-3640","first-page":"382","article-title":"Association of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage with transforming growth factor-\u03b21 levels and other risk factors","volume":"33","author":"Liu","year":"2013","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"key20180108132720_b8-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3892\/ijmm.2013.1253","article-title":"Thrombin-induced TGF-\u03b21 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage","volume":"31","author":"Li","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20180108132720_b9-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jnnp.2008.155671","article-title":"High CSF transforming growth factor beta levels after subarachnoid haemorrhage: Association with chronic communicating hydrocephalus","volume":"80","author":"Douglas","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20180108132720_b10-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.274.19.13586","article-title":"The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta","volume":"274","author":"Ribeiro","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180108132720_b11-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/bjs.9765","article-title":"Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor \u03b2 signal activation and liver regeneration after hepatectomy in an experimental model","volume":"102","author":"Kuroki","year":"2015","journal-title":"Br J Surg"},{"key":"key20180108132720_b12-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12272-010-0213-6","article-title":"LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction","volume":"33","author":"Xie","year":"2010","journal-title":"Arch Pharm Res"},{"key":"key20180108132720_b13-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0168-8278(03)00377-5","article-title":"A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo","volume":"39","author":"Kondou","year":"2003","journal-title":"J Hepatol"},{"key":"key20180108132720_b14-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s12035-014-8939-7","article-title":"Possible role of raf-1 kinase in the development of cerebral vasospasm and early brain injury after experimental subarachnoid hemorrhage in rats","volume":"52","author":"Zhang","year":"2015","journal-title":"Mol Neurobiol"},{"key":"key20180108132720_b15-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","article-title":"A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model","volume":"167","author":"Sugawara","year":"2008","journal-title":"J Neurosci Methods"},{"key":"key20180108132720_b16-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.brainres.2015.11.004","article-title":"Decorin alleviated chronic hydrocephalus via inhibiting TGF-\u03b21\/Smad\/CTGF pathway after subarachnoid hemorrhage in rats","volume":"1630","author":"Yan","year":"2016","journal-title":"Brain Res"},{"key":"key20180108132720_b17-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.expneurol.2015.04.016","article-title":"MFGE8\/Integrin \u03b23 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats","volume":"272","author":"Liu","year":"2015","journal-title":"Exp Neurol"},{"key":"key20180108132720_b18-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1161\/STROKEAHA.114.006635","article-title":"Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin \u03b23\/nuclear factor erythroid 2-related factor 2\/heme oxygenase pathway in subarachnoid hemorrhage rats","volume":"45","author":"Liu","year":"2014","journal-title":"Stroke"},{"key":"key20180108132720_b19-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/STROKEAHA.114.005116","article-title":"Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species\/hypoxia-inducible factor-1\u03b1\/\u03b2-catenin pathway in middle cerebral artery occlusion rats","volume":"45","author":"Hu","year":"2014","journal-title":"Stroke"},{"key":"key20180108132720_b20-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/STROKEAHA.112.662312","article-title":"Subarachnoid hemorrhage-induced hydrocephalus in rats","volume":"44","author":"Okubo","year":"2013","journal-title":"Stroke"},{"key":"key20180108132720_b21-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2015.01.005","article-title":"Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats","volume":"588","author":"Chen","year":"2015","journal-title":"Neurosci Lett"},{"key":"key20180108132720_b22-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/STROKEAHA.114.007265","article-title":"Norrin protected blood-brain barrier via frizzled-4\/\u03b2-catenin pathway after subarachnoid hemorrhage in rats","volume":"46","author":"Chen","year":"2015","journal-title":"Stroke"},{"key":"key20180108132720_b23-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pneurobio.2012.02.003","article-title":"The importance of early brain injury after subarachnoid hemorrhage","volume":"97","author":"Sehba","year":"2012","journal-title":"Prog Neurobiol"},{"key":"key20180108132720_b24-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2013.246","article-title":"Delayed neurological deterioration after subarachnoid haemorrhage","volume":"10","author":"Macdonald","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"key20180108132720_b25-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pneurobio.2013.09.002","article-title":"Controversies and evolving new mechanisms in subarachnoid hemorrhage","volume":"115","author":"Chen","year":"2014","journal-title":"Prog Neurobiol"},{"key":"key20180108132720_b26-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"e69571","DOI":"10.1371\/journal.pone.0069571","article-title":"Chronic hydrocephalus after experimental subarachnoid hemorrhage","volume":"8","author":"Lackner","year":"2013","journal-title":"PLoS One"},{"key":"key20180108132720_b27-etm-0-0-3640","first-page":"785","article-title":"Expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage","volume":"4","author":"Chu","year":"2011","journal-title":"Mol Med Rep"},{"key":"key20180108132720_b28-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1007\/s12975-012-0182-9","article-title":"Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage","volume":"3","author":"Strahle","year":"2012","journal-title":"Transl Stroke Res"},{"key":"key20180108132720_b29-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.pneurobio.2011.05.005","article-title":"Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: Facts and illusions","volume":"94","author":"Ore\u0161kovi\u0107","year":"2011","journal-title":"Prog Neurobiol"},{"key":"key20180108132720_b30-etm-0-0-3640","first-page":"1131","article-title":"Paracrine role for TGF-\u03b2-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular disease","volume":"27","author":"Lee","year":"2012","journal-title":"Histol Histopathol"},{"key":"key20180108132720_b31-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00004647-200102000-00007","article-title":"Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage: Titers derived from exogenous and endogenous sources","volume":"21","author":"Flood","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20180108132720_b32-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"38032","DOI":"10.1074\/jbc.M405658200","article-title":"Molecular interactions that confer latency to transforming growth factor-beta","volume":"279","author":"Young","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180108132720_b33-etm-0-0-3640","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/ATVBAHA.114.304732","article-title":"A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse","volume":"35","author":"Krishna","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3640\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T23:26:54Z","timestamp":1515454014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,31]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,31]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/etm.2016.3640"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3640","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,31]]}}}