{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:39:44Z","timestamp":1779302384151,"version":"3.51.4"},"reference-count":31,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.3892\/etm.2016.3720","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T03:46:30Z","timestamp":1474343190000},"page":"3121-3129","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of the efficacy of steroid therapy on acute liver failure"],"prefix":"10.3892","volume":"12","author":[{"given":"Bo","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Juan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ping","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"key20180108132859_b1-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2036.2012.05097.x","article-title":"Systematic review: Acute liver failure-one disease, more than 40 definitions","volume":"35","author":"Wlodzimirow","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180108132859_b2-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.20703","article-title":"AASLD position paper: The management of acute liver failure","volume":"41","author":"Polson","year":"2005","journal-title":"Hepatology"},{"key":"key20180108132859_b3-etm-0-0-3720","first-page":"321","article-title":"CSoID and Severe Liver and Disease and Artificial Liver Group, CSoH: Guideline for diagnosis and treatment of liver failure","volume":"5","year":"2012","journal-title":"Zhong Hua Lin Chuang Gan Ran Bing Za Zhi"},{"key":"key20180108132859_b4-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00535-005-1781-y","article-title":"Etiological investigation of fatal liver failure during the course of chronic hepatitis B in southeast China","volume":"41","author":"Ke","year":"2006","journal-title":"J Gastroenterol"},{"key":"key20180108132859_b5-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal","year":"2010","journal-title":"Lancet"},{"key":"key20180108132859_b6-etm-0-0-3720","first-page":"161","article-title":"Acute liver failure in adults: An evidence-based management protocol for clinicians","volume":"8","author":"Patton","year":"2012","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"key20180108132859_b7-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1478-3231.2010.02262.x","article-title":"Acute liver failure: Mechanisms of immune-mediated liver injury","volume":"30","author":"Wu","year":"2010","journal-title":"Liver Int"},{"key":"key20180108132859_b8-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"key":"key20180108132859_b9-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fphys.2015.00178","article-title":"Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure","volume":"6","author":"Weng","year":"2015","journal-title":"Front Physiol"},{"key":"key20180108132859_b10-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1478-3231.2007.01590.x","article-title":"Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine","volume":"27","author":"Higuchi","year":"2007","journal-title":"Liver Int"},{"key":"key20180108132859_b11-etm-0-0-3720","first-page":"376","article-title":"Methylprednisolone inhibits activated CD4+ T cell survival promoted by toll-like receptor ligands","volume":"9","author":"Lu","year":"2010","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"key20180108132859_b12-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/hep.1840080109","article-title":"Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity","volume":"8","author":"Dich","year":"1988","journal-title":"Hepatology"},{"key":"key20180108132859_b13-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/sj.cdd.4401771","article-title":"Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP","volume":"13","author":"Oh","year":"2006","journal-title":"Cell Death Differ"},{"key":"key20180108132859_b14-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11626-009-9261-y","article-title":"Dexamethasone protects cultured rat hepatocytes against cadmium toxicity: Involvement of cellular thiols","volume":"46","author":"Ferrigno","year":"2010","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"key20180108132859_b15-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1872-034X.2010.00740.x","article-title":"Efficacy of short-term dexamethasone therapy in acute-on-chronic pre-liver failure","volume":"41","author":"Zhang","year":"2011","journal-title":"Hepatol Res"},{"key":"key20180108132859_b16-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1743-422X-9-136","article-title":"Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid","volume":"9","author":"Mao","year":"2012","journal-title":"Virol J"},{"key":"key20180108132859_b17-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00535-008-2222-5","article-title":"Efficacy of combination therapy of antiviral and immunosuppressive drugs for the treatment of severe acute exacerbation of chronic hepatitis B","volume":"43","author":"Fujiwara","year":"2008","journal-title":"J Gastroenterol"},{"key":"key20180108132859_b18-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1620\/tjem.214.1","article-title":"Successful treatment of neonatal herpes simplex-type 1 infection complicated by hemophagocytic lymphohistiocytosis and acute liver failure","volume":"214","author":"Yamada","year":"2008","journal-title":"Tohoku J Exp Med"},{"key":"key20180108132859_b19-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/lt.21088","article-title":"Corticosteroids or not in severe acute or fulminant autoimmune hepatitis: Therapeutic brinksmanship and the point beyond salvation","volume":"13","author":"Czaja","year":"2007","journal-title":"Liver Transpl"},{"key":"key20180108132859_b20-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/hep.26678","article-title":"Steroid use in acute liver failure","volume":"59","author":"Karkhanis","year":"2014","journal-title":"Hepatology"},{"key":"key20180108132859_b21-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/hepr.12148","article-title":"Efficacy of high-dose corticosteroid in the early stage of viral acute liver failure","volume":"44","author":"Fujiwara","year":"2014","journal-title":"Hepatol Res"},{"key":"key20180108132859_b22-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1111\/j.1572-0241.2001.03964.x","article-title":"Hepatic Encephalopathy","volume":"96","author":"Blei","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"key20180108132859_b23-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.3748\/wjg.v19.i41.7069","article-title":"Advances in the management of acute liver failure","volume":"19","author":"Wang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"key20180108132859_b24-etm-0-0-3720","first-page":"141","article-title":"Living donor liver transplantation: where do we stand and where are we going?","volume":"5","author":"Lu","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"key20180108132859_b25-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1665-2681(19)30998-6","article-title":"The efficacy and safety of nucleos(t)ide analogues in the treatment of HBV-related acute-on-chronic liver failure: a meta-analysis","volume":"12","author":"Yu","year":"2013","journal-title":"Ann Hepatol"},{"key":"key20180108132859_b26-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hep.21486","article-title":"A randomized controlled trial of lamivudine to treat acute hepatitis B","volume":"45","author":"Kumar","year":"2007","journal-title":"Hepatology"},{"key":"key20180108132859_b27-etm-0-0-3720","first-page":"122","article-title":"Prognostic models for acute liver failure","volume":"9","author":"Du","year":"2010","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"key20180108132859_b28-etm-0-0-3720","first-page":"1516","article-title":"Overweight patients are more susceptible for acute liver failure","volume":"52","author":"Canbay","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"key20180108132859_b29-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/gut.14.10.805","article-title":"Acute hepatic necrosis and fulminant hepatic failure","volume":"14","author":"Rueff","year":"1973","journal-title":"Gut"},{"key":"key20180108132859_b30-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1440-1746.2009.05924.x","article-title":"Severe acute exacerbation of chronic hepatitis B: A unique presentation of a common disease","volume":"24","author":"Wong","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"key20180108132859_b31-etm-0-0-3720","doi-asserted-by":"crossref","first-page":"309","DOI":"10.7150\/ijms.5.309","article-title":"Lamivudine treatment for severe acute HBV hepatitis","volume":"5","author":"Lisotti","year":"2008","journal-title":"Int J Med Sci"}],"container-title":["Experimental and Therapeutic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/etm.2016.3720\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T15:48:42Z","timestamp":1568389722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2016.3720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,20]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,9,20]]},"published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.3892\/etm.2016.3720"],"URL":"https:\/\/doi.org\/10.3892\/etm.2016.3720","relation":{},"ISSN":["1792-0981","1792-1015"],"issn-type":[{"value":"1792-0981","type":"print"},{"value":"1792-1015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,20]]}}}